Effect of Hemorrhagic Hypotension on CBF and ICP After Brain Missile Wounding in Anesthetized Paralyzed Cats
The intracranial pressure (ICP) may increase following brain missile wounding (BMW), leading to a corresponding decrease in cerebral perfusion pressure (CPP). Extreme reductions in CPP (i.e. <40 mm Hg), can affect both CBF auto-regulation (Zwetnow 1968) and reduce brain energy metabolism (Zwetnow 1970). BMW-induced pathology may also impair CBF autoregulation, while hemorrhagic hypotension (associated with multiple wounds) could further aggravate the breakdown of CBF autoregulation. In the present study alterations in ICP and CPP in relation to CBF autoregulation by means of hemorrhagic hypotension were investigated in unwounded and brain wounded anesthetized paralyzed cats.
KeywordsIschemia Lactate Pyruvate Bicarbonate Pentobarbital
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- Carey ME, Sarna GS, Farrell JB, Happel LT (1988) Experimental missile wound to the brain. A new model in the anesthetized cat. Submitted for publicationGoogle Scholar
- Zwetnow N (1968) CBF autoregulation to blood pressure and intracranial pressure variations. Scand J Lab Clin Invest [Suppl] 102V: AGoogle Scholar