Allopurinol and Dimethylthiourea Limit Infarct Size in Partial Ischemia
Toxic oxygen metabolites such as superoxide and hydrogen peroxide are produced as a normal part of cellular metabolism. These compounds, as well as their breakdown products, may act to injury the macromolecular components of the cellular cytoplasm and membrane. Under normal circumstances, adequate intracellular defense mechanisms are present to neutralize these toxic species. However, in settings of tissue ischemia, these buffers may be used up, allowing direct attack of free radicals on cellular constituents. This interaction can result in cell injury and death.
KeywordsHydrogen Peroxide Ischemia Hydroxyl Superoxide Catalase
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