The Calcium Channel and Vascular Injury
The specific calcium antagonists have well-defined mechanisms of action and have become tools for identification of the pathogenetic role of calcium ions in a variety of diseases. Hypertension is a typical example. By using verapamil, nifedipine, or diltiazem it was possible to show that increased transmembrane calcium availability in the small resistance vessels is the cause of elevated vascular tone in experimental or human hypertension (Aoki et al. 1976; Lederballe-Pedersen 1981). Moreover, the calcium content in vascular wall of spontaneously hypertensive rats with established hypertension progressively increases with increasing age without additional increase in blood pressure.
KeywordsCreatinine Stein Verapamil Renin Nifedipine
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