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Effects of Antihypertensive Drugs on Intracranial Hypertension

  • S. Hirose
  • Y. Handa
  • M. Hayashi
  • N. Shirasaki
  • H. Kobayashi
  • H. Kawano
Conference paper

Abstract

Systemic hypertension is frequently observed in patients with cerebrovascular disease, such as hypertensive intracerebral hemorrhage and subarachnoid hemorrhage, which is often associated with intracranial hypertension. Continuing systemic hypertension might not only augment the risk of rebleeding but also might increase the blood flow and blood volume, resulting in more marked increase in intracranial hypertension. On the other hand, it has been reported that some antihypertensive drugs can produce an increase in intracranial pressure (ICP). In this study, we examined the effects of some antihypertensive agents that are commonly used in neurosurgical practice, on systemic arterial blood pressure (ABP), ICP and cerebral perfusion pressure (CPP) in patients with both increased ICP and systemic hypertension, and attempted to clarify the risks and benefits of these agents when used in patients with raised ICP

Keywords

Arterial Blood Pressure Intracranial Pressure Subarachnoid Hemorrhage Antihypertensive Drug Intracranial Hypertension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bauer JH, Reams GP (1987) The role of calcium entry blockers in hypertensive emergencies. Circulation [Suppl V] 75: 174–181Google Scholar
  2. Giffin JP, Cottel JE, Hartung J, Shwiry B (1983) Intracranial pressure during nifedipine-induced hypotension. Anesth Analg 62: 1078–1080CrossRefGoogle Scholar
  3. Hayashi M, Kobayashi H, Kawano H, Handa Y, Kabuto M (1987) The effects of local intrapar-enchymal pentobarbital on intracranial hypertension following experimental subarachnoid hemorrhage. Anesthesiology 66: 758–765PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • S. Hirose
    • 1
  • Y. Handa
    • 1
  • M. Hayashi
    • 1
  • N. Shirasaki
    • 1
  • H. Kobayashi
    • 1
  • H. Kawano
    • 1
  1. 1.Department of NeurosurgeryFukui Medical SchoolMatsuoka-cho, Yoshida-gun, FukuiJapan

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