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Charge Transfer Interaction Between Menadione and Nucleic Acids. A CIDNP Study.

  • J. Marko
  • G. Vermeersch
  • V. Toebat
  • N. Febvay
  • A. Lablache-Combier
Conference paper

Abstract

2-Methyl-l,4-naphthoquinone or menadione (MQ) ,which is a component of vitamin K3 , is known to photooxidize various pyrimidine bases from ADN upon exposure to UV light (1) It seems very likely that a pyrimidine cation radical should be formed as a primary intermediate in these photoreactions, as suggested by flash photolysis experiments (2). This cation radical should lead to the various photoproducts obtained through the sensitized photooxidation of thymidine (3) or 2′-desoxycytidine (4) by MQ. It should result from a charge transfer reaction between MQ in its triplet excited state and the pyrimidine.

Keywords

Dynamic Nuclear Polarization Triplet Excited State Charge Transfer Reaction Pyrimidine Base Charge Transfer Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. Marko
    • 1
  • G. Vermeersch
    • 1
  • V. Toebat
    • 1
  • N. Febvay
    • 1
  • A. Lablache-Combier
    • 1
    • 2
  1. 1.Lab. de Physique, Faculté de PharmacieLille-CédexFrance
  2. 2.Lab.de Chimie Organique Physique, associé à l’ENSCLVilleneuve D’ascq-CédexFrance

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