In Vitro Transformation of Murine Bone Marrow Cells with a v-raf/v-myc Retrovirus Yields Clonally Related Mature B Cells and Macrophages
Observations by various laboratories have indicated that lymphoid and myeloid cells derive from distinct precursors (Abramson, et al. 1977; Williams, et al. 1984) while other analyses have suggested that the differentiative programs of B cells and macrophages may be closely related. Some tumors (Davidson, et al. 1984; Neame et al. 1985; Strong, et al. 1985) and perinatal spleen and bone marrow cells were shown to coexpress putative B and myeloid lineage specific antigens (Holmes and Morse III, 1984), and tumors of B cell precursors have differentiated into cells with characteristics of mature macrophages (Boyd and Schrader, 1982; Holmes et al. 1986; Davidson et al. 1988). The demonstration of shared immunoglobulin heavy and light chain gene rearrangements in myeloid and B tumor cell lines have also suggested a close developmental relationship between these lineages (Holmes et al. 1986; Davidson et al. 1988; Bauer et al. 1986).
KeywordsMyeloid Lineage Light Chain Gene Murine Bone Marrow Cell Germline Configuration Kappa Gene
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