Procollagen Processing Control of Type I Collagen Fibril Assembly
Vertebrate collagens constitute a family of at least twelve genetic types that shows remarkable diversity in molecular structure and supramolecular assembly (Mayne & Burgeson, 1987). Types I, II and III collagens assemble in vivo to form fibrils of uniform diameter, near circular cross-section and with a characteristic axial periodicity of 65 to 67 nm (D). Fibrils in vivo are long (several µm) and diameters range from 8 nm to 500 nm, depending on collagen type, species, age and tissue of origin (Parry & Craig, 1984). The mechanisms that control fibril shape and diameter in vivo are poorly understood.
KeywordsCollagen Fibril Fibril Formation Supramolecular Assembly Processing Intermediate Wide Sheet
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