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Recovery Rates of Evoked Potentials, Intracellular pH and Bicarbonate Ion After ICP-Induced Ischemia

  • M. K. Nishijima
  • R. C. Koehler
  • S. M. Eleff
  • P. D. Hurn
  • S. Norris
  • W. E. Jacobus
  • R. J. Traystman
Conference paper

Abstract

Intracellular acidosis is thought to be one of the major factors that contribute to cerebral injury during ischemia. Upon reperfusion, intracellular pH (pHi) eventually recovers, but normalization is not immediate (Smith et al. 1986). The speed of recovery of pHi is probably slower than the speed at which pHi drops during the onset of ischemia because regeneration of intracellular buffers requires a finite time. We postulated that the rate of recovery of pHi may be a marker of cerebral injury because it may reflect the brain’s ability to restore ionic gradients necessary for conductive function. In addition, persistent acidosis during reperfusion may further augment injury.

Keywords

Evoke Potential Somatosensory Evoke Potential Cerebral Injury Intracellular Acidosis Intracellular Buffer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. Smith M-L, von Hanwehr R, Siesjö BK (1986) Changes in extra- and intracellular pH in the brain during and following ischemia in hyperglycemic and in moderately hypoglycemic rats. J Cereb Blood Flow Metab 6: 574–583PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. K. Nishijima
    • 1
  • R. C. Koehler
    • 1
  • S. M. Eleff
    • 1
  • P. D. Hurn
    • 1
  • S. Norris
    • 1
  • W. E. Jacobus
    • 1
  • R. J. Traystman
    • 1
  1. 1.Department of Anesthesiology/Critical Care MedicineThe Johns Hopkins Medical InstitutionsBaltimoreUSA

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