Advertisement

Redox-Active Iron-Chelators based on Pyridoxal

  • S. Avramovici-Grisaru
  • S. Sarel
Conference paper

Abstract

Electron spin resonance (ESR) and cyclicvoltametric (CV) studies indicate that pyridoxal-based iron chelators of general structure (I) are capable, through metal sequestration (I → II), of transfering single electrons from ferrous ions (II–III) towards the electron-deficient center to yield a free-radical of presumed structure (III). In presence of appropriate electron acceptors [Acc], (III) converts to (IV) with concommitant formation of the corresponding anion radical [Acc]∸. In absence of suitable an electron-acceptor, the intermediacy of a nitrogen-centrered free radical is involved to rationalize the observed generation of double-decomposition products1. Data in substantiation of this view will be presented.

Keywords

Physical Chemistry Organic Chemistry Free Radical Electron Spin Resonance General Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1).
    S. Avramovici-Grisaru and S. Sarel, Chem. Comm. 1986.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • S. Avramovici-Grisaru
    • 1
  • S. Sarel
    • 1
  1. 1.The Hebrew University School of PharmacyJerusalemIsrael

Personalised recommendations