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Discovery and Chemistry of Naturally-Occurring Anticancer Agents

  • Conference paper
Natural Products Chemistry III

Abstract

Recent advances in the discovery of novel anticancer agents from higher plants are reported. These compounds are uncovered based on bioassay-directed fractionation and tandem MS analysis to detect analogs of significant lead compounds. The evolution and current status of the screening program of the U.S. National Cancer Institute is reviewed.

Structural work and chemistry is reported for active compounds from Annona densicoma, Cudrania cochinchinensis, Desfontainia spinosa, Pararistolochia flos-avis, Podocarpus species, Psorospermum febrifugum, and Spathelia sorbifolia. A number of these novel compounds exhibit sufficient activity to initiate studies of their mechanism of action and analog synthesis.

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Author information

Authors and Affiliations

  1. Department of Medicinal Chemistry and Pharmacognosy School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

    Dr. John M. Cassady & Dr. Ching-jer Chang

  2. Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA

    Dr. R. Graham Cooks

Authors
  1. Dr. John M. Cassady
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  2. Dr. Ching-jer Chang
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  3. Dr. R. Graham Cooks
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Editor information

Editors and Affiliations

  1. HEJ Research Institute of Chemistry, University of Karachi, Karachi-32, Pakistan

    Atta-ur-Rahman

  2. Department of Chemistry, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA

    Philip William Le Quesne

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© 1988 Springer-Verlag Berlin Heidelberg

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Cassady, J.M., Chang, Cj., Cooks, R.G. (1988). Discovery and Chemistry of Naturally-Occurring Anticancer Agents. In: Atta-ur-Rahman, Le Quesne, P.W. (eds) Natural Products Chemistry III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74017-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-74017-6_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74019-0

  • Online ISBN: 978-3-642-74017-6

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