Biochemical and Biophysical Parameters Under Thiopental Infusion in Severe Head Injured Patients

  • F. Della Corte
  • P. Carducci
  • A. Clemente
  • M. Sciarra
  • R. S. Brada
  • C. Anile
  • R. Proietti
Conference paper

Abstract

The rationale for the use of long term high dose barbiturates depends still on two debated considerations:

a) their efficacy in long term control of intracranial hypertension (IH) refractory to conventional treatment (Rockoff et al. 1979); b) their role in improvement of prognosis through control of ICP (Nordby et al. 1984).

The aim of the study was to evaluate the effects of continuous thiopental (TPS) infusion on intracranial biophysical and biochemical parameters in severe head injured patients.

Keywords

Catheter HPLC Lactate Neurol Diene 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rockoff MA et al. (1979) High dose barbiturate therapy in humans: A clinical review of 60 patients. Ann Neurol 6: 194–199PubMedCrossRefGoogle Scholar
  2. Nordby HK et al. (1984) The effect of high dose barbiturate after severe head injury — a controlled clinical trial. Acta Neurochir (Wien) 72: 157–166CrossRefGoogle Scholar
  3. DeSalles AA, Kontos HA (1986) Prognostic significance of ventricular CSF lactic acidosis in severe head injuries. J Neurosurg 65: 615–624PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. Della Corte
    • 1
  • P. Carducci
    • 1
  • A. Clemente
    • 1
  • M. Sciarra
    • 1
  • R. S. Brada
    • 1
  • C. Anile
    • 1
  • R. Proietti
    • 1
  1. 1.Istituto Di Anestesiologia E Rianimazione, Istituto Di NeuochirurgiaUniversitá Cattolica S. Cuore, Largo ARomeItaly

Personalised recommendations