The Role of Oxidative Reactions in Decompression Ischemic Edema

  • A. Schettini
  • B. W. Gibbs
  • E. K. Walsh
Conference paper

Abstract

Rapid decompression of an expanded extradural balloon is followed by intracranial hypertension, cerebral edema, and not uncommonly fatal outcome. Although the exact mechanism remains conjectural, it has been documented that this decompression is accompanied by cortical hypoperfusion, vascular injury of cortical microvasculature, and cerebral edema (Busto 1984, Yamaguchi 1976)

Keywords

Hydrated Ischemia Hydroxyl Benzene Superoxide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Betz AL (1985) Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries. J Neurochem 44:574–579PubMedCrossRefGoogle Scholar
  2. Busto R, Yoshida S, Ginsberg MD, Alonso O, Smith DW, Goldberg WJ (1984) Regional blood flow in compression-induced brain edema in rats: Effect of dietary Vitamin E. Ann Neurol 15:441–448PubMedCrossRefGoogle Scholar
  3. Chan PH, Longar S, Fishman A (1985) Oxygen free radicals. Potential edema mediators. In: Inaba Y, Klatzo I, Spatz M (eds) Brain edema. Springer, Berlin Heidelberg New York Tokyo, pp 317–323CrossRefGoogle Scholar
  4. Czernicki Z, Kozniewska E (1977) Disturbances in the blood brain barrier and cerebral blood flow after rapid brain decompression in the cat. Acta Neurochir (Wien) 36:171–187CrossRefGoogle Scholar
  5. Davis RJ, Bulkley GB, Traystman RJ (1987) Role of oxygen free radicals in focal brain ischemia. Fed Proc 46:2816Google Scholar
  6. Halliwell B, Gutteridge JM (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219:1–14PubMedGoogle Scholar
  7. Kontos HA, Wei EP (1986) Superoxide production in experimental brain injury. J Neurosurg 64:803–807PubMedCrossRefGoogle Scholar
  8. Marmarou A, Tanaka K, Shulman K (1982) An improved gravimetric measure of cerebral edema. J Neurosurg 56:246–253PubMedCrossRefGoogle Scholar
  9. Schettini A, Walsh EK, Beck J, Salton RA (1986) Brain elastic behavior and CSF dynamics in cold induced edema. In: Miller JD, Teasdale GM, Rowan JO, Gailbraith SL, Mendelow AD (eds) Intracranial pressure VI. Springer, Berlin Heidelberg New York Tokyo, pp 68–73Google Scholar
  10. Thompson RK, Saleman M (1988) Dynamic axial brain stem distortion as a mechanism in the production of brain stem hemorrhages: role of the carotid arteries. Neurosurgery 22:629–632PubMedCrossRefGoogle Scholar
  11. Walsh EK, Schettini A (1984) Calculation of brain elastic parameters in vivo. Am J Physiol 247:R693–R700PubMedGoogle Scholar
  12. Walsh EK, Schettini A, Beck J, Salton RA (1986) Brain elastic behavior and CSF dynamics during progressive epidural balloon expansion. In: Miller JD, Teasdale GM, Rowan JO, Gailbraith SL, Mendelow AD (eds) Intracranial pressure VI. Springer, Berlin Heidelberg New York Tokyo, pp 62–67Google Scholar
  13. Yamaguchi M, Shirakata S, Yamasaki S, Matsumoto S (1976) Ischemic brain edema and compression brain edema. Water content, blood-brain barrier and circulation. Stroke 7:77–83CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. Schettini
    • 1
    • 2
  • B. W. Gibbs
    • 1
    • 2
  • E. K. Walsh
    • 1
    • 2
  1. 1.Research Service (151)McGuire Veterans Administration Medical CenterRichmondUSA
  2. 2.College of EngineeringUniversity of FloridaGainesvilleUSA

Personalised recommendations