Influence of Psychotropic Drugs on Pituitary Hormone Secretion with Special Reference to Norepinephrine Reuptake Inhibition

  • G. Laakmann
  • A. Hinz
  • U. Voderholzer
  • R. Lehle
  • H. Neuhauser
  • M. Ortner
  • R. Meissner
Conference paper


In the last three decades, pharmacological treatment of psychiatric disorders using neuroleptic drugs, antidepressants, and tranquilizers has become common all over the world. The discovery that antidepressants inhibit the reuptake of norepinephrine (NE) and serotonin (5-HT) and that neuroleptics block the dopamine (DA) receptors led to the NE- and 5-HT-deficiency hypothesis of depression (Schildkraut 1965; Coppen 1967) and the dopamine hypothesis of schizophrenia (Carlsson 1978, 1988). Benzodiazepines are believed to potentiate the GABAergic system (Costa et al. 1978) by binding to specific receptors, called benzodiazepine receptors, which modify the sensitivity of GABA receptors (Squires and Braestrup 1977; Möhler and Okada 1978).


Growth Hormone Psychotropic Drug Growth Hormone Secretion Cortisol Secretion Growth Hormone Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • G. Laakmann
  • A. Hinz
  • U. Voderholzer
  • R. Lehle
  • H. Neuhauser
  • M. Ortner
  • R. Meissner
    • 1
  1. 1.Psychiatrische KlinikUniversität MünchenMünchen 2Germany

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