Elevated Levels of the c-myc Protein in Bloom’s Syndrome and Induction of c-myc by DNA Strand Breakage

  • N. F. Sullivan
  • A. E. Willis
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 141)


We demonstrate elevated levels of the c-myc protein in lymphoblastoid cell lines derived from Bloom’s syndrome patients and, furthermore, show that treatment of normal lymphocytes with DNA damaging agents results in induction of c-myc protein. We present a model whereby increased DNA strand breakage in Bloom’s syndrome, as a consequence of the reduced activity of DNA ligase I, results in the constitutive induction of c-myc. Increased c-myc protein may thus contribute towards the predisposition to cancer observed in Bloom’s syndrome.


Burkitts Lymphoma Sister Chromatid Exchange Ataxia Telangiectasia Imperial Cancer Research Fund Conjugate Goat Anti Mouse 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • N. F. Sullivan
    • 1
  • A. E. Willis
    • 1
  1. 1.Imperial Cancer Research FundClare Hall LaboratoriesHerts.UK

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