Abstract
Expression of the c-myc proto-oncogene is regulated by mitogens in a number of cell types, including fibroblasts and lymphoid cells. In growth arrested fibroblasts, serum, epidermal growth factor, or platelet derived growth factor are all capable of inducing c-myc mRNA (Campisi et al., 1984; Kelly et al.,1983). The mechanism of this induction appears to require either protein kinase C- or protein kinase A-dependent events (Ran et al., 1986). We have begun to examine these events in greater detail by studying fibroblasts showing de-regulated c-myc expression and myeloid cells containing exogenously introduced c-myc constructs.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Dean, M. et al. (1988). Deregulation of the c-myc and N-myc Genes in Transformed Cells. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1988. Current Topics in Microbiology and Immunology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74006-0_29
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DOI: https://doi.org/10.1007/978-3-642-74006-0_29
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