Molecular Properties of Dihydropyridine-Sensitive Calcium Channels from Skeletal Muscle

  • M. J. Seagar
  • M. Takahashi
  • W. A. Catterall
Conference paper
Part of the Bayer AG Centenary Symposium book series (BAYER)


Voltage-sensitive calcium channels provide an essential link between transient changes in membrane potential and a variety of cellular responses. In neurons, calcium influx couples membrane depolarization to transmitter release at the synaptic terminal [1], whereas in the cell body it may activate calcium-dependent potassium channels and thus modulate repetitive firing patterns [2]. In cardiac and smooth muscle tissue, calcium channels mediate excitation-contraction coupling, although in skeletal muscle their physiological role is still a matter for debate [3,4].


Sedimentation Polypeptide Disulfide Verapamil Photolysis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Katz B, Miledi R (1969) J Physiol (London) 203:459–487Google Scholar
  2. 2.
    Adams DJ, Smith SJ, Thompson SJ (1980) Ann Rev Neurosci 3:141–167PubMedCrossRefGoogle Scholar
  3. 3.
    Hagiwara S, Byerly L (1981) Ann Rev Neurosci 4:69–125PubMedCrossRefGoogle Scholar
  4. 4.
    Reuter H (1979) Ann Rev Physiol 41:413–424CrossRefGoogle Scholar
  5. 5.
    Sanchez JA, Stefani E (1978) J Physiol (London) 283:197–209Google Scholar
  6. 6.
    Almers W, Funk R, Palade PT (1981) J Physiol (London) 312:177–207Google Scholar
  7. 7.
    Rosemblatt M, Hidalgo C, Vergara C, Ikemoto N (1981) J Bioi Chern 256:8140–8148Google Scholar
  8. 8.
    Fosset M, Jaimovich E, Delpont E, Lazdunski M (1983) J Bioi Chern 258:6086–6092Google Scholar
  9. 9.
    Glossmann H, Ferry DR, Boschek CB (1983) Naunyn-Schmiedebergs Arch Pharmacol 323:1–11PubMedCrossRefGoogle Scholar
  10. 10.
    Curtis BM, Catterall WA (1983) J Bioi Chern 258:7280–7283Google Scholar
  11. 11.
    Curtis BM, Catterall WA (1984) Biochemistry 23:2113–2118PubMedCrossRefGoogle Scholar
  12. 12.
    Glossmann H, Ferry DR (1983) Naunyn-Schmiedebergs Arch Pharmacol 323:279–291PubMedCrossRefGoogle Scholar
  13. 13.
    Borsotto M, Barhanin J, Norman RI, Lazdunski M (1984) Biochem Biophys Res Commun 122: 1357–1366PubMedCrossRefGoogle Scholar
  14. 14.
    Takahashi M, Seagar MJ, Jones JF, Reber BFX, Catterall WA (1987) Proc Natl Acad Sci USA 84:5478–5482PubMedCrossRefGoogle Scholar
  15. 15.
    Schmid A, Barhanin J, Coppola T, Borsotto M, Lazdunski M (1986) Biochemistry 25:3492–3495PubMedCrossRefGoogle Scholar
  16. 16.
    Ferry DR, Goll A, Glossmann H (1984) FEBS Lett 169:112–167PubMedCrossRefGoogle Scholar
  17. 17.
    Ferry DR, Kampf K, Goll A, Glossmann H (1985) EMBO J 4:1933–1940PubMedGoogle Scholar
  18. 18.
    Galizzi JP, Borsotto M, Barhanin J, Fosset M, Lazdunski M (1986) J Bioi Chern 261:1393–1397Google Scholar
  19. 19.
    Striessing J, Moosburger K, Goll A, Ferry DR, Glossmann H (1986) Eur J Biochem 161:603–609CrossRefGoogle Scholar
  20. 20.
    Reuter H (1974) J Physiol (London) 242:429–451Google Scholar
  21. 21.
    Reuter H (1983) Nature 30:569–574CrossRefGoogle Scholar
  22. 22.
    Tsien RW, Giles W, Greengard P (1972) Nature New Bioi 240:181–183Google Scholar
  23. 23.
    Brum G, Flockerzi V, Osterrieder W, Trautwein W (1983) Pflugers Archiv 398:147–154PubMedCrossRefGoogle Scholar
  24. 24.
    Schmid A, Renaud J, Lazdunski M (1985) J Bioi Chern 260:13041–13046Google Scholar
  25. 25.
    Curtis BM, Catterall WA (1985) Proc Natl Acad Sci USA 82:2528–2532PubMedCrossRefGoogle Scholar
  26. 26.
    Takahashi M, Catterall WA (1987) Science 236:88–92PubMedCrossRefGoogle Scholar
  27. 27.
    Takahashi M, Catterall WA (1987) Biochemistry 26:5518–5526PubMedCrossRefGoogle Scholar
  28. 28.
    Curtis BM, Catterall WA (1986) Biochemistry 25:3077–3083PubMedCrossRefGoogle Scholar
  29. 29.
    Catterall WA (1986) Ann Rev Biochem 55:953–985PubMedCrossRefGoogle Scholar
  30. 30.
    Tanabe T, Takeshima H, Mikami A, Flockerzi V, Takahashi H, Kangawa K, Kojima M, Matsuo H, Hirose T, Numa S (1987) Nature 328:313–318PubMedCrossRefGoogle Scholar
  31. 31.
    Noda M, Ikeda T, Suzuki H, Takeshima H, Takahashi T, Kuno M, Numa S (1986) Nature 322:826–828PubMedCrossRefGoogle Scholar
  32. 32.
    Goldin AL, Snutch T, Lubbert H, Dowsett A, Marshall J, Auld V, Downey W, Fritz LC, Lester HA, Dunn R, Catterall WA, Davidson N (1986) Proc Natl Acad Sci USA 83:7503–7509PubMedCrossRefGoogle Scholar
  33. 33.
    Reber BFX, Catterall WA (1987) J Biol Chern, in pressGoogle Scholar
  34. 34.
    Seagar MJ, Labbe-Julle C, Granier C, Goll A, Glossmann H, Van Reitschoten J, Couraud F (1986) Biochemistry 25:4051–4057PubMedCrossRefGoogle Scholar
  35. 35.
    Horne WA, Weiland GA, Oswald RE (1986) J Biol Chern 261:3588–3594Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. J. Seagar
    • 1
  • M. Takahashi
    • 1
  • W. A. Catterall
    • 1
  1. 1.Department of PharmacologyUniversity of WashingtonSeattleUSA

Personalised recommendations