The Structure and Function of Ca+2 - and Phospholipid- Dependent Protein Kinase (Protein Kinase C), A Trans-Membrane Signal Transducer

  • C. W. Mahoney
  • A. Azzi


Ca+2- and phospholipid- dependent protein kinase (protein kinase c), first discovered by Nishizuka’s group as a protease-activated kinase in 1977 (Takai et al., 1977 ; Inoue et al., 1977), has generated tremendous interest in the biochemical community in the last 11 years because of its implication in numerous biological processes including tumor promotion (Hecker & Schmidt, 1979), membrane transporter and channel modulation (Sigel et al., 1988 ; Costa & Catterall, 1985 ; Liles et al., 1986 ; Witters et al., 1985), differentiation (Morin et al., 1987 ; Pahlman et al., 1983), muscle contraction (Ikeba et al., 1985 ; Nishikawa et al., 1984 & 1985), neural synaptic communication (Tanaka et al., 1986), secretion (Ieyasu et al., 1982 ; Kajikawa et al., 1983), the respiratory burst (Mahoney & Azzi, in press, 1988 ; Lüthy & Azzi, 1987 ; Mahoney et al., 1986 ; Serhan et al., 1983 ; Fujita et al., 1984), the immune response (Patel et al., 1987), growth (Cooper et al., 1982 ; Cochet et al., 1984 ; McCaffrey et al., 1984 ; Davis & Czech, 1985) and platelet aggregation (Froscio et al., 1988 ; Mahoney & Azzi, in press ; Naka et al., 1983 ; Sano et al., 1983 ; Watson et al., 1988 ; Mahoney et al., this volume) (for reviews see Nishizuka 1984 & 1986).


Protein Kinase Phorbol Ester Dependent Protein Kinase Regulatory Fragment Intact Platelet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used


protein kinase c




phorbol 12, 13 dibutyrate




apparent molecular weight




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© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • C. W. Mahoney
  • A. Azzi

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