The Australian Sodium Potassium Study in Untreated Mild Hypertension
Moderate reduction in sodium intake has been shown to reduce blood pressure in people with hypertension (Parijs et al. 1973; Morgan et al. 1978; Beard et al. 1982; Morgan et al. 1986). Dietary intervention studies are difficult to blind and control, and alteration in other nutrients associated with the advice to reduce sodium intake may have contributed to the fall in blood pressure. In double-blind studies, Morgan (1982) and Maregoret al. (1982) have shown that sodium chloride tablets prevent this fall. Watt et al. (1983) could not repeat this observation, but their patients prior to dietary advice were not hypertensive and their power to detect small changes was low. Despite some 50 studies (see Morgan and Nowson 1986) that have shown a fall in blood pressure in hypertensive patients with reduction in sodium intake, there is resistance to the suggestion that this is a practical form of therapy to use in hypertension based on the following reasoning: firstly, that a low-sodium diet does not reduce blood pressure; secondly, that even if a reduced-sodium diet lowers blood pressure, it is not due to the sodium; thirdly, such a diet alteration cannot be obtained in a community setting (Logan 1986; Neyses et al. 1985); and fourthly, that it may be dangerous in some people, causing blood pressure to rise and making them more prone to volume depletion and complications if they are involved in accidents (Brown et al. 1984).
KeywordsPlacebo Magnesium Urea Carbohydrate Creatinine
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- Australian National Health and Medical Research Council Management Committee (1987) Australian dietary salt study in mild hypertension: study design, protocol, and pilot study. In: Strasser T, Ganten D (eds) Mild hypertension: from drug trials to practice, pp 165–180Google Scholar
- Chalmers J, Morgan TO, Doyle A, Dickson B, Hopper J, Matthews J, Matthews G, Moulds R, Myers J, Nowson C, Scoggins, Stebbing M (1986) Australian dietary salt study in mild hypertension. Hypertens [Suppl 6]:S629–637Google Scholar
- Morgan T (1982) The effect of potassium and bicarbonate ions on the rise in blood pressure caused by sodium chloride. Clin Sci 63:407S-409SGoogle Scholar
- Neyses L, Dorst K, Michaelis J, Berress M, Philipp T, Distler A, Losse H, Vetler H, Epstein FH, Vetler W (1985) Compliance with salt restriction as a limiting factor in the primary prevention of hypertension. J Hypertens 3 [Suppl 1]:87–90Google Scholar