Increased Calcium Currents in Rat Hippocampal Neurons During Aging

  • P. W. Landfield
Part of the Bayer AG Centenary Symposium book series (BAYER)

Abstract

This paper will review evidence from our laboratory which indicates that calcium currents in rat hippocampal neurons are increased with aging and that these alterations may playa key role in functional and morphological brain changes during aging. In addition, evidence will be reviewed to show that a form of calcium-dependent inactivation of calcium currents, which had been seen previously only in invertebrate neurons, is also present in mammalian hippocampal neurons. It is not clear whether changes in this inactivation mechanism are responsible for age-related changes in hippocampal calcium current (ICa), but this possibility is presently under active investigation.

Keywords

Magnesium Depression Ischemia Dementia Serotonin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. W. Landfield
    • 1
  1. 1.Department of Physiology and PharmacologyBowman Gray School of Medicine, of Wake Forest UniversityWinston-SalemUSA

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