Skip to main content
SpringerLink
Log in

Die einheimische Sprue

  • Conference paper
Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics

  • 15 Accesses

Zusammenfassung

Die einheimische Sprue (Zöliakie des Kindesalters) oder glutensensitive Enteropathie ist gekennzeichnet durch eine Fehlverdauung und geht klinisch mit profusen voluminösen Diarrhöen einher. Sie ist eine genetisch und nahrungsmittelbedingte Enteropathie, bei der eine Intoleranz gegenüber Kornproteinen (Gliadine) zu einem lymphozytären Infiltrat des Dünndarmepithels, einem Umbau der Dünndarmschleimhaut und schließlich zu einem Malabsorptionssyndrom führt. Im Englischen werden Synonyma “gluten sensitive enteropathy, GSE, coeliac disease, non tropical sprue” verwandt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Adelizzi RA, Pecora AA, Chiesa IC (1982) Coeliac disease: case report with an associated arthropathy. Am J Gastroenterol 77: 481–485

    PubMed  CAS  Google Scholar 

  • Adlersberg D, Wang CI, Bossak ET (1957) Disturbances in protein and lipid metabolism in malabsorption syndrome. J Mt Sinai Hosp (NY) 24: 206

    CAS  Google Scholar 

  • Allison AC (1974) The roles of lymphocytes in self tolerance and autoimmunity. Contemp Top Immunol 3: 227–242

    CAS  Google Scholar 

  • Anderson CM, Burke V (1975) Celiac disease. In: Anderson CM, Burke V (eds) Pediatric gastroenterology. Blackwell Scientific, Oxford, pp 175–197

    Google Scholar 

  • Anderson DH (1974) Celiac syndrome. J Pedatr 30: 564–582

    Article  Google Scholar 

  • Ashkenazi A, Idar D, Handzel ZT et al. (1978) An in vitro immunological assay for diagnosis of coeliac disease. Lancet 1: 627

    Article  PubMed  CAS  Google Scholar 

  • Ashkenazi A, Levin S, Idar D, Or A, Rosenberg I et al. (1980) Immunological assay for the diagnosis of coeliac disease: interaction between purified gluten fractions. Pediatr Res 14: 776–778

    Article  PubMed  CAS  Google Scholar 

  • Asquith P, Thompson RA, Cooke WT (1969) Serum immunoglobulins in adult coeliac disease. Lancet 11: 129

    Article  Google Scholar 

  • Auricchio S, de Ritis G, de Vincenci, Occorsio P, Silano V (1982) Effects of gliadin-derived peptides from bread and durum wheats on small intestine cultures from the rat fetus and coeliac children. Pediatr Res 16: 1004–1010

    Article  PubMed  CAS  Google Scholar 

  • Auricchio S, Cardelli M, de Ritis G et al. (1984) An in vitro animal model for the study of cereal components toxic in celiac disease. Pediatr Res 18: 1372–1378

    Article  PubMed  CAS  Google Scholar 

  • Baklien K, Brandtzaeg P, Fausa O (1977) Immunglobulins in jejunal mucosa and serum from patients with adult coeliac disease. Scand J Gastroenterol 12: 149–159

    Article  PubMed  CAS  Google Scholar 

  • Barclay N, Mason DW (1982) Induction of Ia antigen in rat epidermal cells and gut epithelium immunological stimuli. J Exp Med 156: 1665–1676

    Article  PubMed  CAS  Google Scholar 

  • Bayless TM, Kapelowitz RF, Shelley WM, Ballinger WF, Hendrix TR (1967) Intestinal ulceration — a complication of coeliac disease. N Engl J Med 276: 996–1002

    Article  PubMed  CAS  Google Scholar 

  • Beguinot L, Aurrichio S, Bernardin JE et al. (1986) In vitro activation of adenylate cyclase of atrophic celiac intestinal mucosa by wheat gliadin derived peptides. Pediatr Res 20: 42–44

    Article  PubMed  CAS  Google Scholar 

  • Berg NO, Dalqvist A, Lindberg T et al. (1970) Intestinal dipeptidases and disaccarides in celiac disease in adults. Gastroenterology 59: 575

    PubMed  CAS  Google Scholar 

  • Betuel H, Gebuhrer L, Percebois H et al. (1979) Association de la maladie coeliaque de l’adult avec HLA-DRW3 et DRW7. Gastroenterol Clin Biol 3: 605–606

    PubMed  CAS  Google Scholar 

  • Birrel WT, Eade OE, Fitzpatrik TF, Hyde I, McLeod NM, Wright R (1978) Bird fanciers lung and jejunal villous atrophy. Lancet 11: 1006–1008

    Google Scholar 

  • Bloch R, Menge H, Lingelbach B, Lorenz-Meyer H, Haberich FJ, Riecken EO (1973) The relationship between structure and function of small intestine in patients with a sprue syndrome and in healthy controls. Klin Wochenschr 51: 1151–1158

    Article  PubMed  CAS  Google Scholar 

  • Bloom SR, Polak JM (1982) Trophic influence in the gut. In: Bloom SR, Polak JM, Lindenlaub E (eds) Systemic role of regulatory peptides. Schattauer, Stuttgart New York, pp 211–227

    Google Scholar 

  • Bloom SR, Patel HR, Johnston DI (1976) Failure of secretin release in coeliac disease. Gut 17: 812

    Article  Google Scholar 

  • Booth CC, Stewart JS, Holmes R, Brackenbury W (1962) Dissecting microscope appearances of intestinal mucosa. In: Ciba Foundation Group 14 (eds) Intestinal biopsy. Churchill Livingstone, London, pp 2–23

    Google Scholar 

  • Bossak ET, Wang CI, Adlersberg D (1957) Clinical aspects of the malabsorption syndrome (idiopathik sprue). In: Adlersberg D (ed) The malabsorption syndrome. Grune and Stratton, New York, pp 112–129

    Google Scholar 

  • Bostad L, Schjolseth SA, Bjak P (1982) Malignant histiocytosis and adult coeliac disease. Scand J Haematol 28: 352–356

    Article  PubMed  CAS  Google Scholar 

  • Bourne JT, Kumar P, Huskisson EC, Mageed R, Unsworth DJ, Wojtulewski JA (1985) Artritis and coeliac disease. An Rheumatic Dis 44: 592–598

    Article  CAS  Google Scholar 

  • Bramble MG, Watson Ai, Scott J, Peters TJ, Record CO (1981) Clinical biochemical and morphological response of patients with villous atrophy to oral Bethametasone valerate and Clobatasone butyrat. Digestion 22: 281–288

    Article  PubMed  CAS  Google Scholar 

  • Bramble MG, Zucoloto S, Wright NA, Record CO (1985) Cute gluten challenge in treated adult coeliac disease: a morphometric and enzymatic study. Gut 26: 169–174

    Article  PubMed  CAS  Google Scholar 

  • Brautbar C, Zlotogore J, Laufer N, Cohen T, Albert ED (1984) Do identical dependent diabetes mellits. Tissue Antigens 23: 58–60

    Article  PubMed  CAS  Google Scholar 

  • Brown DL, Cooper AG, Hepper GW (1969) IgM metabolism in coeliac disease. Lancet I: 858–861

    Google Scholar 

  • Browning TH, Trier JS (1969) Organ culture of mucosa biopsies of human small intestine. J Clin Invest 48: 14–23

    Article  Google Scholar 

  • Bruce G, Woodley JF, Swan CHJ (1984) Breakdown of gliadin peptides by intestinal brushborders from coeliac patients. Gut 25: 919–924

    Article  PubMed  CAS  Google Scholar 

  • Bruce SE, Bjarnason I, Peters JT (1985) Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specifity with specials relation to gliadin and coeliac disease. Clin Sci 68: 573–579

    PubMed  CAS  Google Scholar 

  • Brunt PN, Sirens W, Maclean N (1969) Neoplasia and the coeliac syndrome in adults. Lancet 1: 180–184

    Article  PubMed  CAS  Google Scholar 

  • Burgin-Wolff A, Bertele RM, Berger R et al. (1983) A reliable screening test for childhood celiac disease: fluorescent immunabsorbent test for gliadin antibodies. J Pediatr: 655

    Google Scholar 

  • Bukhave K, Rask-Madsen J (1980) An approach to evaluation of local intestinal PG production and clinical assessment of it inhibition by indomethacin in chronic diarrhea. Adv Prostaglandin Thromboxan Res 8: 1627–1631

    CAS  Google Scholar 

  • Bullen AW, Losowski MS (1978) Lympocyte subpopulations in adult coeliac disease. Gut 19: 892–897

    Article  PubMed  CAS  Google Scholar 

  • Bullen AW, Ertan A, Brooks FT, Losowski MS (1977) Mechanism of thrombocytosis in coeliac disease. Gut 18: A962

    Google Scholar 

  • Bullen AW, Hall R, Gowland G, Raja S, Losowski MS (1980) Hyposplenism, adult coeliac disease, and autoimmunity. Gut 21: 28–33

    Article  Google Scholar 

  • Cacciari E, Salardi S, Volta U et al. (1985) Can antigliadin antibody detect symptomless coeliac disease in children with short stature? Lancet 1: 1469–1470

    Article  PubMed  CAS  Google Scholar 

  • Camilleri M, Krausz T, Lewis PD, Hodgson HJF, Pallis CA, Chadwik VS (1983) Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease. Gut 24: 441–447

    Article  PubMed  CAS  Google Scholar 

  • Campbell CB, Roberts RK, Cowen AE (1977) The changing clinical presentation of coeliac disease in adults. Med J Aust 1: 89–93

    PubMed  CAS  Google Scholar 

  • Carruthers L, Dourmashkin R, Alan P (1986) Disorders of the cytoskeleton of the enterocyte. Clin Gastroenterol 15: 105–120

    PubMed  CAS  Google Scholar 

  • Cerf-Bensussan N, Quaroni A, Kurnick JT, Bhan AK (1984) Intraepithelial lymphozytes modulate Ia expression by intestinal epithelial cells. J Immunol 132: 22–44

    Google Scholar 

  • Chapman BL, Henty H, Paice F, Coghill NF, Stewart JS (1974) Measuring the response of the jejunal mucosa in adult coeliac disease to treatment with a gluten free diet. Gut 15: 870

    Article  PubMed  CAS  Google Scholar 

  • Chapman RWG, Laidlo JM, Colin-Jones D, Eade 0E, Smith CL (1978) Increased prevalance of epilepsy in coeliac disease. Br Med J 2: 250–251

    Article  PubMed  CAS  Google Scholar 

  • Ciclitira PJ, Ellis HJ, Evans DJ (1983) A solid phase radioimmunoassay for measurement of circulating antibody titres of wheat gliadin and its subfractions in patients with adult coeliac disease. J Immunol Methods 62: 231–239

    Article  PubMed  CAS  Google Scholar 

  • Ciclitira Pi, Evans DJ, Lennox ES, Fagg NLK, Dowling RH (1984) Clinical testing of gliadin fractions in coeliac patients. Clin Sci 66: 357–364

    PubMed  CAS  Google Scholar 

  • Cluysenear OJJ, v. Tongeren JHM (1985) Coeliac disease presenting with intestinal pseudoobstruction. Gut 26: 538

    Article  Google Scholar 

  • Cobden I, Rothwell J, Axon ATR (1980) Intestinal permeability and screening test for coeliac disease. Gut 21: 512–518

    Article  PubMed  CAS  Google Scholar 

  • Collins BJ, Bell PM, McMaster D, Love AHG (1984) Selenium in coeliac disease. Br Med J 289: 439

    Article  CAS  Google Scholar 

  • Colyer J, Farthing MJG, Kumar PJ et al. (1986) Repraisal of the lectin hypothesis’ in the aetiopathogenesis of coeliac disease. Clin Sci 71: 105–110

    PubMed  CAS  Google Scholar 

  • Condong PJ, Fiddler GI, Littlewood JM, Scott O (1982) Coeliac disease in children with congenital heart disease. Arch Dis Child 57: 78–79

    Google Scholar 

  • Cooke WT, Holmes GKT (1984) Coeliac disease. Immunology. Churchill Livingstone, New York, pp 247–263

    Google Scholar 

  • Cooke WT, Smith WT (1963) Neurological disorders associated with adult coeliac disease. Brain 89: 683

    Article  Google Scholar 

  • Cooke WT, Peeney ALP, Hawkins CF (1953) Symptoms signs an diagnostic features of idiopathic steatorrhoea. Q J Med 22: 59–77

    PubMed  CAS  Google Scholar 

  • Cooper BT, Holmes GKT, Cooke WT (1978) Coeliac disease and immunological disorders. Br Med J I: 537–539

    Google Scholar 

  • Cooper BT, Holmes GKT, Cooke WT (1982) Lymphoma risk in coeliac disease of later life. Digestion 23: 89–92

    Article  PubMed  CAS  Google Scholar 

  • Corazza GR, Lazzari R, Frisoni M, Collina A, Gasbarrini G (1982) Splenic function in childhood coeliac disease. Gut 23: 415–416

    Article  PubMed  CAS  Google Scholar 

  • Corazza GR, Frisoni M, Vaira D, Gasbarrini G (1983) Effects of gluten free diet on splenic hypo-function of a adult coeliac disease. Gut 24: 228–230

    Article  PubMed  CAS  Google Scholar 

  • Corazza GR, Frazzoni M, Gasbarrini (1984) Jejunal intraepithelial lymphocytes in coeliac disease: are they increased or decreased. Gut 25: 158–162

    Article  PubMed  CAS  Google Scholar 

  • Cornell JH, Rolles CJ (1978) Further evidence of primary mucosal defect in coeliac disease. Gut 19: 253

    Article  PubMed  CAS  Google Scholar 

  • Crowe JP, Phelan JJ, Cleere WF et al. (1980) The lymphocyte transformation test in coeliac disease: effect of gliadin and detoxified gliadin. Digestion 20: 95–99

    Article  PubMed  CAS  Google Scholar 

  • Cudworth AG, Woodrow JC (1974) HLA-antigens and diabetes mellitus. Lancet 11: 1153

    Article  Google Scholar 

  • Cunningham-Rundles S, Cunningham-Rundles C, Pollack MS, Good RA, Dupont B (1978) Response to wheat antigen in vitro lympocyte transformation among HLA-B8-positive normal donors. Transplant Proc 10: 977–979

    PubMed  CAS  Google Scholar 

  • Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ (1984) The detailed distribution of MHC class II antigens in normal human organs. Transplantation 38: 293–298

    Article  PubMed  CAS  Google Scholar 

  • Daum F, Boley SJ, Cohen ML (1974) Miliary Crohn’s disease. Gastroenterology 67: 527–530

    PubMed  CAS  Google Scholar 

  • Davies MDJ, Parrot DMV (1981) Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine. Gut 22: 481–488

    Article  PubMed  CAS  Google Scholar 

  • Dawes DT, Atherton ST (1981) Coeliac disease presenting as recurrent pericarditis. Lancet I: 1021–1022

    Article  Google Scholar 

  • Dawson DJ, Sciberras CM, Whitwell H (1984) Coeliac disease presenting with intestinal pseudo-obstruction. Gut 25: 1003–1008

    Article  PubMed  CAS  Google Scholar 

  • Delamarre J, Capron JP, J my JP et al. (1984) Gallbladder inertic in celiac disease: ultrasonographic demonstration. Dig Dis Sci 29: 876

    Article  PubMed  CAS  Google Scholar 

  • Demarchi M, Carbonara A, Ansaldi N, Santin B, Barbera C, Borelli I, Rossino P, Rendine S (1983) HLA-DR3 and DR7 in coeliac disease: immunogenetic and clinical aspects. Gut 24: 706–712

    Article  PubMed  CAS  Google Scholar 

  • Dicke WK (1950) Coeliac disease. Investigation of the harmfull effects of certains types of cereal on patients with coeliac disease. Reichsuniversität Utrecht

    Google Scholar 

  • DiMagno EP, Go VLW, Summerskill WHJ (1972) Impaired cholecystokinin-pancreomycin secretion, intraluminal dilution, and maldigestion of fat in sprue. Gastroenterogy 63: 25–32

    CAS  Google Scholar 

  • Dobbins W (1986) Human intestinal intraepithelial lymphocytes. Gut 27: 972–985

    Article  PubMed  Google Scholar 

  • Dohan FC (1966) Cereals and schizophrenia data and hypothesis. Acta Psychiatr Scand 42: 125–152

    Article  PubMed  CAS  Google Scholar 

  • Dohan FC (1970) Coeliac disease and schizophrenia. Lancet 1: 897–899

    Article  PubMed  CAS  Google Scholar 

  • Doherti M, Barry RE (1981) Gluten induced mucosal changes in subjects without overt small bowell disease. Lancet 1: 517–520

    Article  Google Scholar 

  • Doe WF, Booth CC, Brown DL (1973) Evidence for complement binding immune complexes in adult coeliac disease, Crohns disease and ulcerative colitis. Lancet 1: 402–403

    Article  PubMed  CAS  Google Scholar 

  • Dombrowski H, Pemsel HK (1974) Angiographie bei entzündlichen Dünndarmerkrankungen and beim Mesenterialinfarkt. Radiologe 14: 415–424

    PubMed  CAS  Google Scholar 

  • Dombrowski H, Riecken EO (1970) Röntgenologische and lupenmikroskopische Befunde am oberen Dünndarm. Radiologe 10: 25–29

    PubMed  CAS  Google Scholar 

  • Dosetor JFB, Gibson AAM, McNeish AS (1981) Childhood coeliac disease is disappearing. Lancet 1: 322–325

    Article  Google Scholar 

  • Domschke S, Bloom SR, Domschke W, Demling L (1981) Glutenenteropathie and gastrointesti- nale Hormone; pathophysiologische and klinische Aspekte. Z Gastroenterol 19: 756–766

    PubMed  CAS  Google Scholar 

  • Domschke S, Bloom SR, Adria TE, Lux G, Bryant MG, Domschke W (1983) Anreicherung peptiderger Neurotransmitter in der Duodenalschleimhaut beim Ulcus duodeni-Leiden and bei Gluten-Enteropathie. Z Gastroenterol 21: 418–419

    Google Scholar 

  • Douglas AP (1976) The binding of a glucopeptide component of wheat gluten to intestinal mucosa of normal and coeliac human subjects. Clin Chim Acta 73: 357–361

    Article  PubMed  CAS  Google Scholar 

  • Douglas JG, Gillon J, Logan RFA, Frant IWB, Crompton GK (1984) Sarcoidosis and coeliac disease, an association? Lancet 2: 13–15

    Article  PubMed  CAS  Google Scholar 

  • Dunger D, Leonhard JV, Wolff OH, Pearce MA (1980) Effect of naloxone in a previously undescribed hypothalamic syndrome. A disorder of endogenous opioid peptide system? Lancet 1277–1281

    Google Scholar 

  • Ecker J, Williams R, Clay K (1971) Pneumatosis cystoides intestinalis — bullous emphysema of the intestine. Am J Gastroenterol 56: 125–136

    PubMed  CAS  Google Scholar 

  • Edwards C, Williams A, Asquith P (1985) Bronchiopulmonary disease in coeliac patients. J Pathol 38: 361–367

    CAS  Google Scholar 

  • Eliakim R, Heyman S, Kornberg A (1982) Celiac disease and keratoconjunctivitis. Arch Intern Med 142: 1037

    Article  PubMed  CAS  Google Scholar 

  • Elias E, Mackinnon AM, Short MO, Dowling RH (1973) Factors controlling ileas adaptation after proximal small bowel resection and in coeliac disease. Eur J Clin Invest 9: 226

    Google Scholar 

  • Ellis A, Tailor CJ, Dillon-Remmy M, Woodrow JC, McConnell RB (1984) HLA-DR typing in coeliac disease; evidence for genetic heterogeneity. Br Med J 289: 1575–1573

    Google Scholar 

  • Ellis JC, Dockray GJ (1982) Identification and measurements of molecular variants of cholecystokinin in duodenal mucosa and plasma. Br Med J 289: 1571–1573

    Article  Google Scholar 

  • Elmes M, Goldan MK, Love AHS (1976) Unresponsive coeliac disease. Q J Med 69: 696–697

    Google Scholar 

  • Faizallah R, Costello FC, Lee FI, Walker R (1982) Adult celiac disease and recurrent pericarditis. Dig Dis Sci 27: 728–730

    Article  PubMed  CAS  Google Scholar 

  • Falchuk ZM (1983) Gluten sensitive enteropathy. Clin Gastroenterol 12: 475–494

    PubMed  CAS  Google Scholar 

  • Falchuk ZM, Strober W (1974) Gluten-sensitive enteropathy: synthesis of antigliadin antibody in vitro. Gut 15: 947–952

    Article  PubMed  CAS  Google Scholar 

  • Falchuk ZM, Rogentine NG, Strober W (1972) Predominance of histocompatibility antigen HL-8 and patients with gluten-sensitive enteropathy. J Clin Invest 51: 1602–1605

    Article  PubMed  CAS  Google Scholar 

  • Falchuk ZM, Gebhard RL, Sessoms C, Strober W (1974) An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture. J Clin Invest 53: 487–500

    Article  PubMed  CAS  Google Scholar 

  • Falchuk ZM, Nelson DL, Katz AJ et al. (1980) Glutensensitive enteropathy: influence of histocompatibility type on gluten sensitivity in vitro. J Clin Invest 66: 227–233

    Article  PubMed  CAS  Google Scholar 

  • Farthing MJG, Rees LH, Edwards CRW, Byfield PGH, Him sworth RL, Dawson AM (1982a) Thyreoid hormones and the regulation of the thyroid function in men with coeliac disease. Clin Endocrinol 16: 525–535

    Article  CAS  Google Scholar 

  • Farthing MJG, Edwards CRW, Rees LH, Dawson AM (1982b) Male gonadal function in celiac disease: 1. sexual dysfunction, infertility, and semen quality. Gut 23: 608–614

    Article  PubMed  CAS  Google Scholar 

  • Farthing MJG, Rees LH, Edwards CRW, Dawson AM (1983a) Male gonadal function in celiac disease: 2. sex hormones. Gut 24: 127–135

    Article  PubMed  CAS  Google Scholar 

  • Farthing MJG, Rees LH, Dawson AM (1983b) Male gonadal function in coeliac disease: 3. pituitary function. Clin Endocrinol 19: 661–671

    Article  CAS  Google Scholar 

  • Ferguson A (1977) Intraepithelial lymphocytes of the small intestine. Gut 18: 921–937

    Article  PubMed  CAS  Google Scholar 

  • Ferguson A, Ziegler K (1986) Intraepithelial lymphocyte mitosis in an jejunal biopsy correlates with intraepithelial lymphocyte count, irrespective of diagnosis. 27: 675–679

    CAS  Google Scholar 

  • Ferguson A, Ziegler K, Strobel S (1984) Glutenintolerance ( Coeliac disease ). Ann Allerg 53: 637–642

    PubMed  CAS  Google Scholar 

  • Ferguson R, Holmes GKT, Cooke WT (1982) Coeliac disease, fertility, and pregnancy. Scand J Gastroenterol 1: 65–68

    Article  Google Scholar 

  • Finelli PF, McEntee WJ, Ambler M, Kestenbaum D (1980) Adult coeliac disease presenting as cerebellar syndrome. Neurology 30: 245–249

    PubMed  CAS  Google Scholar 

  • Fluge G, Aksnes L (1981) Morphological and morphometric assessment of human duodenal biopsies maintained in organ culture. Scand J Gastroenterol 16: 555–567

    Article  PubMed  CAS  Google Scholar 

  • Fluge G, Andersen K-J, Aksnes L, Thunold K (1982) Brush border and lysosomal marker enzyme profiles and duodenal mucosa from coeliac patients before and after organ culture. Scand J Gastroenterol 17: 465–472

    Article  PubMed  CAS  Google Scholar 

  • Fordtran JS, Rector FC, Locklear TW, Ewton MF (1967) Water and solute movement in the small intestine of patients with sprue. J Clin Invest 46: 287–298

    Article  PubMed  CAS  Google Scholar 

  • Frank PH, O’Connell DJ (1977) Pneumatosìs cystoides intestinales and obstructing intussucception in coeliac disease. Gastrointest Radiol 2: 109–111

    Article  PubMed  CAS  Google Scholar 

  • Frazer AC (1956) Discussion on some problems of steatorrhoea and reduced stature on the growth defect in coeliac disease. Proc R Soc Med 49: 1009–1013

    PubMed  CAS  Google Scholar 

  • Frazer AC (1968) Malabsorption syndromes. William Heinemann Medical, London

    Google Scholar 

  • Frazer AC, Fletcher RF, Ross CAC et al. (1959) Gluten induced enteropathy. The effect of partially digested gliadin. Lancet 2: 252–255

    Article  PubMed  CAS  Google Scholar 

  • Freeman HJ, Weinstein WM, Shnitka TK, Pircey IRA, Wensel RH (1977) Primary abdominal lymphoma presenting manifestation of coeliac sprue complicating dermatitis herpetiformis. Am J Med 63: 585–594

    Article  PubMed  CAS  Google Scholar 

  • Gee S (1888) On the coeliac affection. St Bart Hosp Rep 24: 17–20

    Google Scholar 

  • Gefter WB, Evers KA, Malet PF, Kressel HY, Thompson JJ (1981) Nontropical sprue with pneumatosis coli. Am J Radiol 137: 624–625

    CAS  Google Scholar 

  • Gillberg R, Dotewall R, Ahren C (1982) Chronic inflammatory bowel disease in patients with coeliac disease. Scand J Gastroenterol 17: 491–496

    Article  PubMed  CAS  Google Scholar 

  • Glasgow JFT, Pinkerton CR, Sloam JM (1983) Serosal miliary Crohn’s disease in association with probable coeliac disease. Arch Child Dis 58:140–151

    Google Scholar 

  • Glover SC, Brunt PW, Mills CF, Mowat N (1976) Zinc absorption and adult coeliac disease. Gut 17: 813

    Google Scholar 

  • Goetzl J (1981) Selective feedback inhibition of the 5-lipoxigenation pathway of arachidonic acid in human T-lymphocytes. Biochem Biophys Res Comm 101: 344

    Article  PubMed  CAS  Google Scholar 

  • Goodwin J, Ceuppens J (1983) Regulation of the immune response by prostaglandins. J Clin Immunol 3: 295–315

    Article  PubMed  CAS  Google Scholar 

  • Griboski (1981) False security of a gluten-free diet. Am J Dis Child 135: 110–111

    Google Scholar 

  • Green PA, Wollaeger EE (1960) The clinical behaviour of sprue in the United States. Gastroenterology 38: 399–418

    PubMed  CAS  Google Scholar 

  • Greenwood JH, Austin LL, Dobbins WO (1983) In vitro characterization of human intestinal intraepithelial lymphocytes. Gastroenterology 85: 1023–1035

    PubMed  CAS  Google Scholar 

  • Gregory G, Ashworth M, Eade 0E, Holdstock G, Smith CL, Wright R (1983) Delay in diagnosis of adult coeliac disease. Digestion 28: 201–204

    CAS  Google Scholar 

  • Gualde N, Atluru D, Goodwin JS (1985) Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T-cells and T-cell subsets. J Immunol 134: 1125–1129

    PubMed  CAS  Google Scholar 

  • Gustafson T, Sjölund K, Berg N-O (1982) Intestinal circulation in coeliac disease: an angiographic study. Scand J Gastroenterol 17: 881–885.

    Article  PubMed  CAS  Google Scholar 

  • Guy-Grand D, Griscelli C, Vassalli P (1978) The mouse gut T-lymphocyte, a novel cell type of T-cell. J Exp Med 148: 1661–1667

    Article  PubMed  CAS  Google Scholar 

  • Haas SV (1932) Coeliac disease, its specific treatment and cure without nutritional relapse. JAMA 99: 448

    Google Scholar 

  • Haeney MR, Asquith P (1978) In vitro immunological assay for diagnosis of coeliac disease. Lancet 1: 876

    Article  PubMed  CAS  Google Scholar 

  • Haffen K, Kedinger M, Lacroix B (1976) Cytodifferentiation of the intestinal villus epithelium. In: Desnuelle, Sjöström, Noren (eds) Molecular and cellular basis of digestion. Elsevier Science, New York, pp 311–322

    Google Scholar 

  • Hagander B, Brandt L, Sjölund K, Berg NO, Norden A, Stensham M (1977) Hepatic injury in adult coeliac disease. Lancet 11: 270–272

    Article  Google Scholar 

  • Hahn U, Schuppau D, Hahn EG, Riecken EO (1985) Immunhistologische Charakterisierung interstitieller antigener Substanzen in der Darmwand. Fortschr Gastroenterol Endoskop 14: 198–200

    Google Scholar 

  • Hahn U, Schuppan D, Hahn EG, Merker HJ, Riecken EO (1987a) Cell matrix in the differentiation of the intestinal epithelium. In: Olff JR, Sievers J, Berry M (eds) Mesenchymal-epithelial interactions in neural development. (NATO ASI Series, vol H5 )

    Google Scholar 

  • Hahn U, Schuppan D, Hahn EG, Merker HJ, Riecken EO (1987b) Intestinal cells produce basement membran proteins in vitro. Gut 2851: 143–151

    Article  Google Scholar 

  • Hahn U, Stallmach, Hahn EG (1988) Submitted

    Google Scholar 

  • Hallert C, Astrom J (1982) Psychic disturbances in adult coeliac disease II. Psychological findings. Scand J Gastroenterol 17: 21–24

    Article  PubMed  CAS  Google Scholar 

  • Hallert C, Derefeldt T (1982) Psychic disturbances in adult coeliac disease. I Clinical observations. Scand J Gastroenterol 17: 17–19

    Article  PubMed  CAS  Google Scholar 

  • Hallert C, Norby K (1983) Malignant carcinoid tumour complicating coeliac disease. Acta Med Scand 213: 313–316

    Article  PubMed  CAS  Google Scholar 

  • Hallert C, Gotthard R, Norby K, Walan A (1981a) On the prevalence of adult coeliac disease in Sweden. Scand J Gastroenterol 16: 257–261

    Article  PubMed  CAS  Google Scholar 

  • Hallert C, Tobiasson P, Walan A (1981b) Serum folate determinations in tracing adult coeliacs. Scand J Gastroenterol 16: 263–267

    Article  PubMed  CAS  Google Scholar 

  • Hallert C, Astrom J, Sedvall O (1982a) Psychic disturbances in adult coeliac disease. III Reduced central monoamine metabolism and signs of depression. Scand J Gastroenterol 17: 25–28

    Article  PubMed  CAS  Google Scholar 

  • Hallert C, Martenson J, Allgen L-G (1982b) Brain availability of monoamine precursor in adult coeliac disease. J Gastroenterol 17: 87–89

    CAS  Google Scholar 

  • Hallert C, Gotthard R, Jansson G, Norby K, Wala A (1983) Similar prevalence of coeliac disease in children and middle-aged adults in a district of Sweden. Gut 24: 389–391

    Article  PubMed  CAS  Google Scholar 

  • Hamilton I, Cobden I, Rothwell J, Axon ATR (1982) Intestinal permeability in coeliac disease; the response to gluten withdrawal and a single-dose gluten challenge. Gut 23: 202–210

    Article  PubMed  CAS  Google Scholar 

  • Hand PH, Thor A, Schlom J, Rao CN, Liotta L (1985) Expression of laminin receptor in normal and carcinomatous human tissues as defined by a monoclonal antibody. Cancer Red 45: 2713–2717

    CAS  Google Scholar 

  • Hanly JG, Stassen W, Whelton M, Callaghan N (1982) Epilepsy and coeliac disease. J Neurol Neurosurg Psychiatr 45: 729–735

    Article  PubMed  CAS  Google Scholar 

  • Harris OD, Cooke WT, Thompson H, Waterhouse JAH (1967) Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med 42: 899–912

    Article  PubMed  CAS  Google Scholar 

  • Hauri HA, Hedinger M, Hoffen K, Gaze H, Hadorn B, Heckkens W (1978) Reevaluation of the technique of organ culture for studying gluten toxicity in coeliac disease. Gut 19: 1090–1098

    Article  PubMed  CAS  Google Scholar 

  • Hawkey CJ, Rampton DS (1985) Prostaglandins and the gastrointestinal mucosa: are they important in its function, disease or treatment? Gastroenterology 89: 1162–1188

    PubMed  CAS  Google Scholar 

  • Heaton KW, McCarthy CF, Horton RE, Cornes JS, Read AE (1967) Miliary Crohn’s disease. Gut 8: 4–7

    Article  PubMed  CAS  Google Scholar 

  • Heck J (1984) Malignes Lymphom des Dünndarms nach langjähriger Sprue. Dtsch Med Wochenschr 109: 1988

    Google Scholar 

  • Hedberg CA, Melynk CS, Johnson CF (1966) Gluten enteropathy appearing after gastric surgery. Gastroenterology 50: 796

    PubMed  CAS  Google Scholar 

  • Henriksson KG, Hallert C, Norby K, Walan A (1982) Polymysitis and adult coeliac disease. Acta Neurol Scand 65: 301–319

    Article  PubMed  CAS  Google Scholar 

  • Herter CA (1908) On infantilism from chronic intestinal infection. McMillan, New York

    Google Scholar 

  • Hess-Thaysen TE (1932) Non-tropical sprue. Humprey Milford Oxford University Press, London

    Google Scholar 

  • Heubner CA (1909) Über schwere Verdauungsinsuffizienz beim Kinde jenseits des Säuglingsalters. Jahrb Kinderheilkd 70: 767–700

    Google Scholar 

  • Hinks LJ, Inwards KD, Lloyd B, Clayton BE (1984) Body content of selenium in coeliac disease. Br Med J 288: 1862–1863

    Article  CAS  Google Scholar 

  • Hirata I, Linda LA, Blackwell H et al. (1986) Immunoelectron microscopic localization of HLADR antigen in control small intestine and colon and in inflammatory bowel disease. Dig Dis Sci 31: 1317–1330

    Article  PubMed  CAS  Google Scholar 

  • Hobbs JR, Hepper G (1968) Deficiency of gamma-M-globuline in coeliac disease. Lancet I: 217–220

    Google Scholar 

  • Hodges JR, Isaacson P, Smith CL, Sworn MC (1979) Malignant histiocytosis of the intestine. Dig Dis Sci 24: 631–638

    Article  PubMed  CAS  Google Scholar 

  • Holdstock G, Eade 0E, Jsaacson P, Smith CL (1979) Endoscopic duodenal biopsie in coeliac disease and duodenitis. Scand J Gastroenterol 14: 717–720

    Article  PubMed  CAS  Google Scholar 

  • Holmes GKT, Stokes PL, Sorahan TM et al. (1976) Coeliac disease, glutenfree diet and malignancy. Gut 17: 612–619

    Article  PubMed  CAS  Google Scholar 

  • Holoday JW, Loh HH, Hao LC (1978) Unique behavioral effects of endorphin and the relationship to thermoregulation and hypothalamic function. Life Sci 22: 1525–1536

    Article  Google Scholar 

  • Holst JJ, Sorensen A, Andersen AN et al. (1979) Plasma enteroglucagon after jejunal by-pass with 3:1 or 1:3 jejunoileal ratio. Scand J Gastroenterol 14: 205–207

    Article  PubMed  CAS  Google Scholar 

  • Horvath K, Graf L, Walcz E, Bodansky H, Schuler D (1985) Naloxone antagonizes effect of o-gliadine on leucocyte migration in patients with coeliac disease. Lancet II: 184–186

    Google Scholar 

  • Howdle PD, Corazza GR, Bullen AW, Losowsky MS (1981) In citro diagnosis of coeliac disease: an assessment. Gut 22: 939–947

    Article  PubMed  CAS  Google Scholar 

  • Howdle PD, Bullen AW, Losowsky MS (1982) Cell-mediated immunity to gluten within the small intestinal mucosa in coeliac disease. Gut 23: 115–122

    Article  PubMed  CAS  Google Scholar 

  • Howdle PD, Ciclitira PJ, Simpson FG, Losowsky MS (1984) Are allgliadins toxic in coeliac disease? Scand J Gastroenterol 9: 41–47

    Google Scholar 

  • Howdle PD, Wood GM, Losowsky MS (1986) Organ culture of fetal rat small intestine for testing gluten toxicity: a repraisal. Gut 27:Al244

    Google Scholar 

  • Howell MD, Austin RK, Kelleher D, Nepom GT, Kagnoff MF (1986) An HLA-D region restriction fragment length polimorphism associates with celiac disease. J Exp Med 164: 333–338

    Article  PubMed  CAS  Google Scholar 

  • Howell MD, Smith JR, Austin RK, Kelleher D, Nepom GT, Volk B, Kagnoff MF (1988) An extended HLA-D region haplotype associated with celiac disease. Proc Natl Acad Sci 85: 222–226

    Article  PubMed  CAS  Google Scholar 

  • Isaacson P (1983) Coeliac disease and malignancy. Lancet 1: 938

    Article  PubMed  CAS  Google Scholar 

  • Isaacson P, Wright DH (1980) Malabsorption and intestinal lymphomas. In: Wright R (ed) Recent advantages in gastrointestinal pathology. Saunders, London, pp 193–212

    Google Scholar 

  • Isaacson P, Wright DH, Judd MA, Mephan BL (1979) Primary gastrointestinal lymphomas. A classification of 66 cases. Cancer 43: 1805–1819

    Article  PubMed  CAS  Google Scholar 

  • James SP, Fiocchi C, Graeff AS, Strober W (1985) Immunregulatory functions of lamina propria T cells in Crohn’s disease. Gastroenterology 88: 1143–1150

    PubMed  CAS  Google Scholar 

  • Janossy G, Tidman N, Selby WS, Thomas JA, Granger S (1980) Human T lymphocytes of inducer and suppressor type occupy different microenvironments. Nature 288: 81–84

    Article  PubMed  CAS  Google Scholar 

  • Jarnum S, Jensen KB, Söltöft J, Westergaard H (1980) Protein loss and turnover of albumin, IgG and IgM in adult coeliac disease. In: Booth CC, Dowling RH (eds) Coeliac disease. Churchill Livingstone, Edinburgh, pp 163–172

    Google Scholar 

  • Jeffries GH (1978) Protein metabolism and protein-loosing enteropathy. In: Sleisinger MH, Fordtran IS (eds) Gastrointestinal disease. Saunders, Philadelphia, pp 1029–1051

    Google Scholar 

  • Jenkins D, Goodall A, Scott BB (1986) T-lymphocyte populations in normal and coeliac small intestinal mucosa defined by monoclonal antibodies. Gut 27: 1330–1337

    Article  PubMed  CAS  Google Scholar 

  • Johanson C, Uribe A, Rubio C, Isenberg JI (1986) Effect of oral prostaglandin EZ on DNA turnover in gastric and intestinal epithelia of the rat. Eur J Clin Invest 16: 509–514

    Article  Google Scholar 

  • Johnson HG, McNee ML, Sun FS (1985) 15-HETE is a potent inflammatory mediator and agonist of canine tracheal mucus secretion. Am Rev Respir Dis 131: 917–921

    PubMed  CAS  Google Scholar 

  • Jones B, Bayless TM, Fishman EK, Siegelman SS (1984) Lymphadenopathy in coeliac disease: computed tomographic observations. AJR 142: 1127–1132

    PubMed  CAS  Google Scholar 

  • Jones JG, Ehnes ME (1982) The measurement of mucosal non-myelinated nerve fibre area and endocrine cell area in coeliac disease using morphometric analysis. Diagn Histopathol 5: 183–188

    PubMed  CAS  Google Scholar 

  • Jones PE, Peters TJ (1981) Oral zinc supplements in non responsive coeliac syndrome: effect on jejunal morphology, enterocyte production and brushborder disaccharidase activities. Gut 22: 194–198

    Article  PubMed  CAS  Google Scholar 

  • Jos J, Charbonnier L, Mosse J et al. (1982) The toxic fraction of gliadin digest in coeliac ‘disease. Isolation by chromatography on Biogel P-10. Clin Chem Acta 119: 263–274

    Article  CAS  Google Scholar 

  • Jos J, de Tand MF, Arnoud-Battandier F, Boissel JP et al. (1983) Separation of pure toxic peptide from beta gliadin subfraction using high performance liquid chromatography. Clin Chim Acta 134: 189–198

    Article  PubMed  CAS  Google Scholar 

  • Kagnoff MF (1982) Two genetic loci control the murine immune response to A-glìadine, a wheat protein that activates coeliac sprue. Nature 296: 158–160

    Article  PubMed  CAS  Google Scholar 

  • Kagnoff MF (1987) Immunology of the digestive system. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven Press, New York

    Google Scholar 

  • Kagnoff MF, Austin RK, Hubert JJ, Bernardin JE, Kasarda DD (1984) Possible role for a human adenovirus in the pathogenesis of celiac disease. J Exp Med 160: 1544–1557

    Article  PubMed  CAS  Google Scholar 

  • Kagnoff MF, Paterson YJ, Kumar PJ, Kasarda DD, Carbone FR, Unsworth DJ, Austin RK (1987) Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease. Gut 28: 995–1001

    Article  PubMed  CAS  Google Scholar 

  • Kasarda DD (1980) Structure and properties of alpha gliadin. Am Technol Agric 29: 151–158

    CAS  Google Scholar 

  • Kasarda DD, Okita TW, Bernadin JE, Baecker PA, Nimmo CC, Lew EJL, Dietler MD, Greene FC (1984) Nucleic acid (cDNA) and amino acid sequence of alpha-type gliadins from wheat (triticum aestrivum). Proc Natl Acad Sci 81: 4712–4716

    Article  PubMed  CAS  Google Scholar 

  • Katz AJ, Falchuk ZM (1978) Definitive diagnosis of gluten-sensitive enteropathy. Use of an in vitro organ culture model. Gastroenterology 75: 695–700

    PubMed  CAS  Google Scholar 

  • Keunig JJ, Pena AS, van Leuwen A, van Hooff JP, van Rood JJ (1976) HLA-DW3 ‘associated with coeliac disease. Lancet 2: 506–507

    Article  Google Scholar 

  • Khuffash FA, Barakat MH, Majeed HA, White AG, Beseda AJ (1984) Coeliac disease in monocygotic twin girls. Synchronous presentation. Gut 25: 1009–1012

    Article  PubMed  CAS  Google Scholar 

  • Kieffer M, Frazier Pi, Daniels NWR, Coombs RRA (1982) Wheat gliadin fractions and other cereal antigens reactive with antibodies in the sera of coeliac patients. Clin Exp Immunol 50: 651–660

    PubMed  CAS  Google Scholar 

  • Kilander AF, Hanssen LE, Gillberg RE (1983) Secretin release in coeliac disease. Scand J Gastroenterol 18: 765–769

    Article  PubMed  CAS  Google Scholar 

  • Kilander AF, Dotewall G, Linstedt G, Lundberg PA (1984) Plasma enteroglucagon related to malabsorption in coeliac disease. Gut 25: 629–635

    Article  PubMed  CAS  Google Scholar 

  • Kinney HC, Burger PC, Hurwitz BJ, Hijman JC, Granz JP (1982) Degeneration of the central nervous system associated with coeliac disease. J Neurol Sci 53: 9–22

    Article  PubMed  CAS  Google Scholar 

  • Kitis G, Holmes GKT, Cooper BT, Thompson H, Alan RN (1980) Association of coeliac disease and inflammatory bowel disease. Gut 21: 636–641

    Article  PubMed  CAS  Google Scholar 

  • Krills SA, Macpherson JL, de Carle DJ, Daggard GE, Talley NA, Chesterman CN (1986) Small bowel mucosa from coeliac patients generates 15 hydroxyeicosatetraenoic acid (15-HETE) after in vitro challenge with gluten. J Immunol 137: 3768–3771

    Google Scholar 

  • Klemm G, Dannenberg C (1984) Erwachsenen Zöliakie mit sekundärem Hyperparathyreoidismus. Z Gesamt Inn Med 39: 488–489

    CAS  Google Scholar 

  • Kluge F, Koch HK, Grosse-Wilde H, Lesch R, Geraok W (1982) Follow up of treated adult coeliac disease. Clinical and morphological studies. Hepatogastroenterol 29: 17–23

    CAS  Google Scholar 

  • Kluge F, Koch HK, Köttgen E, Gerok W (1983) Glutensensitive Enteropathie im Lichte neuer klinischer and pathogenetischer Aspekte. Klin Wochenschr 61: 669–679

    Article  PubMed  CAS  Google Scholar 

  • Kluge G, Hoppe-Seyler P, Gerok W (1984) Immungenetische Befunde bei Morbus Crohn, Colitis ulcerosa and glutensensitiver Enteropathie. Z Gastroenterol 22: 277–284

    PubMed  CAS  Google Scholar 

  • Köttgen E (1986) Neue Aspekte zur glutensensitiven Enteropathie. Internist 27: 656–664

    PubMed  Google Scholar 

  • Köttgen E, Volk B, Kluge F, Gerok W (1982) Gluten, a lectin with ologomannosyl specificity and the causative agent of gluten-sensitive enteropathy. Biochem Biophys Res Corn 109: 168–173

    Article  Google Scholar 

  • Köttgen E, Kluge F, Volk B, Gerok W (1983) The lectin properties of gluten as the basis of the pathomechanism of gluten-sensitive enteropathy. Klin Wochenschr 61: 111–112

    Article  PubMed  Google Scholar 

  • König G, Albert E, Dewair M, Harms K, Bertele RM, Scholz S, Fruhmann G (1982) Extrinsic allergic alveolitis combined with coeliac disease in childhood. Respiration 43: 444–451

    Article  PubMed  Google Scholar 

  • Kolberg J, Solid (1985) Lectin activity of gluten identified as wheat germ agglutinin. Biochem Biophys Commun 130: 867–872

    Article  Google Scholar 

  • Komuro T (1985) Fenestrations of the basal lamina of the intestinal villi of the rat. Cell Tissue Res 239: 183–188

    Article  PubMed  CAS  Google Scholar 

  • Kragballe K, Desjarlais L, Duell EA, Vorhees JJ (1986) In vitro synthesis of 12-eicoser tetranoic acid is increased in univolved psoriatic epidermis. J Invest Dermatol 87: 47–52

    Article  PubMed  CAS  Google Scholar 

  • Kreis GJ (1983) Dünndarm als Sekretionsorgan: Wasser and Elektrolyt-Transport. In: Caspary W (Hrsg) Dünndarm Teil A. Springer, Berlin Heidelberg New York, S. 434–463 (Handbuch der inneren Medizin, Bd. 3/3A)

    Google Scholar 

  • Kumar RI (1985) The enigma of celiac disease. Gastroenterology 89: 214–216

    PubMed  CAS  Google Scholar 

  • Kumar PJ, Ferguson A, Lancaster-Smith M, Clark ML (1970) Food antibodies in patients with dermatitis herpetiformis and adult coeliac disease — a relationship to jejunal morphology. Scand J Gastroenterol 11: 5–9

    Google Scholar 

  • Kumar PJ, Oliver RTD, O’Donoghue DP, Ngahfoong L, Pallai A (1978) Relationship of HLA status to the clinical findings and autoimmunity in coeliac disease. Gut 19: A438

    Google Scholar 

  • Kumar P, O’Donoghue DP, Lancaster-Smith M (1979a) Cellular changes in the jenunal mucosa following reintroduction of gluten in treated coeliac disease. In: Pepy J, Edwards AM (eds) The mast cell. Pittman, Tunbridge Wells, pp 647–650

    Google Scholar 

  • Kumar PJ, O’Donoghue DP, Stenson K, Dawson AM (1979b) Reintroduction of gluten in adults and children with treated coeliac disease. Gut 20: 743–749

    Article  PubMed  CAS  Google Scholar 

  • Kumar PJ, Oliver RTD, O’Donoghue DP et al. (1981) The relationship of HLA-A;B status to the clinical findings and autoimmunity in coeliac disease. In: McConnell RD (ed) The genetics of coeliac disease. MTP, Lancaster, pp 173–185

    Google Scholar 

  • Kumar PJ, Sinclair TS, Farthing MJG et al. (1984) Clinical toxicity testing of pure gliadins in coeliac disease (abstr). Gastroenterology 86: 1147

    Google Scholar 

  • Laine WA, Holt KM (1984) Recurrent pericarditis and coeliac disease. JAMA 252: 3169

    Article  Google Scholar 

  • Lancaster-Smith MJ, Benson MK, Strickland ID (1971) Coeliac disease and diffuse intestinal lung disease. Lancet 1: 473–476

    Article  Google Scholar 

  • Lancaster-Smith MJ, Swarbrik ET, Perrin J, Wright JT (1974a) Coeliac disease and autoimmunity. Postgrad Med J 50: 45–48

    Article  PubMed  CAS  Google Scholar 

  • Lancaster-Smith M, Kumar PJ, Marks R, Clark ML, Dawson AM (1974b) Jejunal mucosal immun-globulin containing cell and jejunal fluid immunglobulins in adult coeliac disease and dermatitis herpetiformis. Gut 15: 371–376

    Article  PubMed  CAS  Google Scholar 

  • Lancaster-Smith M, Joyce S, Kumar P (1977) Immunglobulins in the jejunal mucosa in adult coeliac disease and dermatitis herpetiformis after the reintroduction of dietary gluten. Gut 18: 887–891

    Article  PubMed  CAS  Google Scholar 

  • Lance P, Gazzard BG (1983) Ulcerative enteritis and liver disease in a patient with coeliac disease. Gut 24: 433–437

    Article  PubMed  CAS  Google Scholar 

  • Langer W, Langer R (1984) Skelettveränderungen im Rahmen eines gastrointestinalen Malabsorptionssyndroms. Röntgenblätter 37: 226–227

    PubMed  CAS  Google Scholar 

  • Langman MJS, McConnell TH, Spiegelhalter DJ, McConnell RB (1985) Changing patterns of coeliac disease frequency: an analysis of coeliac society membership records. Gut 26: 175–178

    Article  PubMed  CAS  Google Scholar 

  • Laurie GW, Leblond CP, Martin GR (1982) Localisation of type IV collagen, laminin, heparan sulfate proteoglucan and fibronectin to the basal lamina of basement membranes. J Cell Biol 95: 340–344

    Article  PubMed  CAS  Google Scholar 

  • Lee FD (1966) Nature of mucosal changes associated with malignant neoplasm in the small intestine. Gut 7: 361–367

    Article  PubMed  CAS  Google Scholar 

  • Lebenthal E, Branski D (1981) Childhood coeliac disease — a reappraisal. J Pediat 98: 681–69

    Article  PubMed  CAS  Google Scholar 

  • Leigh RJ, Marsh MM, Crowe P, Kelly C, Garner V, Gordon D (1985) Studies of intestinal lymphoid tissue. IX. Dose-dependent, gluten-induced lymphoid infiltration of coeliac jejunal epithelium. Scand J Gastroenterol 20: 715–719

    Article  PubMed  CAS  Google Scholar 

  • Lembcke B, Caspary W (1983) Atemanalytische Funktionstests. In: Caspary W (Hrsg) Dünndarm, Teil A. Springer, Berlin Heidelberg New York (Handbuch der inneren Medizin, Bd III/3A)

    Google Scholar 

  • Levenson SD, Austin RK, Dietler MD, Kasadra DD, Kagnoff MF (1985) Specificity of antigliadin antibody in coeliac disease. Gastroenterology 89: 1–5

    PubMed  CAS  Google Scholar 

  • Lipkin M, Newmark S (1985) Effect of added dietary calcium on colonic epithelial cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med 313: 1381–1385

    Article  PubMed  CAS  Google Scholar 

  • Little TM (1972) Immunoglobulin levels in families with coeliac disease. Lancet 2: 400

    Article  PubMed  CAS  Google Scholar 

  • Logan RFA, Ferguson A, Finlayson NDC, Weir DG (1978) Primary biliary cirrhosis and celiac disease. Lancet 1: 230–233

    Article  PubMed  CAS  Google Scholar 

  • Logan RFA, Theker G, Rifkind EA, Heading RC, Ferguson A (1983) Changes in clinical features of coeliac disease in adults in Edinburgh and the Lothians 1960–1979. Br Med J 286: 95–97

    Article  CAS  Google Scholar 

  • Lorenzsonn V, Ohlsen WA (1982) In vivo response of rat intestinal epithelium to intraluminal dietary lectins. Gastroenterology 82: 838–842

    PubMed  CAS  Google Scholar 

  • Lorenz-Meyer H, Riecken EO (1978) Angeborene Enzym-and Transportdefekte. In: Riecken EO (Hrsg) Lorenz-Meyer H, Riecken EO, S. E438 - E442 ( Klinik der Gegenwart )

    Google Scholar 

  • Lorenz-Meyer H, Ziegler K, Böger M, Adler G, Rhode H, Brandes W (1980) Quantitative Untersuchungen zur Struktur and Funktion der Dünndarmschleimhaut an endoskopisch gewonnenem Biopsiematerial. Befunde von Patienten mit einheimischer Sprue, mit Zustand nach partieller Dünndarmresektion bei Morbus Crohn and mit Dünndarmresektion aus anderen Gründen. Z Gastroenterol 18: 605–616

    PubMed  CAS  Google Scholar 

  • Lorenz-Meyer H, Roth H, Elsässer P, Hahn U (1985) Cytotoxicity of lectins on rat intestinal mucosa enhanced by neuraminidase. Eur J Clin Invest 15: 227–234

    Article  PubMed  CAS  Google Scholar 

  • Low-Beer TS, Heaton KW, Read AE (1970) Gallblader inertia in adult coeliac disease (abstr). Gut 11: 1057–1058

    Article  PubMed  CAS  Google Scholar 

  • Low-Beer TS, Harvey RF, Davies ER, Read AE (1975) Abnormalities of serum cholecystokinin and gallblader emptying in coeliac disease. N Engl J Med 292: 961–963

    Article  PubMed  CAS  Google Scholar 

  • Lowe G, Johnston RN (1984) Sarcoidosis and coeliac disease. Lancet 2: 637

    Article  PubMed  CAS  Google Scholar 

  • Madara JL, Trier JS (1980) Structural abnormalities of jejunal epithelial cell membranes in coeliac sprue. Lab Invest 43: 254–266

    PubMed  CAS  Google Scholar 

  • Malizia G, Trejdosiewicz LK, Wood GM, Howdle PD, Janossy PD, Losowsky MS (1985) The micro-environment of coeliac disease: cell phaenotypes and expression of the T2 antigen by small bowel lymphocytes. Clin Exp Immunol 60: 437–446

    PubMed  CAS  Google Scholar 

  • Marsh MN (1980) Studies of intestinal lymphoid tissue III Quantitative analysis of epithelial lymphocytes in the small intestine of human control subjects and of patients with coeliac sprue. Gastroenterology 79: 481–492

    PubMed  CAS  Google Scholar 

  • Marsh MN (1984) Morphological expression of immunologically mediated change of injury within the human small intestinal mucosa. In: Batt RM, Lawrence TL (eds) Function and dysfunction of the small intestine. Proc 2nd Durrant Memorial Symposium. University Press, Liverpool, p 167

    Google Scholar 

  • Marsh GW, Stewart JS (1970) Splenic function in adult coeliac disease. Br J Haematol 19: 445–457

    Article  PubMed  CAS  Google Scholar 

  • Marsh MN, Hinde J (1985) Inflammatory component of coeliac sprue mucosa. I. Mastcells, basophils and eosinophils. Gastroenterology 89: 92–100

    PubMed  CAS  Google Scholar 

  • Martin BW (1982) Aspirin for gluten enteropathy. Lancet 2: 1099–1100

    Article  PubMed  CAS  Google Scholar 

  • Mason DW, Dalllmann M, Barclay AN (1981) Graft-versus-host disease induces expression of Ia antigen in rat epidermal cells and gut epithelium. Nature 293: 150–151

    Article  PubMed  CAS  Google Scholar 

  • Maury CPJ, Teppo A-M (1984) Demonstration of tissue 90 kD glucoprotein as antigens in circulating IgG immuncomplexes in dermatitis herpetiformis and coeliac disease. Lancet 2: 892–894

    Article  PubMed  CAS  Google Scholar 

  • Maury CPJ, Teppo A-M, Vuoristo M, Turunen U, Virtanen I (1985) Antibodies to gliadin-binding 90-kDa glycoprotein in coeliac disease. Gut 26: 147–152

    Google Scholar 

  • May RJ, Quaroni A, Kirsch K, Isselbacher KJ (1981) A villus cell-derived inhibitor of intestinal proliferation. Am J Physiol 241: G520

    PubMed  CAS  Google Scholar 

  • McCarthy CF, Fraser ID, Evans KT, Read AE (1966) Lymphoreticular dysfunction in idiopathic steatorrhoea. Gut 7: 140–148

    Article  PubMed  CAS  Google Scholar 

  • McCrae WM (1969) Inheritance of coeliac disease. J Med Genet 6: 129–131

    Article  PubMed  CAS  Google Scholar 

  • McCrae WM, Eastwood MA, Martin MR, Sircus W (1975) Neglected celiac disease. Lancet 1: 187

    Article  PubMed  CAS  Google Scholar 

  • McDonald WC, Brandborg LL, Flick AL, Trier JS, Rubin CE (1984) Studies on coeliac sprue. The response of the whole length of the small bowel to a gluten free diet. Gastroenterology 47: 573–588

    Google Scholar 

  • McNeish AS, Rolles CJ, Arthur LJH (1976) Criteria for diagnosis of temporary gluten intolerance. Arch Dis Child 51: 275–278

    Article  PubMed  CAS  Google Scholar 

  • Meeuwisse GN (1970) Diagnostic criteria in coeliac disease. Discussion European Society for Pediatric Gastroenterology. Acta Paediatr Scand 59: 461–465

    Article  Google Scholar 

  • Melter M, Belitz HD, Gellermann B, Wieser H, Stern M (1988) Handling of gliadin peptides B1–B4 and of cow’s milk proteins by rat jejunum gut sacs. J Ped Gastroenterol Nutr 7: 196–202

    Article  CAS  Google Scholar 

  • Melvin KEW, Hepner GW, Bordier P (1970) Calcium metabolism and bone pathology in adult coeliac disease. Q J Med 39: 83–113

    PubMed  CAS  Google Scholar 

  • Menzies IS (1972) Intestinal permeability in coeliac disease. Gut 13: 847

    PubMed  CAS  Google Scholar 

  • Menzies IS, Noone C, Bull J, Mount JN (1983) Discrimination potential of sugar test for detection of vinous atrophy. Gut 24: 488

    Google Scholar 

  • Miller LJ (1983) Small intestinal manifestation of diabetes mellitus. Yale J Biol Med 56: 189–193

    PubMed  CAS  Google Scholar 

  • Mohammed I, Holborow EJ, Fry L, Thompson BR, Hoffbrand AV, Stewart JS (1976) Multiple immune complexes and hypocomplementaemia in dermatitis herpetiformis and coeliac disease. Lancet II: 487–490

    Google Scholar 

  • Montgomery AMP, Avarette C, Kumar PJ (1986) Expression of class II antigens in coeliac jejuna’ mucosa. Gut 27:Al273

    Google Scholar 

  • Morris JS, Ajduliwicz AB, Read AE (1970) Neurological disorders and adult coeliac disease. Gut 11: 549–554

    Article  PubMed  CAS  Google Scholar 

  • Mothes T, Mühle W, Müller F, Hekkens WTJM (1985) Influence of gliadin on fetal chick intestine in tissue culture. Biol Neonate 48: 59–64

    Article  PubMed  CAS  Google Scholar 

  • Mylotte M, Egan-Mitchell B, McCarthy CF, McNicoll B (1973) Incidence of coeliac disease in the west of Ireland. Br Med J 1: 703–705

    Article  PubMed  CAS  Google Scholar 

  • Nell G (1983) Resorption von Pharmaka. In: Caspary W (Hrsg) Dünndarm, Teil A. Springer, Berlin Heidelberg New York (Handbuch der inneren Medizin, Bd III/3A)

    Google Scholar 

  • Nelson EW, Ertan A, Brooks FP, Carda JJ (1976) Thrombocytosis in patients with coeliac sprue. Gastroenterology 70: 1042–1044

    PubMed  CAS  Google Scholar 

  • Nelson R, McNeish AS, Anderson CM (1973) Coeliac disease in children of Asian immigrants. Lancet 1: 348–350

    Article  PubMed  CAS  Google Scholar 

  • Neutard E, Kluge F (1981) Röntgenologische Veränderungen bei Erwachsenen-Sprue. Radiologe 21: 381–385

    PubMed  CAS  Google Scholar 

  • Nielsen OH, Jacobsen O, Pedersen ER et al. (1985) Non-tropical sprue. Malignant disease and mortality rate. Scand J Gastroenterol 20: 13–18

    Article  PubMed  CAS  Google Scholar 

  • O’Brien CJ, Saverymuttu S, Hodgson HJF, Evans DJ (1983) Coeliac disease, adenocarcinoma of the jejunum and in situ squamous carcinoma of the oesophagus. J Clin Pathol 36: 62–67

    Article  PubMed  Google Scholar 

  • O’Farrelly C, Feighery C, Greally JF, Weir DG (1982) Cellular response to alpha gliadin in untreated coeliac disease. Gut 23: 83–87

    Article  PubMed  Google Scholar 

  • O’Farrelly C, Hekkens WTJM, Feighery C, Weir DG (1983) The specificity of wheat protein reactivity in coeliac disease.

    Google Scholar 

  • O’Farrelly C, Whelan CA, Feighery CF, Weir DG (1984a) Suppressor-cell activity in coeliac disease induced by alpha-gliadin, a dietary antigen. Lancet 2: 1305–1307

    Article  PubMed  Google Scholar 

  • O’Farrelly C, McKeever U, Weir DG (1984b) Increased concanavalin A induced suppression in treated and untreated coeliac disease. Gut 25: 644–648

    Article  PubMed  Google Scholar 

  • O’Grady JG, Stevens FM, Harding Bet al. (1984a) Hyposplenism and gluten sensitive enteropathy. Gastroenterology 87: 1326–1331

    PubMed  Google Scholar 

  • O’Grady JG, Stevens FM, Keane R et al. (1984b) Intestinal lactase, sucrase and alkaline phosphatase in 373 patients with coeliac disease. J Clin Pathol 37: 298–301

    Article  PubMed  Google Scholar 

  • O’Donoghue DP, Lancaster-Smith M, Laviniere P, Kumar PJ (1976) T cell depletion in untreated coeliac disease. Gut 17: 328–331

    Article  PubMed  Google Scholar 

  • Ottoway CA, Bienenstock J (1986) Mucosal immunity. Immunol Today

    Google Scholar 

  • Padyikula HA, Strauss EW, Ladman AJ, Gardner FH (1961) A morphological and histochemical analysis of the human jejunal epithelium in nontropical sprue. Gastroenterology 40: 735–752

    Google Scholar 

  • Pallis CA, Lewis PD (1974) The neurology of gastrointestinal disease. Saunders, London, pp 138–156

    Google Scholar 

  • Pena AS, Mann DL, Hague NE et al. (1976) Genetic basis of gluten sensitive enteropathy. Gastroenterology 75: 230–235

    Google Scholar 

  • Perez-Jimenez F, Lopez PB, Tallo EP et al. (1981) Selective IgA-deficiency and the HLA-B8 antigen. Report of 2 cases with familial data. Arch Intern Med 141: 509–513

    Article  PubMed  CAS  Google Scholar 

  • Peters TJ, Jones PE, Wells G (1978) Analytical sub cellular fractionation of jejunal biopsy specimens: enzyme activities, organell pathology, and response to gluten withdrawal in patients with coeliac disease. Clin Sci Mol Med 55: 285–292

    PubMed  CAS  Google Scholar 

  • Peyrot M, Desjeux FG, Millet F, Bessard C, Lestradet (1981) Reduction of bile salt secretion in children with coeliac disease in activity and in remission. Helv Paediatr Acta 36: 509–518

    PubMed  CAS  Google Scholar 

  • Pietroletti R, Bishop AE, Carlei F et al. (1986) Gut endocrine cell population in coeliac disease estimated by immunocytochemistry using a monoclonal antibody to chromagranin. Gut 27: 838–843

    Article  PubMed  CAS  Google Scholar 

  • Pignata C, Troncone R, Monaco G et al. (1985) Impaired suppressor activity in children affected by coeliac disease. Gut 26: 285–290

    Article  PubMed  CAS  Google Scholar 

  • Plotkin JM, Isselbacher KJ (1976) Secondar disacchidase deficiency in adult coeliac disease (nontropical sprue) and other malabsorption states. N Engl J Med 271: 1033–1037

    Article  Google Scholar 

  • Polak JM, Pearse AGE, Noorden S, Bloom SR, Rossiter MA (1973a) Secretin cells in coeliac disease. Gut 14: 870–874

    Article  PubMed  CAS  Google Scholar 

  • Polak JM, Bloom SR, Kuzio M, Brown JG, Pearse GE (1973b) Cellular lokalisation of gastric inhibitory polypeptide in the duodenum and jejunum. Gut 14: 284–288

    Article  PubMed  CAS  Google Scholar 

  • Polanco I, Biemond I, Van Leeuwen A (1981) Glutensensitive enteropathy in Spain: genetic and environmental factors. In: McConnell RB (ed) The genetics of coeliac disease. Lancaster, England, MTP Press, pp 211–231

    Google Scholar 

  • Pollock DJ (1977) The liver in coeliac disease. Histopathology 1: 421–430

    Article  PubMed  CAS  Google Scholar 

  • Potten CS, Chwalinski S, Swindell R, Palmer M (1982) The spatial organisation of the hierarchical proliferative cells of the crypts of the small intestine into clusters of synchronized cells. Cell Tissues Kinet 15: 351–370

    CAS  Google Scholar 

  • Prizont R, Hersh T, Floch MH (1970) Jejunal bacterial flora in chronic small bowel disease. I Coeliac disease. II Regional enteritis. Am J Clin Nutr 23: 1602–1607

    PubMed  CAS  Google Scholar 

  • Quaroni A (1985a) Crypt cell development in newborn rat small intestine. J Cell Biol 100: 1601–1610

    Article  PubMed  CAS  Google Scholar 

  • Quaroni A (1985b) Development of fetal rat intestine in organ and monolayer culture. J Cell Biol 100: 1611–1622

    Article  PubMed  CAS  Google Scholar 

  • Quaroni A (1986) Fetal characteristics of small intestinal crypt cells. Proc Natl Acad Sci USA 83: 1723–1727

    Article  CAS  Google Scholar 

  • Rampal P, Nano IL, Zunino C (1987) Inhibition of intestinal cell proliferation by villous cell extract. Gut 28 S1: 109–115

    Google Scholar 

  • Rask-Madsen J (1986) Eicanosoids and their role in the pathogenesis of diarrhoea) diseases. Clin Gastroenterol 15: 545

    PubMed  CAS  Google Scholar 

  • Rawcliffe PM, Jewell DP, Faux JA (1985) Specific IgG subclass antibodies and IgG S-TS antibodies to wheat gluten fraction B in patients with coeliac disease. Clin Allergy 15: 155–162

    Article  PubMed  CAS  Google Scholar 

  • Regan PT, DiMango EP (1980) Exocrine pancreatic insufficiency in celiac sprue: a cause of treatment failure. Gastroenterology 78: 484–487

    PubMed  CAS  Google Scholar 

  • Reinhart WH, Müller O, Halter F (1983) Influence of long-term 16,16-dimethyl prostaglandine EZ treatment on the rat gastrointestinal mucosa. Gastroenterology 85: 1003–1010

    PubMed  CAS  Google Scholar 

  • Riecken EO (1970) Vergleichende bioptische Untersuchungen zur formalen Pathogenese der Dünndarmschleimhautveränderungen bei der einheimischen Sprue. Klin Wochenschr 20: 1216–1225

    Article  Google Scholar 

  • Riecken EO (1978) Primäres Malabsorptionssyndrom (einheimische Sprue. In: Riecken EO (Hrsg) Riecken EO, S. 452 ( Klinik der Gegenwart )

    Google Scholar 

  • Riecken EO (1983) Tropische Sprue. In: Caspary W (Hrsg) Der Dünndarm, Teil B. Springer, Berlin Heidelberg New York, S. 33–46 (Handbuch der inneren Medizin, Bd III/3B)

    Google Scholar 

  • Riecken EO, Sahifeld M, Lorenz-Meyer H (1976) Quantitative Untersuchungen zur dreidimensionalen Dünndarmschleimhautveränderung bei Gesunden und Patienten mit einheimischer Sprue. Dtsch Med Wochenschr 101: 51–53

    Article  PubMed  CAS  Google Scholar 

  • Riemann JF, Hoffmann KP (1978) Kollagene Sprue. Dtsch Med Wochenschr 103: 685–688

    Article  PubMed  CAS  Google Scholar 

  • Ritchie JA, Salem SN (1965) Upper intestinal motility in ulcerative colitis, idiopathic steatorrhoea, and irritable colon syndrome. Gut 6: 325–327

    Article  PubMed  CAS  Google Scholar 

  • de Ritis G, Occarsio P, Auricchio S et al. (1979) Toxicity of wheat flour proteins and protein derived proteins fon in vitro developing intestinae from rat fetus

    Google Scholar 

  • Robinson JWL, Mirkovitch V, Winistörfer B, Saegesser F (1981) Response of the intestinal mucosa to ischaemia. Gut 22: 512–527

    Article  PubMed  CAS  Google Scholar 

  • Robinson TJ (1976) Coeliac disease with farmer’s lung. Br Med J 1: 745–746

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal E, Golan DT, Benderly A, Shmuel Z, Levy J (1984) Immunfluorescent antigluten antibody test. AJDC 138: 659

    PubMed  CAS  Google Scholar 

  • Rubin CE, Brandborg LL, Phelps PC, Taylor HC (1960) Studies of the celiac disease. I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue. Gastroenterology 38: 28–49

    PubMed  CAS  Google Scholar 

  • Rubin CE, Brandborg LL, Flick AL et al. (1962) Biopsy studies on the pathogenesis of coeliac sprue. In: Intestinal biopsy. Little, Brown, Boston, p 67

    Google Scholar 

  • Rubin W, Ross LL, Sleiseuger MH, Weser E (1966) An electron microscopic study of adult coeliac disease. Lab Invest 15: 1720–1747

    PubMed  CAS  Google Scholar 

  • Ruppin H, Bär-Meir S, SoergelKH,Wood CM, Schmidtt MG (1980) Absorption of short chain fatta acids by the colon. Gastroenterology 78: 1500–1507

    PubMed  CAS  Google Scholar 

  • Ruppin H (1985) Current aspects of intestinal motility and transport. Klin Wochenschr 63: 679–688

    Article  PubMed  CAS  Google Scholar 

  • Schedl HP, Clifton JA (1963) Solute and water absorption by the human small intestine. Nature 199: 1264–1267

    Article  PubMed  CAS  Google Scholar 

  • Schedl HP, Pierce CE, Rider A, Clifton JA (1968) Absorption of I-methionin from human small intestine. J Clin Invest 47: 417–425

    Article  PubMed  CAS  Google Scholar 

  • Schmid WC, Phillips SF, Summerskill WHJ (1969) Jejunal secretion of electrolytes and water in nontropical sprue. J Lab Clin Med 73: 772–783

    PubMed  CAS  Google Scholar 

  • Schott GD, Wills MR (1976) Muscle weakness in osteomalacia. Lancet 1: 626–629

    Article  PubMed  CAS  Google Scholar 

  • Schrier PI, Bernards R, Vaessen RTMJ, Houweling A, Van der Eb AJ (1983) Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells. Nature (London) 305: 771

    Article  CAS  Google Scholar 

  • Schuster S, Watson AJ, Marks J (1978) Coeliac syndrome in dermatitis herpetiformis. Lancet I: 1101–1106

    Google Scholar 

  • Scott BB, Losowski MS (1975) Coeliac disease, a cause of various associated disease? Lancet 2: 956–957

    Article  PubMed  CAS  Google Scholar 

  • Scott BB, Goodall A, Stephenson P, Jenkins D (1984) Small intestinal plasmacells in coeliac disease. Gut 25: 41–46

    Article  PubMed  CAS  Google Scholar 

  • Scott H, Fausa O, Brandtzaeg EK, Brandtzaeg P (1984) Immunresponse pattern in coeliac disease. Serum antibodies to dietary antigens measured by an enzyme linked immunosorbent assay. Clin Exp Immunol 57: 25–32

    PubMed  CAS  Google Scholar 

  • Seaman WB, Fleming RJ, Baker DH (1966) Pneumatosis intestinalis of the small bowel. Semin Roentgenol 1: 234–242

    Article  Google Scholar 

  • Selby WS, Janossy G, Jewell DP (1981) Immunhistological characterisation of intraepithelial lymphocytes of the gastrointestinal tract. Gut 22: 169–176

    Article  PubMed  CAS  Google Scholar 

  • Selby WS, Janossy G, Bofill M, Jewell DP (1983) Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa of patients with adult coeliac disease. Clin Exp Immunol 52: 219–228

    PubMed  CAS  Google Scholar 

  • Shale DJ, Johnston DG, Hall R, Robert DF (1982) Coeliac disease in monozygotic twins. Postgrad Med J 58: 797–798

    Article  PubMed  CAS  Google Scholar 

  • Shanahan F, McKenna R, McCarthy CF, Drury MI (1982) Coeliac disease and diabetes mellitus. A study of 24 patients with HLA-typing. Q J Med 203: 329–335

    Google Scholar 

  • Shiner M (1973) Ultrastructural changes suggesting of immune reactions in the jejunal mucosa of coeliac children following gluten challenge. Gut 14: 1–12

    Article  PubMed  CAS  Google Scholar 

  • Shiner M (1974) Electron microscopy of jejunal mucosa in coeliac disease. Clin Gastroenterol 3: 33–51

    PubMed  CAS  Google Scholar 

  • Shiner M (1983) Ultrastructure of the small intestinal mucosa. Springer, Berlin Heidelberg New York

    Book  Google Scholar 

  • Shiner M, Ballard J (1972) Antigen-antibody reactions in jejunal mucosa in childhood coeliac disease after gluten challenge. Lancet 1: 1202–1205

    Article  PubMed  CAS  Google Scholar 

  • Shuster S, Watson AJ, Marks J (1968) Coeliac syndrome in dermatitis herpetiformis. Lancet I: 1101–1106

    Google Scholar 

  • Sikora F, Anand BS, Truelove SC, Ciclitera PJ, Offord RE (1976) Stimulation of lymphocytes from patients with coeliac disease by a substraction of gluten. Lancet 2: 389–391

    Article  PubMed  CAS  Google Scholar 

  • Silk DBA, Kumar PJ, Perret D, Clark ML, Dawson AM (1974) Aminoacids and peptide absorption in patients with coeliac disease and dermatitis herpetiformis. Gut 15: 1

    Article  PubMed  CAS  Google Scholar 

  • Simmonds JP, Rosenthal FD (1981) Lymphadenopathy in coeliac disease. Gut 22: 756–758

    Article  PubMed  CAS  Google Scholar 

  • Singh AK (1970) Excretion of endogenous non haem iron by the gastrointestinal tract in hum subjects and its influence on the size of the bodystore iron with particular influence to celiac disease. Br J Haematol 18: 597–609

    Article  PubMed  CAS  Google Scholar 

  • Sjöklund K, Alumets J, Berg N-O, Hakanson R, Sundler F (1982) Enteropathy of coeliac disease in adults: increased number of enterochromaffin cells in the duodenal mucosa. Gut 23: 43–48

    Google Scholar 

  • Smith GS, Warhurst, Turnberg LA (1982) Synthesis and degradation of prostaglandine E2 in the epithelial and subepithelial layers of the rat intestine. Biochim Biophys Acta 713: 684–687

    PubMed  CAS  Google Scholar 

  • Smith R, Stern G (1967) Myopathy, osteomalacia and hyperparathyreoidism. J Neurol Sci 8: 511–520

    Article  Google Scholar 

  • Solomons NW, Rosenberg TT, Sandstaed HH (1976) Zinc nutrition in coeliac sprue. Am J Clin Nutr 29: 371–375

    PubMed  CAS  Google Scholar 

  • Spiro HM (1977) Clinical gastroenterology. NW, Toronto, p 516

    Google Scholar 

  • Stallmach A, Belitz HD, Gellermann B, Schäfer H, Wieser H, Stern M (1987) Effects of gliadin peptides B, -B4 in coeliac disease. I Organ culture studies. J Ped Gastr Nutr 6: 335–340

    Article  CAS  Google Scholar 

  • Stanisz AM, Befus D, Bienenstock J (1986) Differential effects of vasoactive intestinal peptide, substance P and somatostatin on immunglobulin synthesis and proliferation by lymphocytes from Peyer’s plaques, mesenteric lymphodes and spleen. J Immunol 136: 152–156

    PubMed  CAS  Google Scholar 

  • Stern M (1985) Concepts in coeliac disease: Is there a receptor for gliadin? Klin Pädiatr 197: 349–354

    Article  PubMed  CAS  Google Scholar 

  • Stern M, Gellermann B (1987) Food proteins and maturation of small intestinal microvillus membranes I I. Binding of gliadin hydrolysate fractions. Pediatr Res

    Google Scholar 

  • Stewart JS (1974) Clinical and morphological response to gluten withdrawal. Clin Gastroenterol 3: 109

    PubMed  CAS  Google Scholar 

  • Stewart JS, Pollock DJ, Hoffbrand AV, Moulin DL, Booth CC (1967) A study of proximal and distal intestinal structure and absorptive function in idiopathic steatorrhoea. Q J Med 36: 425–444

    PubMed  CAS  Google Scholar 

  • Strober W (1985) Glutensensitive enteropathy — an abnormal immunologic response of the gastrointestinal tract to a dietary protein. Gastrointestinal immunity for the children. Mayo Foundation 75

    Google Scholar 

  • Stubbs WA, Jones A, Edwards CRW et al. (1978) Hormonal and metabolic responses to an enkephalin analogue in normal man. Lancet 2: 1225–1227

    Article  PubMed  CAS  Google Scholar 

  • Tarlo SMM, Broder I, Prokepchuk EJ, Peres L, Mintz S (1981) Association between coeliac disease and lung disease. Chest 80: 715–718

    Article  PubMed  CAS  Google Scholar 

  • Teppo AM, Maury CPJ (1984) Enzyme immunoassay of antibodies to epithelial glucoprotein: Increased level of antibodies in coeliac disease. J Immunol Methods 74: 327–336

    Article  PubMed  CAS  Google Scholar 

  • Thain ME, Hamilton JR, Ehrlich RM (1974) Coexistence of diabetes mellitus and coeliac disease. J Paediatr 85: 527–529

    Article  CAS  Google Scholar 

  • Thayssen, Hess (1982) The nontropical sprue

    Google Scholar 

  • Thompson DG, Lennard-Jones JE, Swarbrik ET, Brown R (1979) Pericarditis and inflammatory bowel disease. Q J Med 189: 93–97

    Google Scholar 

  • Timpl R, Wick G, Granditsch G (1977) Reticulin antibodies in childhood coeliac disease not directed against type III collagen. Clin Exp Immunol 28: 546–547

    PubMed  CAS  Google Scholar 

  • Trier JS (1978) Coeliac sprue disease. In: Sleisinger MH, Fordtran JS (eds) Gastrointestinal disease. Saunders, Philadelphia, pp 1029–1051

    Google Scholar 

  • Tully TE, Feinberg SB (1974) A roentgenographic classification of diffuse diseases of the small intestine presenting with malabsorption. Radiology 121: 283–290

    CAS  Google Scholar 

  • Unsworth DJ, Kieffer M, Holborrow EJ, Coombs RRA, Walker-Smith JA (1981) TGA antigliadine antibodies in coeliac disease. Clin Exp Immunol 46: 286–298

    PubMed  CAS  Google Scholar 

  • Unsworth DJ, Walker-Smith JA, Holborow (1983) Gliadin and reticulin antibodies in childhood coeliac disease. Lancet 1: 874–875

    Article  PubMed  CAS  Google Scholar 

  • Vanderhoek JY, Tare NS, Bailey JM et al. (1982) New role for 15-hydroxyeicosatetraenoic acid. J Biol Chem 257: 12191–12195

    PubMed  CAS  Google Scholar 

  • Vanderschueren-Lodewieyckx M, Wolter R, Eggermont E, Eeckels R (1973) Plasma growth hormone in coeliac disease. Helv Paediatr Acta 28: 349–357

    Google Scholar 

  • van de Kamer JH, Weijers HA, Dicke WK (1953) Coeliac disease: investigation of harm full effects of certain types of cereal on patients with coeliac disease. Acta Pediatr 42: 233

    Article  Google Scholar 

  • Visakorpi JK, Immonen P (1967) Intolerance to cow’s milk and wheat gluten in the primary malabsorption syndrome in infancy. Acta Paeditr Scand 56: 49–56

    Article  Google Scholar 

  • Visakorpi JK, Savilahti E (1970) A clinical morphological study of the permanence of gluten intolerance. In: Booth CC, Dowling RH (eds) Coeliac disease. Churchill Livingstone, Edinburgh, pp 224–230

    Google Scholar 

  • Volta U, Cassani F, Franchis RD et al. (1984) Antibodies to gliadin in adult coeliac disease and dermatitis herpetiformis. Digestion 30: 263–270

    Article  PubMed  CAS  Google Scholar 

  • Walsh CH, Cooper BT, Wright AD, Malins JM, Cooke WT (1978) Diabetes mellitus and coeliac disease: a clinical study. Q J Med 185: 89–100

    Google Scholar 

  • Wardrop CAJ, Dagg JH, Lee FD, Sing H, Dyet JF, Moffat A (1975) Immunological abnormalities in splenic atrophy. Lancet 2: 4–7

    Article  PubMed  CAS  Google Scholar 

  • Weinstein WM, Saunders DR, Tytgat GN, Rubin CE (1970) Collagenous sprue — an unrecognized type of malabsorption. N Engl J Med 283–1297

    Google Scholar 

  • Weinstein WM, Brown JR, Parker F, Rubin CE (1971) The small intestinale mucosa in dermatitis herpetiformis. II Relationship of the small intestinal lesion to gluten. Gastroenterology 60: 362–369

    CAS  Google Scholar 

  • Weiser M (1983) Is gluten a plant lectin and if so does this property relate to coeliac disease? Gastroenterology 85: 206–207

    Google Scholar 

  • Weiser MM, Douglas AP (1976) An alternative mechanism of gluten toxicity in coeliac disease. Lancet 1: 567–569

    Article  PubMed  CAS  Google Scholar 

  • Weiß JB, Austin RK, Shanfield MS, Kagnoff M (1983) Glutensensitive enteropathy. Immunglobuline G heavy chain ( GM) allotypes and the immune response to wheat gliadine. J Clin Invest 72: 96–101

    Article  PubMed  Google Scholar 

  • Wewer U, Liotta LA, Jaye M, Ricca GA et al. (1986) Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc Natl Acad Science 83: 7137–7141

    Article  CAS  Google Scholar 

  • Wieser H, Berlitz HD, Ashkenazi A (1984) Amino-acid sequence of the coeliac active gliadin peptide B 3142. Z Lebensm Unters Forsch 179: 371–376

    Article  PubMed  CAS  Google Scholar 

  • Willet WC, Polk BF, Morris JS et al. (1983) Praediagnostic serum selenium and risk of cancer. Lancet 1: 130–134

    Article  Google Scholar 

  • Williams A, Asquith P, Edwards C, Stableforth DE (1984) Alveolitis in adult coeliac disease — a new syndrome. Thorax 39: 219

    Google Scholar 

  • Wood GM, Shires S, Howdle PD, Losowsky MS (1986) Immunglobulin production by coeliac biopsies in organ culture. Gut 27: 1151–1160

    Article  PubMed  CAS  Google Scholar 

  • Wormsley KD (1970) Response to duodenal acidification in man III. Comparison with effects of secretin and pancreocymin. Scand J Gastroenterol 5: 353–360

    PubMed  CAS  Google Scholar 

  • Wright NA, Watson AJ, Morley AR et al. (1973) Cell kinetics in flat (avillous) mucosa of the human small intestine. Gut 14: 701–710

    Article  PubMed  CAS  Google Scholar 

  • Yardley JH, Bayless TM, Norton JH (1962) A study of the jejunal epithelium before and after a gluten-free diet. New Engl J Medicine 267: 1173–1179

    Article  CAS  Google Scholar 

  • Young WT, Pringle EM (1971)110 children with celiac disease 1950–1969. Arch Dis Child 46: 421

    Google Scholar 

  • Zinkernagel M (1986) Major histocompatibility gene complex-disease associations may reflect T cell-mediated immunopathology. Eur J Clin Invest 16: 101–105

    Article  PubMed  CAS  Google Scholar 

  • Zioudrou C, Streaty RA, Klee WA (1979) Opiois peptides derived from food proteins. In Exorphins. J Biol Chem 254: 2446–2449

    PubMed  CAS  Google Scholar 

  • Isacson PG et al. (1985) Malignant histiocytosis of the intestine: a T cell lymphoma. Lancet 1: 688–91

    Article  Google Scholar 

  • Stein H, Dienemann D, Sperling M, Zeitz M, Riecken EO (1988) Identification of a T Cell Lymphoma category derived from Intestinal-Mucosa-Associated T Cells. Lancet 2: 1053–54

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Akademisches Lehrkrankenhaus, Röntgenstr. 2, D-7990, Friedrichshafen, Deutschland

    H. Lorenz-Meyer

  2. Medizinische Uniklinik, D-8520, Erlangen, Deutschland

    U. Hahn

Authors
  1. H. Lorenz-Meyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Hahn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

M. Brandis P. Frick K. Kochsiek G. A. Martini A. Prader

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Lorenz-Meyer, H., Hahn, U. (1989). Die einheimische Sprue. In: Brandis, M., Frick, P., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics, vol 58. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74042-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74042-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74043-5

  • Online ISBN: 978-3-642-74042-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation