Gene Expression of Opioid Peptides is Regulated by Electrical Activity
A fundamental question in neurobiology is how the level of gene expression within neurones is regulated by the electrical and neurochemical signals that they receive. In the simplest model, depolarization of the cell membrane may lead not only to neurotransmitter release but also to an altered rate of transmitter synthesis. In this paper we summarize our recent data showing that depolarization of neuronal, sympathetic, and endocrine cells alter the levels of mRNA coding for the opioid peptide precursors proopiomelanocortin (POMC), proenkephalin, and prodynorphin in vitro or in vivo.
KeywordsLithium Electrophoresis Dexamethasone Nylon Myeloma
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