Immunization with Fibroblasts Expressing Human β2-Microglobulin Induces H-2 Specific Antibodies in Syngeneic Recipients
It is now generally accepted that the expression of some antigenic determinants of major histocompatibility complex (MHC) class I molecules results from a complex interaction between a heavy chain, encoded by highly polymorphic loci within the MHC, and the β 2-microglobulin (β 2-m) encoded by a rather monomorphic non-MHC locus. In an attempt to evaluate the structural consequences of the association of murine class I heavy chains with xenogeneic β 2-m, we investigated the antibody response of the mice injected with syngeneic fibroblasts expressing human β 2-m.
Unable to display preview. Download preview PDF.
- Čapková J, Hašek M, Kousalová M, Holáň V, Boubelík M (1983) Alloreactive cytotoxic anti-H-2 antibodies in sera of the syngeneically immunized C57BL/10ScSnPh, BALB/cJPh, and B10.A/SnPh mice. Folia Biol (Praha) 29: 200–212Google Scholar
- Kievits F, Opolski A, Boerenkamp WJ, Pla M, Ivanyi P (1987b) Monoclonal H-2 class I specific antibodies isolated after immunization of C57BL/6 mice with syngeneic Sendai-virus-coated cells. In: David CS (ed) H-2 antigens: genes, molecules, function. Plenum, New York, pp 669–680Google Scholar