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Zusammenfassung

Die einheimische Sprue (Zöliakie des Kindesalters) oder glutensensitive Enteropathie ist gekennzeichnet durch eine Fehlverdauung und geht klinisch mit profusen voluminösen Diarrhöen einher. Sie ist eine genetisch und nahrungsmittelbedingte Enteropathie, bei der eine Intoleranz gegenüber Kornproteinen (Gliadine) zu einem lymphozytären Infiltrat des Dünndarmepithels, einem Umbau der Dünndarmschleimhaut und schließlich zu einem Malabsorptionssyndrom führt. Im Englischen werden Synonyma “gluten sensitive enteropathy, GSE, coeliac disease, non tropical sprue” verwandt.

Key words

Epidermiologie Genetik HLA-System Immunologie Gliadin-Derivate Gliadin-Bindung Gliadin-Antikörper Lektin-Wirkung Zytotoxizität extrazellulare Matrix Basalmembran Elektronenmikroskopie Eicanosoide Klinik Malignität glutenfreie Diät Compliance Remission 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Lorenz-Meyer
    • 1
  • U. Hahn
    • 2
  1. 1.Akademisches LehrkrankenhausFriedrichshafenDeutschland
  2. 2.Medizinische UniklinikErlangenDeutschland

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