Charge Transfer Interaction Between Menadione and Nucleic Acids. A CIDNP Study.
2-Methyl-l,4-naphthoquinone or menadione (MQ) ,which is a component of vitamin K3 , is known to photooxidize various pyrimidine bases from ADN upon exposure to UV light (1) It seems very likely that a pyrimidine cation radical should be formed as a primary intermediate in these photoreactions, as suggested by flash photolysis experiments (2). This cation radical should lead to the various photoproducts obtained through the sensitized photooxidation of thymidine (3) or 2′-desoxycytidine (4) by MQ. It should result from a charge transfer reaction between MQ in its triplet excited state and the pyrimidine.
KeywordsPorphyrin Adenine Pyrimidine Thymidine Photolysis
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