Discovery and Chemistry of Naturally-Occurring Anticancer Agents

  • John M. Cassady
  • Ching-jer Chang
  • R. Graham Cooks
Conference paper

Abstract

Recent advances in the discovery of novel anticancer agents from higher plants are reported. These compounds are uncovered based on bioassay-directed fractionation and tandem MS analysis to detect analogs of significant lead compounds. The evolution and current status of the screening program of the U.S. National Cancer Institute is reviewed.

Structural work and chemistry is reported for active compounds from Annona densicoma, Cudrania cochinchinensis, Desfontainia spinosa, Pararistolochia flos-avis, Podocarpus species, Psorospermum febrifugum, and Spathelia sorbifolia. A number of these novel compounds exhibit sufficient activity to initiate studies of their mechanism of action and analog synthesis.

Keywords

Fractionation Folic Acid Alkaloid Epoxide Etoposide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • John M. Cassady
    • 1
  • Ching-jer Chang
    • 1
  • R. Graham Cooks
    • 2
  1. 1.Department of Medicinal Chemistry and Pharmacognosy School of Pharmacy and Pharmacal SciencesPurdue UniversityWest LafayetteUSA
  2. 2.Department of ChemistryPurdue UniversityWest LafayetteUSA

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