The Laboratory Mouse - a Potential Experimental Model for Studies on Age-related Bone Loss
In humans, peak adult bone mass is reached at about age 35 and a few years later a gradual universal reduction of bone mass begins. This disorder which is characterized by a reduced amount of bony tissue per unit volume of bone is termed osteoporosis and is a major cause of fractures in postmenopausal women and in the elderly. Recent studies in our laboratory, using C57BL/6 female mice indicated that various skeletal tissues are profoundly affected during old age (1). It was the purpose of the present study to further elucidate the effect of age upon a long bone in female CW-1 mice and the effect of physical exercise upon bone loss in the aging animal.
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- 1.Silbermann, M., Weiss, A., Reznick, A., Eilam, Y., Szydel, N., Gershon, D. (1987): Age-related trend for osteopenia in femurs of female C57BL/6 mice. Compr. Gerontol. 1:45–51Google Scholar