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The Calcium Channel: Structure, Function and Implications pp 465–477Cite as

Increased Calcium Currents in Rat Hippocampal Neurons During Aging

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Part of the book series: Bayer AG Centenary Symposium ((BAYER))

Abstract

This paper will review evidence from our laboratory which indicates that calcium currents in rat hippocampal neurons are increased with aging and that these alterations may playa key role in functional and morphological brain changes during aging. In addition, evidence will be reviewed to show that a form of calcium-dependent inactivation of calcium currents, which had been seen previously only in invertebrate neurons, is also present in mammalian hippocampal neurons. It is not clear whether changes in this inactivation mechanism are responsible for age-related changes in hippocampal calcium current (ICa), but this possibility is presently under active investigation.

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Author information

Authors and Affiliations

  1. Department of Physiology and Pharmacology, Bowman Gray School of Medicine, of Wake Forest University, 300 South Hawthorne Road, Winston-Salem, N.C., 27103, USA

    P. W. Landfield

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  1. P. W. Landfield
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Pennsylvania, Philadelphia, PA, 19104-6085, USA

    Martin Morad (Professor of Physiology and Medicine) (Professor of Physiology and Medicine)

  2. Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, 3084, Victoria, Australia

    Winifred G. Nayler (Principal Research Investigator) (Principal Research Investigator)

  3. Bayer AG, Institute of Pharmacology, Aprather Weg 18a, D-5600, Wuppertal 1, Germany

    Stanislav Kazda (Associate Professor of Pharmacology and Toxicology) & Matthias Schramm (Associate Professor of Physiology) (Associate Professor of Pharmacology and Toxicology) &  (Associate Professor of Physiology)

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© 1988 Springer-Verlag Berlin Heidelberg

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Landfield, P.W. (1988). Increased Calcium Currents in Rat Hippocampal Neurons During Aging. In: Morad, M., Nayler, W.G., Kazda, S., Schramm, M. (eds) The Calcium Channel: Structure, Function and Implications. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73914-9_37

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  • DOI: https://doi.org/10.1007/978-3-642-73914-9_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50061-2

  • Online ISBN: 978-3-642-73914-9

  • eBook Packages: Springer Book Archive

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