Experimental Cerebral Edema, Isotonic Intravenous Infusions, Mannitol, Serum Osmolality, Electrolytes, Brain Water, Intracranial Pressure, and Cerebral Blood Flow

  • H. E. James
  • S. Schneider
  • S. Bhasin
  • T. G. Luerssen
Conference paper

Abstract

Mannitol and intravenous fluid resuscitation are therapies that are commonly employed in multiple trauma. Much discussion exists as to the correct dosage of mannitol, but the concomitant fluid resuscitation, mannitol and response to this agent, has received limited attention (James 1980). The current study addresses isotonic saline hydration, mannitol, ICP and CBF.

Keywords

Catheter Hydration Platinum Mannitol Halothane 

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References

  1. James HE (1980) Methodology for control of intracranial pressure with hypertonic mannitol. Acta Neurochir (Wien) 51: 161–172CrossRefGoogle Scholar
  2. James HE, Laurin RA (1981) Intracranial hypertension and brain edema in albino rabbits. Part 1. Experimental models. Acta Neurochir (Wien) 55: 213–226CrossRefGoogle Scholar
  3. Javid M, Gilboe D, Cesario T (1964) The rebound phenomenon and hypertonic solutions. J Neurosurg (Wien) 21: 1059–1066Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. E. James
    • 1
  • S. Schneider
    • 1
  • S. Bhasin
    • 1
  • T. G. Luerssen
    • 1
  1. 1.Division of Neurosurgery/Surgery and the Department of Pediatrics, School of MedicineUniversity of CaliforniaSan DiegoUSA

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