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Antithyroid Antibodies: Behavioral Significance

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Neuropsychopharmacology

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Abstract

A variety of disturbances in thyroid regulation, ranging in nature from subtle to overt, have been reported in patients with primary psychiatric diagnoses (Loosen 1986; Zach and Ackerman 1988). The continuing dilemma in interpretation of these findings centers on whether they represent isolated and unrelated disturbances in hormonal regulation or are rather varying functional presentations of an underlying central defect in a significant percentage of the population under study. A key advance in this regard has been the recognition in recent years that the majority of thyroid abnormalities evolve from a genetically transmitted alteration in immune regulation (Weetman and McGregor 1984). The development of autoimmune thyroid disease is a complex and progressive process, most likely involving an organic specific defect in suppressor T-lymphocytes, aberrant expression of HLA antigens on the membranes of thyroid cells, and one or more environmental precipitating stimuli, in addition to the genetic factors already mentioned. Abnormalities in thyroid metabolism and function are relatively late sequelae of this pathologic change of events.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Langley Porter Neuropsychiatric Institute, University of California School of Medicine, 401 Parnassus Avenue, Box F, San Francisco, CA, 94143, USA

    N. Freimer

Authors
  1. V. I. Reus
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  2. N. Freimer
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Editor information

Editors and Affiliations

  1. College of Medicine, University of California at Irvine, 92717, Irvine, CA, USA

    W. E. Bunney Jr. M. D. (Professor of Psychiatry) (Professor of Psychiatry)

  2. Psychiatrische Klinik und Poliklinik, Universität München, Nußbaumstraße 7, 8000, München 2, Germany

    Hanns Hippius  & Gregor Laakmann  & 

  3. Bezirkskrankenhaus Augsburg, Dr.-Mack-Straße 1, 8900, Augsburg, Germany

    Max Schmauss

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© 1990 Springer-Verlag Berlin Heidelberg

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Reus, V.I., Freimer, N. (1990). Antithyroid Antibodies: Behavioral Significance. In: Bunney, W.E., Hippius, H., Laakmann, G., Schmauss, M. (eds) Neuropsychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74034-3_36

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  • DOI: https://doi.org/10.1007/978-3-642-74034-3_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74036-7

  • Online ISBN: 978-3-642-74034-3

  • eBook Packages: Springer Book Archive

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