The Effect of Cerebral Edema on Reperfusion Blood Flow Deficit in Ischemic Animals
Transient cerebral ischemia has been shown to result in a series of interrelated pathologic changes in brain physiology with the resumption of blood flow. After a significant period of ischemia, the brain shows ischemic cerebral edema, increased intracranial pressure, and reperfusion decreases in regional cerebral blood flow. Deficits in neuroelectrical functioning and the abnormal generation of metabolic by-products have also been noted. The exact relationship of these processes with one another is not completely understood. The specific effect of the generation of regional cerebral edema on cerebral blood flow is not known. Edema may cause constriction of arteriolar diameter resulting in decreased blood flow, or the two processes may be related only in that both are caused by some other effect of the initial ischemic insult.
KeywordsIschemia Benzene Platinum Mannitol Ketamine
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