Osteonectin Expression in Odontogenous and Non-odontogenous Tumors and Tumor-like Lesions of the Skull and Jaw Bones
The organic matrix of osseous and odontogenic tissues is formed mainly by collagen type I. In addition there is a considerable bulk of noncollagenous proteins (Prince et al. 1987) in bone among which osteonectin represents the greatest amount. This protein, first isolated by Termine et al. (1981) has a molecular weight of 29 kD and possibly is involved in the mineralization process of collagenous fibrils in bone (Romberg et al. 1985). Recently osteonectin could be demonstrated in bone tumors and normal bone and has been considered as a marker for bone tumor cells (Schulz et al. 1985; Jundt et al. 1987). The aim of the present study was to examine the expression of osteonectin in odontogenous and non-odontogenous tumors and tumor-like lesions of the jaw bones in order to get further insight into the histogenesis of the bone and odontogenic structure forming process.
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