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Stellenwert von Prostaglandin E1 (PGE1) in der Diagnostik und Therapie der erektilen Dysfunktion

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Zusammenfassung

Die intrakavernöse Testung mit vasoaktiven Substanzen wie Papaverin bzw. Papaverin/Phentolamin ist seit der Publikation von Virag 1982 im Lancet [27] zunehmend in den Mittelpunkt des diagnostischen und auch therapeutischen Interesses bei erektiler Dysfunktion (ED) gerückt [1, 2, 4, 5, 7–9, 16–19, 22–24, 26, 28–30]. Bisheriges Hauptproblem in der intrakavernösen Applikation vasoaktiver Substanzen stellte die Induktion interventionsbedürftiger Priapismen von über 6 h Dauer dar, deren Häufigkeit eine deutliche Abhängigkeit von der jeweiligen Patientenselektion zeigt und deshalb in der Literatur zwischen 2% und 15% schwankt [5, 9, 10, 18, 24, 26, 30].

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Literatur

  1. Abber JC, Lue TF, Orvis BR, McClure RD, Williams RD (1986) Diagnostic tests for impotence: A comparison of papaverine injection with the penile brachial index and nocturnal penile tumescence monitoring. J Urol 135: 923–925

    CAS  PubMed  Google Scholar 

  2. Abozeid M, Juenemann K-P, Luo J-A, Lue TF, Yen T-SB, Tanagho EA (1987) Chronic papaverine treatment: The effect of repeated injections on the Simian erectile response and penile tissue. J Urol 138: 1263–1266

    CAS  PubMed  Google Scholar 

  3. Adaikan PG, Kottegoda SR, Ratnam SS (1986) A possible role for Prostaglandin E1 in human penile erection. Abstract 2. 6, Second World Meeting on Impotence, Prag.

    Google Scholar 

  4. Bähren W, Stief Ch, Scherb W, Gall H, Gallwitz A, Altwein JE (1986) Rationelle Diagnostik der erektilen Dysfunktion unter Anwendung eines pharmakologischen Tests. Aktuel Urol 17: 177–180

    Article  Google Scholar 

  5. Bodner DR, Lindan R, Leffler E, Kursh ED, Resnick MI (1987) The application of intracavernous injection of vasoactive medications for erection in men with spinal cord injury. JUrol 138: 310–311

    CAS  Google Scholar 

  6. Bollinger A, Rogatti W (1987) Clinical relevance of Prostaglandin E1. Vasa, Supplement 17

    Google Scholar 

  7. Brindley GS (1983) Cavernosal alpha blockade: A new technique for investigating and treating erectile impotence. Br J Psych 143: 332–335

    Article  CAS  Google Scholar 

  8. Buvat J, Lemaire A, Marcolin G, Dehaene JL, Buvat-Herbaut M (1987) Intracavernous injection of papaverine (ICIP). Assessment of its diagnostic and therapeutic value in 100 impotent patients. World J Urol 5: 150–155

    Article  Google Scholar 

  9. Gasser TC, Roach RM, Larsen EH, Madsen PO, Bruskewitz RC (1987) Intracavernous self-injection with phentolamine and papaverine for the treatment of impotence. J Urol 137: 678–680

    CAS  PubMed  Google Scholar 

  10. Halsted DS, Weigel JW, Noble MJ, Mebust WK (1986) Papaverine induced priapism: 2 case reports. J Urol 136: 109–110

    CAS  PubMed  Google Scholar 

  11. Hashmat AI, Abraham J (1987) Papaverine induced priapism, a letal complication. J Urol 137 Number 4, Part 2:201 A

    Google Scholar 

  12. Hedlund A, Andersson K-E (1985) Contraction and relaxation induced by some Prostanoids in isolated human penile erectile tissue and cavernous artery. J Urol 134: 1245–1250

    CAS  PubMed  Google Scholar 

  13. Hue K-N, Burks C, Christy WC (1987) Fibrosis of tunica albuginea: Complication of long-term intracavernous pharmacological self-injection. J Urol 138: 404–405

    Google Scholar 

  14. Ishii N, Watanabe H, Irisawa C, Kikuchi Y (1986) Therapeutic trial with Prostaglandin E1 for organic impotence. Abstract 11. 2, Second World Meeting on Impotence, Prag

    Google Scholar 

  15. Larsen EH, Gasser TC, Bruskewitz RC (1987) Fibrosis of corpus cavernosum after intra-cavernous injection of phentolamine/papaverine. J Urol 137: 292–293

    CAS  PubMed  Google Scholar 

  16. Lue TF, Tanagho EA (1987) Physiology of erection and pharmacological management of impotence. J Urol 137: 829–836

    CAS  PubMed  Google Scholar 

  17. Nellans RE, Ellis LR, Kramer-Levien D (1987) Pharmacological erection: Diagnosis and treatment applications in 69 patients. J Urol 138: 52–54

    CAS  PubMed  Google Scholar 

  18. Padma-Nathan H, Goldstein I, Payton T, Krane RJ (1987) Intracavernosal pharmacotherapy: The pharmacologic erection program. World J Urol 5: 160–165

    Article  Google Scholar 

  19. Porst H, van Ahlen H (1987) Dynamische Cavernosographie und Schwellkörper-Pharmakontestung in der Diagnostik der erektilen Dysfunktion. Urologe A 26: 152–157

    CAS  PubMed  Google Scholar 

  20. Porst H, Tackmann W, van Ahlen H (1987) Bulbokavernosusreflex-Latenzzeitmessung (BCR) und somatosensorisch evozierte Potentiale ( SSEP) in der Diagnostik der erektilen Dysfunktion. Aktuel Urol 18: 198–202

    Article  Google Scholar 

  21. Porst H, van Ahlen H, Vahlensieck W (1987) Relevance of dynamic cavernosography to the diagnosis of venous incompetence in erectile dysfunction. J Urol 137: 1163–1167

    CAS  PubMed  Google Scholar 

  22. Porst H (1987) Erektile Impotenz. Ätiologie, Diagnostik, Therapie. Ferdinand Enke Verlag, Stuttgart

    Google Scholar 

  23. Porst H, van Ahlen H, Köster O, Schlolaut K-H (1988) Vergleich von Papaverininduzierter Doppler-Sonographie und Angiographie in der Diagnostik der erektilen Dysfunktion. Urologe A, 27: 8–13

    CAS  PubMed  Google Scholar 

  24. Sidi AA, Chen K-K (1987) Clinical experience with vasoactive intracavernous pharmaco-therapy for treatment of impotence. World J Urol 5: 156–159

    Article  Google Scholar 

  25. Stackl W, Loupal G, Holzmann A (1986) Intracavernous injection of vasoactive drugs in the rabbit. Abstract 11. 16, Second World Meeting on Impotence, Prag

    Google Scholar 

  26. Stief CG, Bähren W, Gall H, Scherb W, Gallwitz A, Altwein JE (1986) Schwellkörper-Autoinjektionstherapie (SKAT): Erste Erfahrungen bei erektiler Dysfunktion. Urologe A 25: 63–66

    CAS  PubMed  Google Scholar 

  27. Virag R (1982) Intracavernous injection of papaverine for erectile failure. Lancet 11: 938

    Article  Google Scholar 

  28. Virag R, Sussman H, Floresco J, Shoukry K (1987) Late results on the treatment of neurogenic impotence by self-intracavernous-injection ( SICI) of vasoactive drugs. World J Urol 5: 166–170

    Article  Google Scholar 

  29. Virag R, Adaikan PG (1987) Effects of Prostaglandin E1 on penile erection and erectile failure. Letters to the editor. J Urol 137: 1010

    CAS  PubMed  Google Scholar 

  30. Zorgniotti AW, Lefleur RS (1985) Auto-injection of the corpus cavernosum with a vasoactive drug combination for vasculogenic impotence. J Urol 133: 39–41

    CAS  PubMed  Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg

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Porst, H., Rogatti, W. (1988). Stellenwert von Prostaglandin E1 (PGE1) in der Diagnostik und Therapie der erektilen Dysfunktion. In: Heidrich, H., Böhme, H., Rogatti, W. (eds) Prostaglandin E1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73943-9_21

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  • DOI: https://doi.org/10.1007/978-3-642-73943-9_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73944-6

  • Online ISBN: 978-3-642-73943-9

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