Significance of Chromosome 8 Breakpoint Location in Burkitt’s Lymphoma: Correlation with Geographical Origin and Association with Epstein-Barr Virus
Burkitt’s lymphoma (BL) is a B cell neoplasm, which occurs throughout the world, predominantly in children and young adults [Magrath 1983]. Its relatively high incidence in equatorial Africa has led to the African form of the disease being designated as “endemic” (eBL), while cases outside equatorial Africa are referred to as “sporadic” (sBL) Burkitt’s lymphoma. A number of differences between eBL and sBL have been described [Magrath 1986] and are summarized in table 1.
Unable to display preview. Download preview PDF.
- Magrath IT: Burkitt’s lymphoma: clinical aspects and treatment. In Wolander DW (ed.) Diseases of the lymphatic system. 1983 Springer Verlag, p.103.Google Scholar
- Magrath IT: Burkitt’s lymphoma as a human tumor model: New concepts in etiology and pathogenesis. In Pediatric Hematology Oncology Reviews. Pochedly C (ed.) Praeger, Westport, 1986.pp 1–51Google Scholar