Platelet Monoamine Receptor Binding and Tricyclic Antidepressant Treatment
Human platelets possess a number of monoamine receptors which resemble biochemically their counterparts in the brain (Elliott 1984). In animal experimental studies there has been much interest in the adaptive changes in brain monoamine receptors that follow repeated administration of tricyclic antidepressants (TCAs). The time course of these receptor changes parallels that of the clinical effect of TCAs, and it has therefore been suggested that alterations in receptor sensitivity may be linked to the therapeutic action of antidepressant drugs (Green et al. 1986).
KeywordsDepressed Patient Rodent Brain Bioi Psychiatry Lysergic Acid Diethylamide Normal Male Subject
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