Corticotropin-Releasing Hormone and the Proopiomelanocortin-Derived Peptides in Depression

  • B. G. Charlton
  • I. N. Ferrier
Conference paper


A wide range of abnormalities of the hypothalamo-pituitary-adrenal (HPA) axis have been described in depressed subjects. This chapter reviews these abnormalities and attempts to synthesise them into a testable hypothesis.


ACTH Secretion Dexamethasone Suppression Test Suicide Victim Depressed Subject Bioi Psychiatry 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • B. G. Charlton
    • 1
  • I. N. Ferrier
    • 2
  1. 1.Anatomy DepartmentGlasgow UniversityGlasgowUK
  2. 2.MRC Neurochemical Pathology UnitNewcastle General HospitalNewcastle-upon-TyneUK

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