Platelet Monoamine Receptor Binding and Tricyclic Antidepressant Treatment
Human platelets possess a number of monoamine receptors which resemble biochemically their counterparts in the brain (Elliott 1984). In animal experimental studies there has been much interest in the adaptive changes in brain monoamine receptors that follow repeated administration of tricyclic antidepressants (TCAs). The time course of these receptor changes parallels that of the clinical effect of TCAs, and it has therefore been suggested that alterations in receptor sensitivity may be linked to the therapeutic action of antidepressant drugs (Green et al. 1986).
KeywordsClonidine Imipramine Amitriptyline Desipramine Clomipramine
Unable to display preview. Download preview PDF.
- Asberg M, Wagner A (1986) Biochemical effects of antidepressant treatment - studies of monoamine metabolities in cerebrospinal fluid and platelet [3H]imipramine binding. In: Antidepressants and receptor function. Ciba Foundation Symposium 123. Wiley, ChichesterGoogle Scholar
- Green AR, Heal DJ, Goodwin GM (1986) The effects of electroconvulsive therapy and antidepressant drugs on monoamine receptors in rodent brain - similarities and differences. In: Antidepressants and receptor function. Ciba Foundation Symposium 123. Wiley, ChichesterGoogle Scholar
- Katona CLE, Theodorou AE, Horton RW (1987) β-Adrenoceptors in depression. Psychiat Dev 2: 129–149Google Scholar
- LeysenJE, Gommeren W, Van Gompel P, Wynants J, Janssen P, Laduron PM (1985) Receptor binding properties in vitro and in vivo of ritanserin, a very potent and long- lasting serotonin-S2 antagonist. Mol Pharmacol 27: 600–611Google Scholar
- LeysenJE, Van Gompel P, Gommeren W, Woestenborghs R, Janssen PAJ (1986) Down- regulation of serotonin S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists ritanserin and setoperone. Psychopharmacology 88: 434–444Google Scholar
- Pimoule C, Briley MS, Gay C, Loo H, Sechter D, Zarifian E, Raisman R, Langer SZ (1983) 3[H]Rauwolscine binding in platelets from depressed patients and healthy volunteers. Psychopharmacology 79: 308–312Google Scholar
- Plenge P, Mellerup ET (1982) 3H-imipramine high affinity binding sites in rat brain: effect of imipramine and lithium. Psychopharmacology 77: 94–97Google Scholar