Abstract
Abelson murine leukemia virus (Ab-MLV) is a replication defective retrovirus that carries the onc gene abl. The virus induces a rapid thymus-independent lymphoma in vivo under most conditions and transforms cells related to pre-B lymphocytes in vitro (reviewed in Rosenberg and Witte, 1988). The Abelson protein, the sole product of the virus, is a protein tyrosine kinase and expression of an enzymatically active Abelson protein is required for transformation (Rosenberg and Witte, 1988). Recent analyses of temperature sensitive (ts) mutants of Ab-MLV have indicated that expression of an active Abelson protein is also required for maintenance of NIH 3T3 cell transformation (Engelman and Rosenberg, 1987; Kipreos et al., 1987; Takemori et al., 1987). In addition, Abelson protein expression appears to play a role in maintaining the relatively undifferentiated state of some Ab-MLV-transformed lymphoid cells (Takemori et al., 1987).
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© 1988 Springer-Verlag Berlin · Heidelberg
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Engelman, A., Rosenberg, N. (1988). The Abelson Protein Is Required for Initiation and Maintenance for Transformation in Murine Pre-B Cells. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1988. Current Topics in Microbiology and Immunology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74006-0_41
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DOI: https://doi.org/10.1007/978-3-642-74006-0_41
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