MHC + X pp 72-76 | Cite as

Immunization with Fibroblasts Expressing Human β2-Microglobulin Induces H-2 Specific Antibodies in Syngeneic Recipients

  • Anna Rocca
  • Laurent Degos
  • Marika Pla
Conference paper


It is now generally accepted that the expression of some antigenic determinants of major histocompatibility complex (MHC) class I molecules results from a complex interaction between a heavy chain, encoded by highly polymorphic loci within the MHC, and the β 2-microglobulin (β 2-m) encoded by a rather monomorphic non-MHC locus. In an attempt to evaluate the structural consequences of the association of murine class I heavy chains with xenogeneic β 2-m, we investigated the antibody response of the mice injected with syngeneic fibroblasts expressing human β 2-m.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Anna Rocca
    • 1
  • Laurent Degos
    • 1
  • Marika Pla
    • 1
  1. 1.Laboratory of Mouse ImmunogeneticsU93 INSERM, Saint Louis HospitalParisFrance

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