The Isolation and Characterization of Two Cytotoxic T-Lymphocyte-Specific Serine Protease Genes
The search for the molecules involved in cytotoxic T-cell-mediated lysis has been primarily conducted using two approaches. The first of these was immunological, in which potentially relevant molecules were identified by antibodies that interfered with lysis. Such studies suggested the involvement of a number of cell surface molecules in the process but largely their roles appeared to be at the level of target cell binding (Martz et al. 1983). Secondly, classical protein biochemistry was used to search for lytic components, resulting in the isolation of a number of potential candidates that are discussed elsewhere in this book. Although both lines of research have provided useful information, the identities and roles of many of the molecules involved remain a mystery.
KeywordsSerine Protease Cytoplasmic Granule Granular Component Serine Esterase Serine Protease Gene
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