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Differential Effects and Receptors of Corticosteroids in the Brain: Implications for Psychopathophysiology

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Neuropsychopharmacology

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Abstract

Corticosteroids are of critical importance for homeostasis (Selye 1976; Munck et al. 1984; Levine et al. 1978; McEwen et al. 1986a). The steroids control basal activities in the animal throughout the circadian cycle and restore disturbances in homeostasis induced by stress (De Kloet et al. 1987; Dallman et al. 1987). Our research has indicated that these two modes of homeostatic control are regulated via distinct corticosteroid receptor systems that alter the genomic expression of the nerve cell (De Kloet et al. 1987; De Kloet and Reul 1987). Corticosteroid binding to these intracellular receptors in the limbic brain acts in concert with peptide and amine components of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. These interactions provide a complex linkage between adrenocortical function and neural processes involved in maintaining homeostasis and facilitating adaptation (De Wied and De Kloet 1987).

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Authors and Affiliations

  1. Rudolf Magnus Institute, Vondellaan 6, 3521 GD, Utrecht, The Netherlands

    E. R. De Kloet

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  1. E. R. De Kloet
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Editors and Affiliations

  1. College of Medicine, University of California at Irvine, 92717, Irvine, CA, USA

    W. E. Bunney Jr. M. D. (Professor of Psychiatry) (Professor of Psychiatry)

  2. Psychiatrische Klinik und Poliklinik, Universität München, Nußbaumstraße 7, 8000, München 2, Germany

    Hanns Hippius  & Gregor Laakmann  & 

  3. Bezirkskrankenhaus Augsburg, Dr.-Mack-Straße 1, 8900, Augsburg, Germany

    Max Schmauss

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© 1990 Springer-Verlag Berlin Heidelberg

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De Kloet, E.R. (1990). Differential Effects and Receptors of Corticosteroids in the Brain: Implications for Psychopathophysiology. In: Bunney, W.E., Hippius, H., Laakmann, G., Schmauss, M. (eds) Neuropsychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74034-3_23

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  • DOI: https://doi.org/10.1007/978-3-642-74034-3_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74036-7

  • Online ISBN: 978-3-642-74034-3

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