Abstract
The monooxygenases and peroxidases, two of the major types of catalytic hemoproteins, are catalytically distinguished in that cytochrome P-450 enzymes transfer an oxygen atom to their substrates whereas peroxidases abstract one electron from theirs. In general, diffusible free radicals are produced by the peroxidases but not monooxygenases. Solid evidence nevertheless suggests that cytochrome P450-catalyzed reactions proceed via free radical intermediates that are trapped before they diffuse away from the enzymatically generated ferryl oxygen species.
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References
Ortiz de Montellano, PR (1987) Accounts Chemical Research 20:289
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Lee, JA, Jacobsen, NE, Ortiz de Montellano, PR, Biochemistry, submitted for publication.
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© 1988 Springer-Verlag Berlin Heidelberg
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de Montellano, P.R.O. (1988). Free Radicals in the Catalytic Chemistry of Hemoproteins. In: Fischer, H., Heimgartner, H. (eds) Organic Free Radicals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73963-7_75
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DOI: https://doi.org/10.1007/978-3-642-73963-7_75
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50129-9
Online ISBN: 978-3-642-73963-7
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