Abstract
Observations by various laboratories have indicated that lymphoid and myeloid cells derive from distinct precursors (Abramson, et al. 1977; Williams, et al. 1984) while other analyses have suggested that the differentiative programs of B cells and macrophages may be closely related. Some tumors (Davidson, et al. 1984; Neame et al. 1985; Strong, et al. 1985) and perinatal spleen and bone marrow cells were shown to coexpress putative B and myeloid lineage specific antigens (Holmes and Morse III, 1984), and tumors of B cell precursors have differentiated into cells with characteristics of mature macrophages (Boyd and Schrader, 1982; Holmes et al. 1986; Davidson et al. 1988). The demonstration of shared immunoglobulin heavy and light chain gene rearrangements in myeloid and B tumor cell lines have also suggested a close developmental relationship between these lineages (Holmes et al. 1986; Davidson et al. 1988; Bauer et al. 1986).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abramson S, Miller RG, Phillips RA (1977) The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid systems. J Exp Med 145: 1567–1579.
Alt F, Rosenberg N, et al. (1981) Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27: 381–390.
Bauer SR, Holmes KL, Morse HC III, Potter M (1986) clonal relationship of the lymphoblastic cell line P388 to the macrophage cell line P388D1 as evidenced by immunoglobulin gene rearrangements and expression of cell surface antigens. J Immunol 136: 4695–4699.
Blasi E, Mathieson BJ, Varesio L, et al. (1985) Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature 318: 667–670.
Blasi, E, Radzioch D, Durum S, Varesio L (1987) A murine macrophage cell line, immortalized by v-raf and v-myc oncogenes, exhibits normal macrophage functions. Eur J Immunol 17: 1491–1498.
Boyd AW, Schrader JW (1982) Derivation of macrophage like lines from the pre-B lymphoma ABLS 8.1 using 5-azacytidine. Nature 297: 691–693.
Cleveland JL, Jansen HW, Bister K et al. (1986) Interaction between raf and myc oncogenes in transformation in vivo and in vitro. J Cell Biochem 30: 195–218.
Davidson WF, Fredrickson TN, Rudikoff EK et al. (1984) A unique series of lymphomas related to the Ly-1+ lineage of B lymphocyte differentiation. J Immunol 133: 744–753.
Davidson WF, Pierce JH, Rudikoff S, Morse HC III (1988) Relationships between B cell and myeloid differentiation: Studies with a B lymphocyte progenitor line, HAFTL-1. In Press.
Duprey SP, Boettinger D (1985) Developmental regulation of c-myb in normal myeloid progenitor cells. Proc Natl Acad Sci USA 82: 6937–6941.
Holmes KL, Morse HC III (1984) Coexpression of Lyb-2 and Mac-1 by murine lymphomas and subpopulations of normal spleen and bone marrow cells. Curr Top Microbiol Immunol 113: 224–230.
Holmes KL, Pierce JH, Davidson WF, Morse HC III (1986) Murine hematopoietic cells with pre-B or pre-B/myeloid characteristics are generated by in vitro transformation with retroviruses containing fes, ras, abl and src oncogenes. J Exp Med 164: 443–457.
Lichtman AH, Reynolds DS, et al. (1986) Mature murine B lymphocytes immortalized by Kirsten sarcoma virus. Nature 324: 489–491.
Morse HC III, et al. (1986) Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice. Proc Natl Acad Sci USA 83: 6868–6872.
Neame PB, et al. (1985) Simultaneous or sequential expression of lymphoid and myeloid phenotypes in acute leukemia. Blood 65: 142–148.
Pierce JH, Aaronson SA (1982) BALB and Harvey murine sarcoma virus transformation of a novel lymphoid progenitor cell. J Exp Med 156: 873–879.
Pierce JH, Aaronson SA, Anderson SM (1984) Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus. Proc Natl Acad Sci USA 81: 2374–2376.
Radke K, Beug H, Kornfeld S, Graf T (1982) Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene Cell 31: 643–653.
Rapp UR, Cleveland JL, Fredrickson TN, et al. (1985) Rapid induction of hematopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus. J Virol 55: 23–33.
Rosenberg N, Baltimore D (1976) A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med 143: 1453–1463.
Strong RC, Korsmeyer SJ, et al. (1985) Human acute leukemia cell line with the T(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics. Blood 65: 21–31.
Subbarao B, Mosier DE (1983) Induction of B lymphocyte proliferation by monoclonal anti-Lyb2 antibody. J Immunol 130: 2033–2037.
Williams DA, Lemischka IR, Nathan DG, Mulligan RC (1984) Introduction of new genetic material into pluripotent hematopoietic stem cells of the mouse. Nature 310: 476–480.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Principato, M. et al. (1988). In Vitro Transformation of Murine Bone Marrow Cells with a v-raf/v-myc Retrovirus Yields Clonally Related Mature B Cells and Macrophages. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1988. Current Topics in Microbiology and Immunology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74006-0_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-74006-0_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74008-4
Online ISBN: 978-3-642-74006-0
eBook Packages: Springer Book Archive