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Neuropsychopharmacology pp 286–293Cite as

Neuroendocrine Studies of α2-Adrenoceptor Function and the Mechanism of Action of Antidepressant Drugs

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Abstract

This review examines clinical studies addressing three questions that are central to an understanding of α2-adrenoceptor function in depression: (a) Are the α2-adrenoceptors that mediate the growth hormone (GH) response to clonidine abnormal in depression? (b) Is the functional status of these receptors modified by chronic antidepressant treatment in man? And (c) what is the net effect on noradrenergic neurotransmission in man of chronic treatment with antidepressant drugs?

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Author information

Authors and Affiliations

  1. Maudsley Hospital, De Crespigny Park, Denmark Hill, London, SE5 8AZ, UK

    S. Checkley

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  1. S. Checkley
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Editor information

Editors and Affiliations

  1. College of Medicine, University of California at Irvine, 92717, Irvine, CA, USA

    W. E. Bunney Jr. M. D. (Professor of Psychiatry) (Professor of Psychiatry)

  2. Psychiatrische Klinik und Poliklinik, Universität München, Nußbaumstraße 7, 8000, München 2, Germany

    Hanns Hippius  & Gregor Laakmann  & 

  3. Bezirkskrankenhaus Augsburg, Dr.-Mack-Straße 1, 8900, Augsburg, Germany

    Max Schmauss

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© 1990 Springer-Verlag Berlin Heidelberg

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Checkley, S. (1990). Neuroendocrine Studies of α2-Adrenoceptor Function and the Mechanism of Action of Antidepressant Drugs. In: Bunney, W.E., Hippius, H., Laakmann, G., Schmauss, M. (eds) Neuropsychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74034-3_28

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  • DOI: https://doi.org/10.1007/978-3-642-74034-3_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74036-7

  • Online ISBN: 978-3-642-74034-3

  • eBook Packages: Springer Book Archive

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