AIDS as a Neuropeptide Disorder: Does HIV Bind to a VIP Receptor?
By mimicking the molecular structure of the binding site of a neurotransmitter or other endogenous ligand, viruses are known to bind to the receptor of that neurotransmitter and, by subsequent steps, infect the receptor-bearing cells. Toxic effects may also occur to cells when shed viral proteins, although not infectious, bind to a receptor site and block the functions of the endogenous ligand (see recent review by Lentz 1988).
KeywordsHuman Immunodeficiency Virus Vasoactive Intestinal Peptide Vasoactive Intestinal Polypeptide Vasoactive Intestinal Peptide Receptor Mammillary Nucleus
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