Charge Transfer Interaction Between Menadione and Nucleic Acids. A CIDNP Study.

  • J. Marko
  • G. Vermeersch
  • V. Toebat
  • N. Febvay
  • A. Lablache-Combier
Conference paper

Abstract

2-Methyl-l,4-naphthoquinone or menadione (MQ) ,which is a component of vitamin K3 , is known to photooxidize various pyrimidine bases from ADN upon exposure to UV light (1) It seems very likely that a pyrimidine cation radical should be formed as a primary intermediate in these photoreactions, as suggested by flash photolysis experiments (2). This cation radical should lead to the various photoproducts obtained through the sensitized photooxidation of thymidine (3) or 2′-desoxycytidine (4) by MQ. It should result from a charge transfer reaction between MQ in its triplet excited state and the pyrimidine.

Keywords

Porphyrin Adenine Pyrimidine Thymidine Photolysis 

References

  1. 1.
    Wagner JR , Cadet J. Fisher GJ (1984) Photochem. Photobiol. 40 589CrossRefGoogle Scholar
  2. 2.
    Fisher GJ, Land EJ (1983) Photochem. Photobiol. 37:27CrossRefGoogle Scholar
  3. 3.
    Decarroz C, Wagner JR , Van Lier JE , Murali-Krishna C , Riesz P , Cadet J (1986) Int. J . Radiat. Biol. 50:491CrossRefGoogle Scholar
  4. 4.
    Murali-Krishna C, Decarroz C, Wagner JR , Cadet J, Riesz P (1987) Photochem. Photobiol. 46:175CrossRefGoogle Scholar
  5. 5.
    Marko J. Veraeersch G. Febvay N. Lablache Combier A (1985) Photochem. Photobiol. 42:213CrossRefGoogle Scholar
  6. 6.
    Le Nouen D, Marko J, Vermeersch G. Febvay N, Lablache-Combier A. Perrée-Fauvet M , Gaudemer A (1988) Photochem. Photobiol. to be publishedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. Marko
    • 1
  • G. Vermeersch
    • 1
  • V. Toebat
    • 1
  • N. Febvay
    • 1
  • A. Lablache-Combier
    • 1
    • 2
  1. 1.Lab. de Physique, Faculté de PharmacieLille-CédexFrance
  2. 2.Lab.de Chimie Organique Physique, associé à l’ENSCLVilleneuve D’ascq-CédexFrance

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