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In Vitro Transformation of Murine Bone Marrow Cells with a v-raf/v-myc Retrovirus Yields Clonally Related Mature B Cells and Macrophages

  • M. Principato
  • S. P. Klinken
  • J. L. Cleveland
  • U. R. Rapp
  • K. L. Holmes
  • J. H. Pierce
  • H. C. MorseIII
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 141)

Abstract

Observations by various laboratories have indicated that lymphoid and myeloid cells derive from distinct precursors (Abramson, et al. 1977; Williams, et al. 1984) while other analyses have suggested that the differentiative programs of B cells and macrophages may be closely related. Some tumors (Davidson, et al. 1984; Neame et al. 1985; Strong, et al. 1985) and perinatal spleen and bone marrow cells were shown to coexpress putative B and myeloid lineage specific antigens (Holmes and Morse III, 1984), and tumors of B cell precursors have differentiated into cells with characteristics of mature macrophages (Boyd and Schrader, 1982; Holmes et al. 1986; Davidson et al. 1988). The demonstration of shared immunoglobulin heavy and light chain gene rearrangements in myeloid and B tumor cell lines have also suggested a close developmental relationship between these lineages (Holmes et al. 1986; Davidson et al. 1988; Bauer et al. 1986).

Keywords

Myeloid Lineage Light Chain Gene Murine Bone Marrow Cell Germline Configuration Kappa Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • M. Principato
    • 1
  • S. P. Klinken
    • 1
  • J. L. Cleveland
    • 3
  • U. R. Rapp
    • 3
  • K. L. Holmes
    • 1
  • J. H. Pierce
    • 2
  • H. C. MorseIII
    • 1
  1. 1.Laboratory of Immunopathology, NIAIDNCI, National Institutes of HealthBethesdaUSA
  2. 2.Laboratory of Cellular and Molecular BiologyNCI, National Institutes of HealthBethesdaUSA
  3. 3.Laboratory of Viral CarcinogenesisNCI, National Institutes of HealthBethesdaUSA

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