Abstract
Hexabrachion/tenascin is an extracellular matrix protein with a distinct spatial and temporal distribution in tissue (Erickson and Lightner, 1988). In chicken embryo fibroblast cultures it is isolated as a hexameric protein with disulfide linked subunits of 250, 225 and 215 Kd (Chiquet and Fambrough, 1984a,b; Erickson and Lightner, 1988). These subunits have very similar proteolytic cleavage patterns, indicating they are related peptides (Chiquet and Fambrough, 1984b). Pulse chase experiments (Chiquet and Fambrough, 1984b) and recently published sequence data (Jones et al.,1988; Pearson et al.,1988) suggest they result from alternative splicing of the tenascin mRNA. However, nothing is known about the functional differences between these subunits or how they are assembled into the hexameric structure.
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© 1989 Springer-Verlag Berlin Heidelberg
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Lightner, V.A., Pegram, C., Bigner, D., Erickson, H.P. (1989). Monoclonal Antibody 127 Recognizes a Subpopulation of Chicken Hexabrachion/Tenascin. In: Aebi, U., Engel, J. (eds) Cytoskeletal and Extracellular Proteins. Springer Series in Biophysics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73925-5_23
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DOI: https://doi.org/10.1007/978-3-642-73925-5_23
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