Abstract
A role for the c-myc proto-oncogene in growth factor signal transduction first came from experiments showing that the gene was inducible by treating quiescent T cells and fibroblasts with experimental mitogens or growth factors (Kelly et al., 1983). Subsequently, subtractive cDNA cloning from PDGF-treated fibroblast cells identified c-myc as an early Gl or competence gene in these cells (Cochran et al., 1983). Significance for this induction was established from studies demonstrating that introduction of constitutively expressed source of exogenous c-myc or microinjection of purified c-myc protein relieved the requirements for PDGF in the transition from GO into Gl (Armelin et al., 1984; Kaczmarek et al., 1985).
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References
Armelin HA, Armelin MCS, Kelly, K, Stewart T, Leder P, Cochran BH, Stiles CD (1984) Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature (London) 310: 655–660
Bentley D, Groudine M (1986) A block tom elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells. Nature (London) 321: 702–706
Cochran BH, Reffel AC, Stiles CD (1983) Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell 33: 939–683
Dean M, Cleveland JL, Rapp UR, Ihle JN (1987) Role of myc in the abrogation of IL-3 dependence of myeloid FDC-pl cells. Oncogene Res. 1: 279–296
Eick D, Bornkam G (1986) Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression. Nucleic Acids Res. 14: 8331–8346
Kaczmarek L, Hyland JK, Watt R, Rosenbert M, Baserga R (1985) Microinjected c-myc as a competence factor. Science 228: 1313–1315
Kelly K, Cochran BH, Stiles CD, Leder P (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35: 603–610
Mathey-Prevot B, Nabel G, Palacios R, Baltimore D (1986) Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line. Mol. Cell. Biol. 6: 4133–4135
Mechti N, Piechaczyk M, Blanchard J-M, Marty L, Jeanteur P, LeBleu B (1986) Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells. Nucleic Acids Res. 14: 9653–9666
Pelicci PG, Knowles DM, Magrath I, Dalla-Favera R (1986) Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc. Natl. Acad. Sci. U.S.A. 83: 2984–2988
Pierce JH, DeFiore PP, Aaronson SA, Potter M, Pumphrey J, Scott A, Ihle JN (1985) Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a non-autocrine mechanism. Cell 41: 685–693
Pierce JH, Ruggiero M, Fleming TP, DeFiore PP, Greenberger JS, Varticovski L, Schlessinger J, Rovera G, Aaronson SA (1988) Signal transduction through the EGF receptor transfected in IL-3 dependent hematopoietic cells. Science 239: 628–631
Rapp UR, Cleveland JL, Brightman K, Scott A, Ihle JN (1985) Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes. Nature (London) 317: 434–438
Wheeler EF, Askew D, May S, Ihle JN, Scherr CJ (1987) The v-fms oncogene induces factor independent growth and transformation of the IL-3 dependent cell line, FDC-P1. Mol. Cell. Biol. 7: 1673–1680
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Cleveland, J.L., Dean, M., Wang, J.Y., Hedge, AM., Ihle, J.N., Rapp, U.R. (1988). Abrogation of IL-3 Dependence of Myeloid FDC-P1 Cells by Tyrosine Kinase Oncogenes Is Associated with Induction of c-myc . In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1988. Current Topics in Microbiology and Immunology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74006-0_40
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DOI: https://doi.org/10.1007/978-3-642-74006-0_40
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