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The Alpha-2 Adrenoceptor Vulnerability Hypothesis of Depression: From the Clonidine Growth Hormone Stimulation Test to the Genes Encoding a Human Alpha-2 Adrenoceptor and Phenylethanolamine N-Methyltransferase

  • M. R. Hoehe
  • L. R. Goldin
  • E. E. Baetge
  • K.-U. Lentes
  • W. H. Berrettini
Conference paper

Abstract

The pharmacological challenge has been a major approach for generating and testing pathophysiological hypotheses in depression. A classical paradigm has been the clonidine (CLON) growth hormone (GH) stimulation test: the selective alpha-2 adrenoceptor agonist CLON has been used as a tool to test alpha-2 adrenoceptor function, generating the alpha-2 adrenoceptor hypothesis of depression. As the CLON-induced GH secretion was shown to reflect alpha-2 adrenoceptor sensitivity (Terry and Martin 1981; Eriksson et al. 1982), the GH response to CLON has been considered a valid indication of hypothalamic alpha-2 adrenoceptor function.

Keywords

Growth Hormone Response Recombination Fraction Euthymic Patient Pathophysiological Hypothesis PNMT Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. R. Hoehe
    • 1
  • L. R. Goldin
    • 1
  • E. E. Baetge
    • 2
  • K.-U. Lentes
    • 3
  • W. H. Berrettini
    • 1
  1. 1.Clinical Neurogenetics BranchNIMH, NIHBethesdaUSA
  2. 2.Howard Hughes Medical InstituteUniversity of WashingtonSeattleUSA
  3. 3.Institute for Human GeneticsUniversität BonnBonn 1Germany

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