Abstract
Data is accumulating which suggests that the roots of primary hypertension may be found in childhood (Hofman et al. 1987). This notion provides a rationale for directing attention to the part played by electrolyte intake in the elevation of blood pressure, even at a young age. First, it may be that the mechanisms that relate various electrolytes to blood pressure regulation are different at different stages of the development of high blood pressure. This could imply that etiologically important relationships may only be observed at a relatively young age. Second, since blood pressure in childhood and adolescence is related to blood pressure later in life, attempts to lower blood pressure levels or to prevent the development of hypertension should start as early as possible. Manipulating dietary electrolyte intake could, if proven to be effective, provide a useful means of intervention in this age group.
Part of this work was supported by a grant from the Netherlands Heart Foundation
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References
Armstrong BK, Margetts BM, McCall MG, Binns CW, Campbell NA, Masarei JRL (1982) Water sodium and blood pressure in rural school children. Arch Environ Health 37:236–245
Belizan JM, Villar J, Pineda O, Gonzalez AE, Sainz E, Garrere G, Sibrian R (1983) Reduction of blood pressure with calcium supplementation in young adults. JAMA 249:1161–1166
Bulpitt CJ (1984) Cation consumption and blood pressure. Neth J Med 27:95–100
Calabrese EJ, Tuthill RW (1977) Elevated blood pressures and high sodium levels in the public drinking water. Arch Environ Health 32:200–202
Connor SL, Connor WE, Henry H, Sexton G, Keenan EJ (1984) The effects of familial relationships, age, body weight, and diet on blood pressure and the 24-hour urinary excretion of sodium, potassium, and creatinine in men, women, and children of randomly selected families. Circulation 70:76–85
Cooper R, Soltero I, Liu K, Berkson D, Levinson S, Stamler J (1980) The association between urinary sodium excretion and blood pressure in children. Circulation 62:97–104
Cooper R, Liu K, Trevisan M, Miller W, Stamler J (1983) Urinary sodium excretion and blood pressure in children: absence of a reproducible association. Hypertension 5:135–139
Cooper R, Van Horn L, Liu K, Trevisan M, Nanas S, Ueshima H, Larbi E, Yu CS, Sempos C, LeGrady D, Stamler J (1984) A randomized trial on the effect of decreased dietary sodium intake on blood pressure in adolescents. J Hypertens 2:361–366
Gillum RF, Elmer PJ, Prineas RJ, Surbey MA, (1981) Changing sodium intake in children. The Minneapolis children’s blood pressure study. Hypertension 3:698–703
Grobbee DE, Hofman A (1986a) Does sodium restriction lower blood pressure? Br Med J 293: 27–29
Grobbee DE, Hofman A (1986b) Effect of calcium supplementation on diastolic blood pressure in young people with mild hypertension. Lancet 11:703–706
Grobbee DE, Hofman A, Roalandt JF, Boomsma F, Schalekamp MA, Valkenburg HA (1987) Sodium restriction and potassium supplementation in young people with mildly elevated blood pressure. 5:115–119
Grobbee DE, Hackeng WHL, Birkenhäger JC, Hofman A (1988) Raised plasma intact parathyroid hormone concentrations in young people with mildly raised blood pressure. Br Med J 296:814–816
Hofman A, Valkenburg HA (1980) Increased blood pressure in schoolchildren related to high sodium levels in drinking water. J Epidemiol Community Health 34:179–181
Hofman A, Hazebroek A, Valkenburg HA (1983) A randomized trial of sodium intake and blood pressure in newborn infants. JAMA 250:370–374
Hofman A, Grobbee DE, Schalekamp MADH (eds) (1987) The early pathogenesis of primary hypertension. Elsevier, Amsterdam
Jenner DA, English DR, Vandongen R, Beilin LJ, Armstrong BK, Miller MR, Dunbar D (1988) Diet and blood pressure in 9-year-old Australian children. Am J Clin Nutr (in press)
Khaw KT, Thom S (1982) Randomized double-blind crossover trial of potassium on blood pressure in normal subjects. Lancet 11:1127–1129
Langford HG, Watson RL (1975) Electrolytes and hypertension. In: Paul O (ed) Epidemiology and control of hypertension, Vol 51. Year Book Medical, Chicago, pp 103–5
Lever AF, Beretta-Piccoli C, Brown JJ, Davis DL, Fräser R, Robertson JIS (1981) Sodium and potassium in essential hypertension. Br Med J 102:359–373
McCarron DA (1985) Is calcium more important than sodium in the pathogenesis of essential hypertension? Hypertension 7:607–627
Persson LA (1984) Dietary habits and health risks in Swedish children. Human Nutr 38C:287–297
Robertson JS (1984) Water sodium, urinary electrolytes, and blood pressure of adolescents. J Epidemiol Community Health 38:186–194
Sasaki N, Mitsuhashi T, Fukushi S (1959) Effects of the ingestion of large amounts of apples on blood pressure in farmers in Akita prefecture. Igaku To Scibutsugaku 51:103–105
Skrabal F et al. (1981) Low sodium/high potassium diet for prevention of hypertension: probable mechanisms of action. Lancet 895–900
Skrabal F, Kotanko P, Meister B, Doll P, Gruber G (1986) Up-regulation of alpha2-adrenoceptors and down-regulation of beta2-adrenoceptors by high-salt diet in normotensive men: enhanced up- regulation of operative (alpha2:beta2)-adrenoceptor ratio predicts salt sensitivity. J Hypertens 4:196–199
Swales JD (1987) Potassium and blood pressure. Libbey, London
Treasure J, Ploth D (1983) Role of dietary potassium in the treatment of hypertension. Hypertension 5:864–872
Watson RL, Langford HG, Abernethy J, Barnes TY, Watson MJ (1980) Urinary electrolytes, body weight, and blood pressure. Hypertension 2:93–98
Watt GCM, Foy CJW, Hart JT, Bingham G, Edwards C, Hart M, Thomas E, Walton P (1985) Dietary sodium and arterial blood pressure: evidence against genetic susceptibiliy. Br Med J 291: 1525–1528
Weinberger MH, Miller JZ, Fineberg NS, Luft FC, Grim CE, Christian JC (1987) Association of haptoglobin with sodium sensitivity and resistance of blood pressure. Hypertension 10:443–446
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Grobbee, D.E., Bak, A.A.A. (1989). Electrolyte Intake and Hypertension in Children. In: Rettig, R., Ganten, D., Luft, F.C. (eds) Salt and Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73917-0_26
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DOI: https://doi.org/10.1007/978-3-642-73917-0_26
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