Advertisement

Elevated Levels of the c-myc Protein in Bloom’s Syndrome and Induction of c-myc by DNA Strand Breakage

  • N. F. Sullivan
  • A. E. Willis
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 141)

Abstract

We demonstrate elevated levels of the c-myc protein in lymphoblastoid cell lines derived from Bloom’s syndrome patients and, furthermore, show that treatment of normal lymphocytes with DNA damaging agents results in induction of c-myc protein. We present a model whereby increased DNA strand breakage in Bloom’s syndrome, as a consequence of the reduced activity of DNA ligase I, results in the constitutive induction of c-myc. Increased c-myc protein may thus contribute towards the predisposition to cancer observed in Bloom’s syndrome.

Keywords

Burkitts Lymphoma Sister Chromatid Exchange Ataxia Telangiectasia Imperial Cancer Research Fund Conjugate Goat Anti Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arrand JE, Willis AE, Goldsmith I and Lindahl T (1986) J. Biol. Chem. 261, 9097–9082.Google Scholar
  2. Cerni C, Mougneau E and Curzin F (1987) Exp. Cell Res., 168, 439–446.PubMedCrossRefGoogle Scholar
  3. Chaganti RSK, Schonberg S and German J (1974) Proc. Natl. Acad. Sci. U.S.A., 71, 4505–4512.CrossRefGoogle Scholar
  4. Evans HJ (1982) Chap. 7 in “Sister Chromatid Exchange” 184–214, ed. Sheldon Wolff, Wiley and Sons.Google Scholar
  5. German J, Bloom D and Passarge E(1984) Clin. Genet, 25, 166–174.PubMedCrossRefGoogle Scholar
  6. Henderson E and Ribeckey R(1980) Chem. Biol. Interactions, 33, 63–81.CrossRefGoogle Scholar
  7. Krepinski AB, Heddle JA and German J (1979) Hum. Genet, 50, 151–156.CrossRefGoogle Scholar
  8. Lindahl T (1982) Ann. Rev. Biochem., 51, 61–87.PubMedCrossRefGoogle Scholar
  9. Moore JP, Hancock DC, Littlewood TD and Evan GI (1988) Oncogene Res., 2, 65–80.Google Scholar
  10. Watt RA, Shatzman A and Rosenberg R (1985) Mol. Cell. Biol., 5, 448–456.PubMedGoogle Scholar
  11. Weksberg R, Smith C, Anson-Cartwright L and Maloney K. Am. J. Hum. Genet., in press.Google Scholar
  12. Willis AE and Lindahl T (1987) Nature, 325, 355–357.PubMedCrossRefGoogle Scholar
  13. Willis AE, Weksberg R, Tomlinson S. and Lindahl T (1987) Proc. Natl. Acad. Sci. U.S.A., 84, 8016–8020.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • N. F. Sullivan
    • 1
  • A. E. Willis
    • 1
  1. 1.Imperial Cancer Research FundClare Hall LaboratoriesHerts.UK

Personalised recommendations