Abstract
Previous studies of lymphomas and normal cells suggested that the putatively macrophage-specific antigen, Mac-1 may be expressed by precursors of the B cell lineage. This possibility was tested by analyzing the potential of sorted Mac-1+ cells from adult bone marrow (BM) to reconstitute CB.17-scid mice or sublethally irradiated B6-Ly-5.2 congenic mice. The results show that Mac-1+ BM cells include precursors to both T and B lymphocytes as determined by FACS analysis of spleen, bone marrow and thymus from mice inoculated with Mac-1+ cells. Three color FACS analysis showed that thymocyte subpopulations from B6-congenic mice inoculated with Mac-1+ cells were composed largely of donor cells, indicating that the donor-derived peripheral T cells had undergone normal thymic processing.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Holmes, K.L., Lee, J.S., Morse, H.C. (1988). Mac-1+ Bone Marrow Cells Include Precursors of B Cells and T Cells. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1988. Current Topics in Microbiology and Immunology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74006-0_4
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DOI: https://doi.org/10.1007/978-3-642-74006-0_4
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