Abstract
T-lymphocyte proliferation is known to occur through two pathways, one involving the CD3 molecule and the other one the CD2 molecule (for review, see Alcover et al. 1987). PHA-P has been suggested to induce T cell proliferation via the CD2 pathway, since rise in calcium mobilization is blocked by anti-CD2 monoclonal antibodies (McAbs) (O’Flynn et al. 1985). Furthermore PHA-P does not stimulate the proliferation of cells lacking the CD2 molecule (O’Flynn et al. 1986).
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© 1988 Springer-Verlag Berlin Heidelberg
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Ferrone, S., De Felice, M., Turco, M.C., Corbo, L., Venuta, S. (1988). Effect of Anti-HLA Class I Monoclonal Antibodies on the Proliferation of T Cells Induced by PHA-P. Comparison with the Effect on T Cell Activation via the CD2 and CD3 Pathways. In: Ivanyi, P. (eds) MHC + X. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74026-8_16
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DOI: https://doi.org/10.1007/978-3-642-74026-8_16
Publisher Name: Springer, Berlin, Heidelberg
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