Neurotransmitter Function in Post-Mortem Human Brain: An Overview

  • C. J. Fowler
  • R. F. Cowburn
  • J. A. Hardy
  • P. Wester
  • B. Winblad
Conference paper

Abstract

Use of post-mortem human brain samples in research is associated with a number of advantages and disadvantages. The two main advantages are (a) that the disease process in question can be studied per se instead of using animal models, the relevance of which are sometimes doubtful (for discussion, see Willner 1984; Fowler et al. 1988), and (b) that the observed neurochemical changes can be correlated with symptomatology. Disadvantages include the fact that autopsy samples represent the end point of the disease, where secondary symptoms may play an obfuscatory role. In addition, interpretation of findings is hindered by a number of factors, such as drug treatment, agonal state and post-mortal stability, that must be taken into account. Finally, the nature of the samples, and the necessity for their storage, rules out a number of assays (for further discussion, see Hardy and Dodd 1983; Perry and Perry 1983; Lee 1988).

Keywords

Dementia Schizophrenia Histamine Choline Cyclohexane 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. J. Fowler
    • 1
    • 2
  • R. F. Cowburn
    • 1
  • J. A. Hardy
    • 3
  • P. Wester
    • 4
    • 5
  • B. Winblad
    • 1
    • 2
  1. 1.Department of Geriatric Medicine, Karolinska InstitutetHuddinge SjukhusHuddingeSweden
  2. 2.Research and Development LaboratoriesAstra Research Centre ABSödertäljeSweden
  3. 3.Biochemistry DepartmentSt. Mary’s Hospital Medical SchoolLondonUK
  4. 4.Department of Internal MedicineUniversity of UmeåUmeåSweden
  5. 5.Department of PathologyUniversity of UmeåUmeåSweden

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