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Effect of Hemorrhagic Hypotension on CBF and ICP After Brain Missile Wounding in Anesthetized Paralyzed Cats

  • D. Torbati
  • B. J. Farrell
  • J. F. Davidson
  • M. E. Carey
Conference paper

Abstract

The intracranial pressure (ICP) may increase following brain missile wounding (BMW), leading to a corresponding decrease in cerebral perfusion pressure (CPP). Extreme reductions in CPP (i.e. <40 mm Hg), can affect both CBF auto-regulation (Zwetnow 1968) and reduce brain energy metabolism (Zwetnow 1970). BMW-induced pathology may also impair CBF autoregulation, while hemorrhagic hypotension (associated with multiple wounds) could further aggravate the breakdown of CBF autoregulation. In the present study alterations in ICP and CPP in relation to CBF autoregulation by means of hemorrhagic hypotension were investigated in unwounded and brain wounded anesthetized paralyzed cats.

Keywords

Time Zero Cerebral Perfusion Pressure Severe Metabolic Acidosis Shed Blood Extreme Reduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Carey ME, Sarna GS, Farrell JB, Happel LT (1988) Experimental missile wound to the brain. A new model in the anesthetized cat. Submitted for publicationGoogle Scholar
  2. Zwetnow N (1968) CBF autoregulation to blood pressure and intracranial pressure variations. Scand J Lab Clin Invest [Suppl] 102V: AGoogle Scholar
  3. Zwetnow N (1970) The influence of an increased ICP on the lactate, pyruvate, bicarbonate, phosphocreatine, ATP, ADP and AMP concentrations of the cerebral cortex of dog. Acta Physiol Scand 79: 158–166PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • D. Torbati
    • 1
  • B. J. Farrell
    • 1
  • J. F. Davidson
    • 1
  • M. E. Carey
    • 1
  1. 1.Department of NeurosurgeryLouisiana State University Medical CenterNew OrleansUSA

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