Advertisement

Molecular Analysis of an AIDS-Associated Burkitt’s Lymphoma: Near-Identity with Endemic Cases

  • F. G. Haluska
  • G. Russo
  • M. Andreeff
  • C. M. Croce
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 141)

Abstract

The most completely studied B-cell malignancy is Burkitt’s lymphoma, an understanding of which has been facilitated by a cytogenetic and molecular analyses of the chromosome translocations which are consistently exhibited by these tumors (reviewed in Haluska et al., 1987a). The translocations seen in Burkitt’s lymphomas abnormally juxtapose one of the immunoglobulin loci with the c-myc proto-oncogene. A small proportion of these chromosome translocations involve the light chain loci. Thus, the t(2;8)(p11;q24) translocation approximates the kchain genes on chromosome 2 with the c-myc gene on chromosome 8; similarly, the t(8;22)(q24;q11) translocation juxtaposes the c-myc gene and the λ chain genes. But in over 80% of cases, the relevant translocation is the t(8;14)(q24;q32). In this instance, the c-myc gene is translocated into the immunoglobulin heavy chain region. Consequently, normal regulation of c-myc expression is abrogated, and malignancy ensues.

Keywords

Acquire Immune Deficiency Syndrome Translocation Breakpoint Light Chain Locus Germ Line Clone Amplification Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Croce CM, Thierfelder W, Erikson J, Nishikura K, Finan J, Lenoir G, Nowell PC (1983) Transcriptional activation of an prearranged and untranslocated c-myc oncogene by translocation of a C X locus in Burkitt lymphoma cells. Proc Natl Acad Sei USA 80: 6922–6926CrossRefGoogle Scholar
  2. Erikson J, Nishikura K, ar-Rushdi A, Finan J, Emanuel B, Lenoir G, Nowell PC, Croce CM (1983) Translocation of an immunoglobulin k locus to a region 3’ of an unrearranged c-myc oncogene enhances c-myc transcription. Proc Natl Acad Sci USA 80: 7581–7585PubMedCrossRefGoogle Scholar
  3. Haluska FG, Finver SN, Tsujimoto Y, Croce CM (1986) The t(8;14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V-D-J joining. Nature 324: 158–161PubMedCrossRefGoogle Scholar
  4. Haluska FG, Tsujimoto Y, Croce CM (1987a) Oncogene activation by chromosome translocation in human malignancy. Ann Rev Genet 21: 321–345PubMedCrossRefGoogle Scholar
  5. Haluska FG, Tsujimoto Y, Croce CM (1987b) The t(8;14) translocation of the Daudi endemic Burkitt’s lymphoma occurred during immunoglobulin gene rearrangement and involved the Du region. Proc Natl Acad Sci USA 84: 6835–6839PubMedCrossRefGoogle Scholar
  6. Haluska FG, Tsujimoto Y, Croce CM (1987c) Mechanisms of chromosome translocation in B- and T-cell neoplasia. Trends Genet 3: 11–15CrossRefGoogle Scholar
  7. Klein G, Klein E (1985) Evolution of tumors and the impact of molecular oncology. Nature 315: 190–195PubMedCrossRefGoogle Scholar
  8. Pelicci P-G, Knowles DM II, Arlin ZA, Wieczorek R, Luciw P, Dina D, Basilico C, Dalla-Favera R (1986) Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders: implications for lymphomagenesis. J Exp Med 164: 2049–2076PubMedCrossRefGoogle Scholar
  9. Pelicci P-G, Knowles DM II, Magrath I, Dalla-Favera R (1986) Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc Natl Acad Sci USA 83: 2984–2988PubMedCrossRefGoogle Scholar
  10. Tsujimoto Y, Cossman J, Jaffe E, Croce CM (1985) Involvement of the bcl-2 gene in human follicular lymphoma. Science 228: 1440–1443PubMedCrossRefGoogle Scholar
  11. Ziegler JL, Miner RC, Rosenbaum E, Lennette ET, Shillitoe E, Casavant C, Drew WL, Mintz L, Gershow J, Greenspan J, Beckstead J, Yamamoto K (1982) Outbreak of Burkitt’s-like lymphoma in homosexual men. Lancet ii: 631–633CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • F. G. Haluska
    • 1
  • G. Russo
    • 1
  • M. Andreeff
    • 2
  • C. M. Croce
    • 1
  1. 1.The Wistar InstitutePhiladelphiaUSA
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

Personalised recommendations