Ecodynamics pp 276-284 | Cite as

The Role of Theoretical Research in the Design of Programmes for the Control of Infectious Disease Agents

  • G. F. Medley
Conference paper
Part of the Research Reports in Physics book series (RESREPORTS)


The work which forms the subject of this paper directly addresses serious, medical problems for which there is a urgent need for solutions. The purpose of modelling the population dynamics of infectious disease agents is to gain greater conceptual understanding of their population dynamics. This knowledge can then be used to design control programmes with the associated alleviation of suffering and economic benefits. The greatest progress in development of control programme design has been achieved by proposing solutions to problems and monitoring their effects when implemented. As is generally the case in ecology, we can learn most about the processes operating by monitoring a population or ecosystem during a deliberate or accidental perturbation. Thus models have two roles in epidemiology: firstly to mimic population dynamics, and secondly to interact with observational and experimental data. It is the impact that theoretical ecology has on the collection and analysis of data that we wish to emphasise here.


Human Immunodeficiency Virus Acquire Immune Deficiency Syndrome Acquire Immunodeficiency Syndrome Parasite Population Worm Burden 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. /1/.
    Cox, F.E.G.: Modern Parasitology. Blackwell Scientific Publications, Oxford 1982.Google Scholar
  2. /2/.
    Anderson, R.M.: Population dynamics and control of hookworm and roundworm infections. In Population Dynamics of Infectious Diseases: Theory and Applications (ed. R.M. Anderson). Chapman & Hall, London 1982.Google Scholar
  3. /3/.
    Peters, W.: Medical aspects: comments and discussion II. in The Relevance of Parasitology to Human Welfare Today, (eds. Taylor, A.E. & Muller, R.). Blackwell Scientific Publications, Oxford 1978.Google Scholar
  4. /4/.
    Anderson, R.M. & Medley, G.F.: Community control of helminth infections of man by mass and selective chemotherapy. Parasitology, 90 (1985), 629–660.CrossRefGoogle Scholar
  5. /5/.
    Bundy, D.A.P., Cooper, E.S., Thompson, D.E., Anderson, R.M. & Didier, J.M.: Age-related prevalence and intensity in a St. Lucian Community. Trans. Roy. Soc. Trop. Med. Hyg., 81 (1987), 85–94.CrossRefGoogle Scholar
  6. /6/.
    Medley, G.F. & Anderson, R.M.: manuscript in preparation.Google Scholar
  7. /7/.
    Anderson, R.M. & May, R.M.: Helminth infections of humans: mathematical models, population dynamics and control. Adv. Parasit, 24 (1985), 1–101.CrossRefGoogle Scholar
  8. /8/.
    Haswell-Elkins, M.R., Elkins, D.B. & Anderson, R.M.: Evidence of predisposition in humans to infection with Ascaris, hookworm, Enterobius and Trichuris in a South Indian fishing community. Parasitology, 95 (1987), 323–337.CrossRefGoogle Scholar
  9. /9/.
    Wong, M., Project Coordinator, Parasite Control Programme, Montserrat, West Indies: personal communication.Google Scholar
  10. /10/.
    Hominick, W.H., Dean, C.G., Schad, G.A.: Population biology of hookworms in West Bengal: analysis of numbers of infective larvae recovered from damp pads applied to the soil surface at defaecation sites. Trans. Roy. Soc. Trop. Med. Hyg. (in the press).Google Scholar
  11. /11/.
    Bundy, D.A.P., Cooper, E.S., Thompson, D.E., Didier, J.M. & Simmons, L: Epidemiology and population dynamics of Ascaris lumbricoides and Trichuris trichiura infection in the same community. Trans. Roy. Soc. Trop. Med. Hyg., (in the press).Google Scholar
  12. /12/.
    Bundy, D.A.P., Lecturer, Parasite Epidemiology Research Group, Imperial College: personal communication.Google Scholar
  13. /13/.
    Elkins, D.B.: The epidemiology and control of Ascaris lumbricoides in a Indian fishing community. Ph.D. Thesis, University of London (1987).Google Scholar
  14. /14/.
    Elkins, D.B., Haswell-Elkins, M. & Anderson, R.M.: The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India. I. Study design and pre-and post-treatment observations on Ascaris lumbricoides infection. Trans. Roy. Soc. Trop. Med. Hyg., 80 (1986), 774–792.CrossRefGoogle Scholar
  15. /15/.
    Tallis, G.M. & Leyton M.K: Stochastic models of populations of helminth parasites in the definitive host. Math. Biosci., 4 (1969), 39–48.CrossRefGoogle Scholar
  16. /16/.
    Anderson, R.M., Medley, G.E, May, R.M. & Johnson, A.M.: A preliminary study of the transmission dynamics of the human immunodeficiency virus (HIV), the causative agent of AIDS. IMA J. Math. App. Med. Biol., 3 (1986), 229–263.CrossRefGoogle Scholar
  17. /17/.
    Anderson, R.M., Medley, G.F., Blythe, S.P. & Johnson, A.M.: Is it possible to predict the minimum size of the acquired immunodeficiency syndrome (AIDS) epidemic in the United Kingdom? The Lancet 1 1987; 1073–1075.CrossRefGoogle Scholar
  18. /18/.
    Peterman, T.A., Drotman, D.P. & Curran, J.W.: Epidemiology of the acquired immunodeficiency syndrome (AIDS), Epidemiol. Rev., 7 (1985), 1–21.Google Scholar
  19. /19/.
    Medley, G.F., Anderson, R.M., Cox, D.R. & Billard, L.: Incubation period of AIDS in patients infected via blood transfusion. Nature, 328 (1987), 719–721.CrossRefGoogle Scholar
  20. /20/.
    Billard, L., Cox, D.R., Medley, G.E & Anderson, R.M.: The distribution of the incubation period for the acquired immune deficiency syndrome (AIDS), (manuscript in preparation).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. F. Medley
    • 1
  1. 1.Parasite Epidemiology Research Group, Department of Pure and Applied BiologyImperial CollegeLondonUK

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