Elevated Levels of the c-myc Protein in Bloom’s Syndrome and Induction of c-myc by DNA Strand Breakage
We demonstrate elevated levels of the c-myc protein in lymphoblastoid cell lines derived from Bloom’s syndrome patients and, furthermore, show that treatment of normal lymphocytes with DNA damaging agents results in induction of c-myc protein. We present a model whereby increased DNA strand breakage in Bloom’s syndrome, as a consequence of the reduced activity of DNA ligase I, results in the constitutive induction of c-myc. Increased c-myc protein may thus contribute towards the predisposition to cancer observed in Bloom’s syndrome.
KeywordsLymphoma Recombination Mitomycin Ligase Iodoacetamide
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