Platelet Monoamine Receptor Binding and Tricyclic Antidepressant Treatment

  • P. J. Cowen
  • L. E. Braddock
Conference paper


Human platelets possess a number of monoamine receptors which resemble biochemically their counterparts in the brain (Elliott 1984). In animal experimental studies there has been much interest in the adaptive changes in brain monoamine receptors that follow repeated administration of tricyclic antidepressants (TCAs). The time course of these receptor changes parallels that of the clinical effect of TCAs, and it has therefore been suggested that alterations in receptor sensitivity may be linked to the therapeutic action of antidepressant drugs (Green et al. 1986).


Depressed Patient Rodent Brain Bioi Psychiatry Lysergic Acid Diethylamide Normal Male Subject 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • P. J. Cowen
  • L. E. Braddock
    • 1
  1. 1.MRC Unit of Clinical Pharmacology and University Department of PsychiatryLittlemore HospitalOxfordUK

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