Anti-Edema Effect of Protease Inhibitors
The activity of beta-glucuronidase (BGL), a lysosomal enzyme, increases in edematous brain (Bingham et al. 1971). Steroids are considered to be effective against the vasogenic type of brain edema. In this communication, I report that experimental brain edema is prevented by the administration of protease inhibitors (urinastatin or aprotinin) and that the increase in BGL activity of the edematous brain is also reduced by protease inhibitors.
KeywordsSucrose Phenol Propylene Neurol Aprotinin
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- Baethmann A, Oettinger W, Rothenfusser W, Kempski O, Unterberg A, Geiger R (1980) Brain edema factors: current state with particular reference to plasma constituents and glutamate. In: Cerevos-Navarro J and Ferszt R (eds) Advances in neurology, vol 28: Brain edema. Raven Press, New York, pp 171–195Google Scholar
- Egami T (1970) The effect of proteolytic enzyme inhibitor on experimental brain swelling. Bull Yamaguchi Med School 17:207–238Google Scholar
- Elliot KAC, Jasper H (1949) Measurement of experimentally induced brain swelling and shrinkage. Am J Physiol 157: 122–129Google Scholar