Free Radicals in the Catalytic Chemistry of Hemoproteins

  • Paul R. Ortiz de Montellano
Conference paper


The monooxygenases and peroxidases, two of the major types of catalytic hemoproteins, are catalytically distinguished in that cytochrome P-450 enzymes transfer an oxygen atom to their substrates whereas peroxidases abstract one electron from theirs. In general, diffusible free radicals are produced by the peroxidases but not monooxygenases. Solid evidence nevertheless suggests that cytochrome P450-catalyzed reactions proceed via free radical intermediates that are trapped before they diffuse away from the enzymatically generated ferryl oxygen species.


Azide Hydrazine Dehydrogenation Ferricyanide Dihydropyridines 


  1. 1.
    Ortiz de Montellano, PR (1987) Accounts Chemical Research 20:289CrossRefGoogle Scholar
  2. 2.
    Ator, MA, Ortiz de Montellano, PR (1987) J. Biol. Chem. 262: 1542Google Scholar
  3. 3.
    Augusto, O., Beilan, HS, Ortiz de Montellano, PR (1982) J. Biol. Chem. 257:11288Google Scholar
  4. 4.
    Lee, JA, Jacobsen, NE, Ortiz de Montellano, PR, Biochemistry, submitted for publication.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Paul R. Ortiz de Montellano
    • 1
  1. 1.Department of Pharmaceutical ChemistrySchool of Pharmacy, University of CaliforniaSan FranciscoUSA

Personalised recommendations