Abstract
The spontaneous confidential reporting of adverse drug reactions (ADRs) used in several countries has the advantage of being cheap and effective in drawing attention to unusual and unexpected reactions with new drugs. No system is perfect, and open reporting systems have their limitations. It is recognised that one of their important problems is the likelihood that for a number of reasons serious ADRs may be underreported.
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References
Asberg M, Traskman L, Thoren P (1976) 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Arch Gen Psychiatr 33: 1193–1197
Cassidy S, Henry J (1987) Fatal toxicity of antidepressant drugs in overdose. Br Med J 295: 1021–1024
Committee on Safety of Medicines (1985) Adverse reactions to antidepressants. Br Med J 291: 1638
Committee on Safety of Medicines (1988) Benzodiazepines, dependence and withdrawal symptoms. Current Problems 21
de Wilde J, Mertens C, Fredricson Overo K, Hepfner Petersen HE (1985) Citalopram versus mianserin, a controlled double-blind trial in depressed patients. Acta Psychiatr Scand 72: 89–96
Dillier N (1982) Worldwide clinical experience with Ludiomil. Act Nerv Super (Praha) 24: 40–52
Gardner DL, Cowdry RW (1985) Alprazolam-induced dyscontrol in borderline personality disorder. Am J Psychiatry 142: 98–100
Geltzer J (1986) Limits to chemotherapy of depression. Psychopathology 19: 108–117
Linnoila M, Virkkunen M, Scheinin M, Muutila A, Rimon R, Goodwin FK (1984) Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behaviour. Life Sci 33: 2609–2414
Montgomery SA, Pinder RM (1987) Do some antidepressants promote suicide? Psychopharmacology 92: 265–266
Montgomery SA, McAuley R, Rani SJ, Roy D, Montgomery D (1981) A double blind comparison of zimelidine and amitriptyline in endogenous depression. Acta Psychiatr Scand 63 [Suppl 290]: 314–327
Muijen M, Roy D, Silverstone T, Mehmet A, Christie M (1988) A comparative clinical trial of fluoxetine, mianserin, and placebo with depressed outpatients. Acta Psychiatr Scand 78: 384–390
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© 1990 Springer-Verlag Berlin Heidelberg
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Montgomery, S.A., Baldwin, D., Fineberg, N. (1990). Relative Toxicity of Antidepressants Using Reports Independent of Observer Bias. In: Bunney, W.E., Hippius, H., Laakmann, G., Schmauss, M. (eds) Neuropsychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74034-3_55
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DOI: https://doi.org/10.1007/978-3-642-74034-3_55
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