Anti-Edema Effect of Protease Inhibitors

  • M. Yamaguchi
Conference paper


The activity of beta-glucuronidase (BGL), a lysosomal enzyme, increases in edematous brain (Bingham et al. 1971). Steroids are considered to be effective against the vasogenic type of brain edema. In this communication, I report that experimental brain edema is prevented by the administration of protease inhibitors (urinastatin or aprotinin) and that the increase in BGL activity of the edematous brain is also reduced by protease inhibitors.


Brain Edema Evans Blue Edema Factor Brain Edema Formation Vasogenic Brain Edema 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. Yamaguchi
    • 1
  1. 1.School of Allied Medical SciencesKobe UniversitySuma, KobeJapan

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