Relative Toxicity of Antidepressants Using Reports Independent of Observer Bias

  • S. A. Montgomery
  • D. Baldwin
  • N. Fineberg

Abstract

The spontaneous confidential reporting of adverse drug reactions (ADRs) used in several countries has the advantage of being cheap and effective in drawing attention to unusual and unexpected reactions with new drugs. No system is perfect, and open reporting systems have their limitations. It is recognised that one of their important problems is the likelihood that for a number of reasons serious ADRs may be underreported.

Keywords

Placebo Toxicity Fluoxetine Tricyclic Imipramine 

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References

  1. Asberg M, Traskman L, Thoren P (1976) 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Arch Gen Psychiatr 33: 1193–1197PubMedCrossRefGoogle Scholar
  2. Cassidy S, Henry J (1987) Fatal toxicity of antidepressant drugs in overdose. Br Med J 295: 1021–1024CrossRefGoogle Scholar
  3. Committee on Safety of Medicines (1985) Adverse reactions to antidepressants. Br Med J 291: 1638CrossRefGoogle Scholar
  4. Committee on Safety of Medicines (1988) Benzodiazepines, dependence and withdrawal symptoms. Current Problems 21Google Scholar
  5. de Wilde J, Mertens C, Fredricson Overo K, Hepfner Petersen HE (1985) Citalopram versus mianserin, a controlled double-blind trial in depressed patients. Acta Psychiatr Scand 72: 89–96PubMedCrossRefGoogle Scholar
  6. Dillier N (1982) Worldwide clinical experience with Ludiomil. Act Nerv Super (Praha) 24: 40–52Google Scholar
  7. Gardner DL, Cowdry RW (1985) Alprazolam-induced dyscontrol in borderline personality disorder. Am J Psychiatry 142: 98–100PubMedGoogle Scholar
  8. Geltzer J (1986) Limits to chemotherapy of depression. Psychopathology 19: 108–117CrossRefGoogle Scholar
  9. Linnoila M, Virkkunen M, Scheinin M, Muutila A, Rimon R, Goodwin FK (1984) Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behaviour. Life Sci 33: 2609–2414CrossRefGoogle Scholar
  10. Montgomery SA, Pinder RM (1987) Do some antidepressants promote suicide? Psychopharmacology 92: 265–266PubMedCrossRefGoogle Scholar
  11. Montgomery SA, McAuley R, Rani SJ, Roy D, Montgomery D (1981) A double blind comparison of zimelidine and amitriptyline in endogenous depression. Acta Psychiatr Scand 63 [Suppl 290]: 314–327CrossRefGoogle Scholar
  12. Muijen M, Roy D, Silverstone T, Mehmet A, Christie M (1988) A comparative clinical trial of fluoxetine, mianserin, and placebo with depressed outpatients. Acta Psychiatr Scand 78: 384–390PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. A. Montgomery
  • D. Baldwin
  • N. Fineberg
    • 1
  1. 1.Department of PsychiatrySt. Mary’s HospitalLondonUK

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