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Significance of Chromosome 8 Breakpoint Location in Burkitt’s Lymphoma: Correlation with Geographical Origin and Association with Epstein-Barr Virus

  • F. Barriga
  • J. Kiwanuka
  • M. Alvarez-Mon
  • B. Shiramizu
  • B. Huber
  • P. Levine
  • I. Magrath
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 141)

Abstract

Burkitt’s lymphoma (BL) is a B cell neoplasm, which occurs throughout the world, predominantly in children and young adults [Magrath 1983]. Its relatively high incidence in equatorial Africa has led to the African form of the disease being designated as “endemic” (eBL), while cases outside equatorial Africa are referred to as “sporadic” (sBL) Burkitt’s lymphoma. A number of differences between eBL and sBL have been described [Magrath 1986] and are summarized in table 1.

Keywords

Distant Breakpoint Negative Regulatory Element Cryptic Promotor Breakpoint Location Exon Probe 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • F. Barriga
    • 1
    • 2
  • J. Kiwanuka
    • 1
    • 2
  • M. Alvarez-Mon
    • 1
    • 2
  • B. Shiramizu
    • 1
    • 2
  • B. Huber
    • 1
    • 2
  • P. Levine
    • 1
    • 2
  • I. Magrath
    • 1
    • 2
  1. 1.Pediatric and Epidemiology BranchesNational Cancer InstituteBethesdaUSA
  2. 2.Burroughs WellcomeResearch TriangleUSA

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