Molecular Properties of Dihydropyridine-Sensitive Calcium Channels from Skeletal Muscle

  • M. J. Seagar
  • M. Takahashi
  • W. A. Catterall
Conference paper
Part of the Bayer AG Centenary Symposium book series (BAYER)

Abstract

Voltage-sensitive calcium channels provide an essential link between transient changes in membrane potential and a variety of cellular responses. In neurons, calcium influx couples membrane depolarization to transmitter release at the synaptic terminal [1], whereas in the cell body it may activate calcium-dependent potassium channels and thus modulate repetitive firing patterns [2]. In cardiac and smooth muscle tissue, calcium channels mediate excitation-contraction coupling, although in skeletal muscle their physiological role is still a matter for debate [3,4].

Keywords

Sedimentation Polypeptide Disulfide Verapamil Photolysis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. J. Seagar
    • 1
  • M. Takahashi
    • 1
  • W. A. Catterall
    • 1
  1. 1.Department of PharmacologyUniversity of WashingtonSeattleUSA

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