Effects of Antihypertensive Drugs on Intracranial Hypertension
Systemic hypertension is frequently observed in patients with cerebrovascular disease, such as hypertensive intracerebral hemorrhage and subarachnoid hemorrhage, which is often associated with intracranial hypertension. Continuing systemic hypertension might not only augment the risk of rebleeding but also might increase the blood flow and blood volume, resulting in more marked increase in intracranial hypertension. On the other hand, it has been reported that some antihypertensive drugs can produce an increase in intracranial pressure (ICP). In this study, we examined the effects of some antihypertensive agents that are commonly used in neurosurgical practice, on systemic arterial blood pressure (ABP), ICP and cerebral perfusion pressure (CPP) in patients with both increased ICP and systemic hypertension, and attempted to clarify the risks and benefits of these agents when used in patients with raised ICP
KeywordsCatheter Depression Nifedipine Furosemide Pentobarbital
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