Connectors of Supramolecular Assemblies
An underlying theme of this meeting is the search for potential biophysical relationships between the extracellular matrix and the cytoskeleton. We found that the fruit fly, Drosophila melanoqaster. shares with vertebrates some major extra-cellular matrix components that are adjacent to cell surfaces, and also a transmembrane receptor of the integrin type. Actin filaments are probably indirectly linked to the cytoplasmic portion of such receptors in vertebrates and very similar actins exist in Drosophila. This suggests that parts of the molecular relationships between the extracellular matrix and the cytoplasm have been conserved during evolution, and that these mechanisms are likely to have important roles in cell biology.
KeywordsBasement Membrane Supramolecular Assembly Basement Membrane Component Actual Amino Acid Basement Membrane Collagen
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