Pathology of Parkinson’s Syndrome

  • K. Jellinger
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 88)

Abstract

Parkinson’s syndrome or parkinsonism, involving the clinical symptoms first described by James Parkinson (1817) occurs in a variety of disorders of the central nervous system (CNS), basically characterized by dysfunction of the dopaminergic nigrostriatal system. It may or, rarely, may not be associated with distinct anatomic damage to the melanin-containing neurons of the substantia nigra, changes to the neuronal cytoskeleton, including the Lewy bodies, and pathology in other non-nigral neuronal systems, often as part of a more widespread process. The term Parkinson’s disease (PD) is restricted to paralysis agitans, the idiopathic form of parkinsonism associated with formation of Lewy bodies and loss of neurons in the pars compacta of the substantia nigra, known since TréTiakoff (1919) as the principal at-risk system in this disorder. It can be accompanied by nonspecific or age-related brain pathology and a variety of other coincidental lesions elsewhere in the CNS. Unilateral parkinsonism is associated with predominant damage to the contralateral brain stem or substantia nigra (Blocq and Marinesco 1893; Lindenberg 1964; Martinez and Utterback 1973; Oppenheimer 1984), while only in exceptional cases of parkinsonism no morphological lesions of the substantia nigra can be found (Denny-Brown 1960; Leverenz and Sumi 1986; Morris et al. 1987). On the other hand, moderate or even considerable damage to the substantia nigra, e.g., in aged subjects or senile dementia of the Alzheimer type (SDAT), may not be necessarily associated with parkinsonian symptoms (Hakim and Mathieson 1979; Jacob 1983; Heilig et al. 1985; Leverenz and Sukmi 1986; Jellinger 1987b; Ditter and Mirra 1987).

Keywords

Manganese Serotonin Catecholamine Ceru Statin 

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References

  1. Adams RD, Bogaert L van, Van der Eecken H (1964) Striato-nigral degeneration. Neuropathol Exp Neurol 23: 584–608Google Scholar
  2. Agid Y, Javoy-Agid F, Ruberg M, Pillon B, Bubous B (1986) Progressive supranuclear palsy: anatomoclinical and biochemical considerations. Adv Neurol 45: 101–206Google Scholar
  3. Agid Y, Javoy-Agid F, Ruberg M (1987) Biochemistry of neurotransmitters in Parkinson’s disease. In: Marsden CD, Fahii ST (eds) Movement disorders 2. Butterworths, London, pp 166–230Google Scholar
  4. Alafuzoff I, Iqbal K, Friden H, Adolfsson R, Winblad B (1987) Histopathological criteria for progressive dementia disorders: clinico-pathological correlation and classification by multivariate data analysis. Acta Neuropathol (Berl) 74: 204–225CrossRefGoogle Scholar
  5. Albert ML (1984) The controversy of subcortical dementia. Neurol Neurosurg Update Series 5: 2–8Google Scholar
  6. Alvord ED, Forno L, Kusske JA, Kaufmann BJ, Rhodes JS, Goetowski CR (1974) The pathology of parkinsonism. A comparison of degeneration in cerebral cortex and brainstem. Adv Neurol 5: 175–193PubMedGoogle Scholar
  7. Appel SH (1981) A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism and Alzheimer disease. Ann Neurol 10: 499–505PubMedCrossRefGoogle Scholar
  8. Arendt T, Bigl V, Arendt A, Tennstedt A (1983) Loss of neurons in the nucleus basalis of Meynert in Alzheimer’s disease, paralysis agitans and Korsakoff s disease. Acta Neuropathol (Berl) 61: 101–108CrossRefGoogle Scholar
  9. Arendt A, Bigl V, Tennstedt A (1985) Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical areas in Alzheimer’s disease. Neuroscience 14: 1–14PubMedCrossRefGoogle Scholar
  10. Arluison M, Dietl M, Thibault J (1984) Ultrastructural morphology of dopaminergic nerve terminals and synapses in the striatum of the rat using tyrosine hydroxylase immunocytochemistry. A topographical study. Brain Res Bull 13: 269–285PubMedCrossRefGoogle Scholar
  11. Ball MJ (1977) Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with aging and dementia. Acta Neuropathol (Berl) 37: 111–118CrossRefGoogle Scholar
  12. Ball MJ (1984) The morphological basis of dementia in Parkinson’s disease. Can J Neurol Sci 11: 180–184PubMedGoogle Scholar
  13. Bancher C, Lassmann H, Budka H, Grundke-Iqbal I, Iqbal K, Wiche G, Scitelberger F, Wisniewski HM (1987) Neurofibrillary tangles in Alzheimer’s disease and progressive supranuclear palsy: antigenic similarities and differences. Acta Neuropathol (Berl) 74: 39–46CrossRefGoogle Scholar
  14. Bancher C, Lassmann H, Budka H, Jellinger K, Grundke-Iqubal I, Iqbal K, Wiche G, Scitelberger F, Wisniewski HM (1989) Antigenic profile of Lewy bodies: immunocytochemical evidence for protein phosphorylation and ubiquitation. J Neuropathol Exp Neurol 48: (in press)Google Scholar
  15. Barbeau A (1984) Manganese and extrapyramidal disorders. Neurotoxicology (Park Forest II) 5: 13–36Google Scholar
  16. Barbeau A (1986) Parkinson’s disease: clinical features and etiopathology. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of clinical neurology, vol 5 (49). Elsevier, Amsterdam, pp 87–152Google Scholar
  17. Beal MF, Mazwak MF, Sevendsen CN et al. (1986) Widespread reduction of somatostatin-like immunoreactivity in cerebral cortex in Alzheimer’s disease. Ann Neurol 20: 489–495PubMedCrossRefGoogle Scholar
  18. Beheim-Schwarzbach D (1952) Über Zelleib-Veränderungen im Nucleus coeruleus bei Parkinson-Symptomen. J Nerv Ment Dis 116: 619–627PubMedCrossRefGoogle Scholar
  19. Bender MB (1980) Brain control of conjugate horizontal and vertical eye movements. Brain 103: 25–69CrossRefGoogle Scholar
  20. Benno RH, Tucker LW, Joh TH, Reis DJ (1982) Quantitative immunocytochemistry of tyrosine hydroxylase in rat brain. Brain Res 246: 225–236PubMedCrossRefGoogle Scholar
  21. Berciano J (1982) Olivopontocerebellar atrophy. A review of 117 cases. J Neurol Sci 53: 253–272PubMedCrossRefGoogle Scholar
  22. Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Scitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington. J Neurol Sci 20: 415–455PubMedCrossRefGoogle Scholar
  23. Birkmayer W, Riederer P (1985) Die Parkinson-Krankheit, 2nd edn. Springer, Vienna, New YorkGoogle Scholar
  24. Blackwood W (1981) Morbid anatomy. In: Rose FC, Capildeo R (eds) Research progress in Parkinson’s disease. Pitman, London, pp 25–31Google Scholar
  25. Blocq P, Marinesco G (1893) Sur un cas de tremblement parkinsonien hémiplégique symptomatique d’une tumeur du pédoncule cérébral. C R Soc Biol (Paris) 45: 105Google Scholar
  26. Bogerts B, Häntsch J, Herzer M (1983) A morphometric study of the dopamin-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics. Biol Psychiatry 18: 951–969PubMedGoogle Scholar
  27. Boller F (1985) Parkinson’s disease and Alzheimer’s disease: are they associated? In: Senile dementia of the Alzheimer type. Liss, New York, pp 119–129Google Scholar
  28. Boller F, Mizutani T, Roessmann U, Gambetti P (1979) Parkinson’s disease, dementia and Alzheimer disease: clinicopathological correlations. Ann Neurol 7: 329–335CrossRefGoogle Scholar
  29. Bondareff N, Mountjoy CQ, Roth M (1982) Loss of neurons of origin of the adrenergic projections to the cerebral cortex (nucleus locus coeruleus) in senile dementia. Neurology (NY) 32: 165–168Google Scholar
  30. Borit A, Rubinstein LJ, Urich H (1975) The striatonigral degeneration—putaminal pigments and nosology. Brain 98: 101–112PubMedCrossRefGoogle Scholar
  31. Böttcher J (1975) Morphology of the basal ganglia in Parkinson’s disease. Acta Neurol Scand 52 (Suppl 62): 1–160Google Scholar
  32. Brodal A (1981) Neurological anatomy in relation to clinical medicine, 3rd edn. Oxford University Press, New York, pp 411–416Google Scholar
  33. Bugiani O, Perdelli F, Salvarini S, Leonardi A, Mancardi GL (1980) Loss of striatal neurons in Parkinson’s disease: a cytometric study. Eur Neurol 19: 339–344PubMedCrossRefGoogle Scholar
  34. Burkhardt C, Filley CM, Kleinschmidt-De Masters BK, de la Monte S, Norenberg MD, Schneck SA (1988) Diffuse Lewy body disease and progressive dementia. Neurology 38: 1520–1528Google Scholar
  35. Buttlar-Brentano K von (1955) Das Parkinsonsyndrom im Lichte der lebensgeschichtlichen Veränderungen des Nucleus basalis. J Hirnforsch 2: 55–76Google Scholar
  36. Byrne EJ, Lowe J, Godwin-Austin RB, Aire T, Jones R (1987) Dementia and Parkinson’s disease associated with diffuse cortical Lewy bodies. Lancet 1: 501PubMedCrossRefGoogle Scholar
  37. Candy JM, Perry RH, Perry EK, Irving D, Blessed G, Fairbairn AF, Tomlinson BE (1983) Pathological changes in the nucleus of Meynert in Alzheimer’s and Parkinson’s disease. J Neurol Sci 54: 277–289CrossRefGoogle Scholar
  38. Candy JM, Perry EK, Perry RH, Court JA, Oakley AE, Edwardson JA (1986) The current status of the cortical cholinergic system in Alzheimer’s disease and Parkinson’s disease. In: Swaab DF, Fliers E, Mirmirian M, Van Gool WA, Van Hagren F (eds) Aging of the brain and Alzheimer’s disease. Progress in brain research, vol 70. Elsevier Scientific, Amsterdam, pp 105–1322CrossRefGoogle Scholar
  39. Carmichael SW, Wilson RJ, Brimijoin WS et al. (1988) Decreased catecholamine levels in the adrenal medulla of patients with Parkinson’s disease. New Engl J Med 319: 254–256Google Scholar
  40. Carpenter MB (1986) Anatomy of the basal ganglia. In: Vinken PJ, Bruyn GW, Klawans HL (eds). Handbook of clinical neurology, vol5 ( 49 ): Elsevier Scientific, Amsterdam—New York: pp 1–18Google Scholar
  41. Cash R, Dennis R, L’Heureux R, Raisman R, Javoy-Agid F, Scatton B (1987) Parkinson’s disease and dementia: norepinephrine and dopamine in locus ceruleus. Neurology 37: 42–46PubMedGoogle Scholar
  42. Chen K-M, Chase TN (1986) Parkinson-dementia. In: Vinken PJ, Bruyn GW, Klawans HL (1986) Handbook of clinical neurology, vol 5 ( 49 ). Elsevier Scientific, Amsterdam—New York pp 167–183Google Scholar
  43. Chiueh CC, Burns RS, Markey SP, Jacokobowitz DM, Kopin IJ (1985) Primate model of parkinsonism: selective lesion of nigrostriatal neurons by l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys. Life Sci 36: 213–218PubMedCrossRefGoogle Scholar
  44. Christensen E, Möller JE, Faurbye A (1970) Neuropathological investigation of 28 brains from patients with dyskinesias. Acta Psychiatr Scand 46: 14–23PubMedCrossRefGoogle Scholar
  45. Chui HC, Mortimer JA, Slager U, Barrow C, Bondareff W, Webster DD (1986) Pathological correlates of dementia in Parkinson’s disease. Arch Neurol 43: 991–995PubMedCrossRefGoogle Scholar
  46. Clark AW, Lehmann J (1983) Dementia with widespread Lewy bodies. Studies of the neocortical cholinergic system (abstr). Canadian Association of Neuropathology, 23rd Annu Meeting, Sept 29–30, 1983Google Scholar
  47. Clark AW, Sternberger NH, Parhad IM, Sima AAF, Sternberger LA (1986) Immunoreactivity of Lewy bodies with monoclonal antibodies to neurofilament epitopes (abstr). J Neuropathol Exp Neurol 45: 333CrossRefGoogle Scholar
  48. Constantinidis J, Bouras C, Richard J (1983) Putative neurotransmitters in human neuropathology; a review of topography and clinical implications. Clin Neuropathol 2: 47–54PubMedGoogle Scholar
  49. Corin MS, Elizan TS, Bender MB (1972) Oculomotor function in patients with Parkinson’s disease. J Neurol Sci 15: 251–265PubMedCrossRefGoogle Scholar
  50. Corsellis JAN, Bruton CJ, Freeman-Browne D (1973)The aftermath of boxing. Psychol Med 3: 270–303Google Scholar
  51. Coyle JT, Price D, De Long MR (1983) Alzheimer’s disease: a disorder of cortical cholinergic innervation. Science 219: 1184–1190PubMedCrossRefGoogle Scholar
  52. Critchley M (1929) Arteriosclerotic parkinsonism. Brain 52: 23–83CrossRefGoogle Scholar
  53. Crossman AR, Clarke CE, Boyce S et al. (1988). MPTP-incuded parkinsonism in the monkey. Can J Neurol Sci 14: 428–435Google Scholar
  54. Crystal HA, Dickson D, Fuld P, Maseu J, Grober E, Aronson M, Wolfson L, Goldman J (1987) Association between senile plaque count and cognitive status in dementia and normal aging (abstr). Neurology 37 (Suppl 1): 226Google Scholar
  55. Cummings JL (1986) Subcortical dementia: neuropsychology, neuropsychiatry, and pathophysiology. Brit J Psychiatr 149: 682–697CrossRefGoogle Scholar
  56. Curcio CA, Kemper T (1984) Nucleus raphe dorsalis in dementia of the Alzheimer type: neurofibrillary changes and neuronal packing density. J Neuropathol Exp Neurol 43: 359–368PubMedCrossRefGoogle Scholar
  57. Davies P (1983) Neurotransmitters and neuropeptides in Alzheimer’s disease. In: Katzman R (ed) Biological aspects of Alzheimer’s disease, Banbury report vol 15. Cold Spring Harbor, New York, pp 255–261Google Scholar
  58. Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert DM, Kopin IJH (1979) Chronic parkinsonism secondary to intravenous injection of meperidine analogues. Psychiat Res 1: 249–254CrossRefGoogle Scholar
  59. Davison CH (1954) Pallido-pyramidal disease. J Neuropathol Exp Neurol 13: 50–59PubMedCrossRefGoogle Scholar
  60. Dekaban AS (1978) Changes in brain weights during the span of human life. Ann Neurol 4: 345–356PubMedCrossRefGoogle Scholar
  61. Delisle MN, Gorce P, Hirsch E, Hauw JJ, Boissou H, Rascol A (1987) Motor neuron disease, parkinsonism and dementia. Report of a case with diffuse Lewy body-like intracytoplasmic inclusions. Acta Neuropathol (Berl) 75: 104–108CrossRefGoogle Scholar
  62. De Morsier G (1960) Parkinsonism consécutif à une lésion traumatique du noyau rouge et du locus niger. Psychiatr Neurol (Basel) 139: 60–84CrossRefGoogle Scholar
  63. Denny-Brown D (1960) Diseases of the basal ganglia; their relations to disorders of movement. Lancet 11: 1099–1101CrossRefGoogle Scholar
  64. Descarries L, Watkins EC, Garcia S, Beaudet A (1982) The serotonin neurons in nucleus raphe dorsalis of adult rats: a light and electron microscopic radioautographic study. J Comp Neurol 297: 239–254CrossRefGoogle Scholar
  65. De Smedt Y, Ruberg M, Serdarn M, Dubois B, Agid J (1982) Confusion, dementia and anticholinergics in Parkinson’s disease. J Neurol Neurosurg Psychiatry 45: 1161–1164CrossRefGoogle Scholar
  66. Dickson DW, Kress Y, Crowe A, Yen SH (1985) Monoclonal antibodies to Alzheimer neurofibrillary tangles (ANT). 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degenerative supranuclear palsy. Am J Pathol 120: 292–303PubMedGoogle Scholar
  67. Dickson DW, Davies P, Mayeux R, Crystal H, Horoupian DS, Thompson A, Goldman JE (1987 a) Diffuse Lewy body disease: neuropathological and biochemical studies of six patients. Acta Neuropathol (Berl) 75: 1–7Google Scholar
  68. Dickson DW, Kszeizak-Reding H, Davies P, Yen SH (1987 b) A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration. Acta Neuropathol (Berl) 73: 254–258Google Scholar
  69. Dietl M (1985) Etude immuncytochimique de la cholecystokinine et la tyrosine hydroxylase dans la moelle épiniére chez le rat et chez l’homme. Thesis Univ Paris.Google Scholar
  70. Ditter SM, Mirra S S (1987) Neuropathologic and clinical features of Parkinson’s disease in Alzheimer disease patients. Neurology 37: 754–760PubMedGoogle Scholar
  71. Doucette R, Fisman M, Hachinski VC, Mersky H (1986) Cell loss from the nucleus basalis of Meynert in Alzheimer disease. Can J Neurol Sci 13: 435–440PubMedGoogle Scholar
  72. Drayer BP, Olanow W, Burger P, Johnson GA, Herfkens R, Riederer P (1986) Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. Radiology 159: 493–498PubMedGoogle Scholar
  73. Dubinsky RM, Jankovic J (1987) Progressive supranuclear palsy and a multi-infarct state. Neurology 37: 570–576PubMedGoogle Scholar
  74. Dubois B, Hauw JJ, Ruberg M, Serdaru M, Javoy-Agid F, Agid Y (1985) Dementia and Parkinson’s disease: biochemical and clinico-pathological correlations. Rev Neurol (Paris) 141: 184–193Google Scholar
  75. Duffy P (1972) Discussion. Neurology (Minneap) 22 (Suppl II): 66–67Google Scholar
  76. Duffy P, Tennyson VM (1965) Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson’s disease. J Neuropathol Exp Neurol 24: 398–414CrossRefGoogle Scholar
  77. Duvoisin RC (1987) The olivopontocerebellar atrophies. In: Marsden CD, Fahn ST (eds) Movement disorders 2. Butterworths, London, pp 249–269Google Scholar
  78. Eadie MJ, Sutherland JM (1964) Arteriosclerosis in parkinsonism. J Neurol Neurosurg Psychiatry 27: 237–240PubMedCrossRefGoogle Scholar
  79. Earle KM (1968) Studies on Parkinson’s disease including X-ray fluorescent spectroscopy of formalia fixed brain tissue. J Neuropathol Exp Neurol 27: 1–14PubMedCrossRefGoogle Scholar
  80. Eggerstron DE, Sima AAF (1986) Dementia with cerebral Lewy bodies. A mesocortical dopaminergic deficit? Arch Neurol 43: 524–527CrossRefGoogle Scholar
  81. Elizan TS, Sroka M, Maker H, Smith M, Yahr MD (1986) Dementia in idiopathic Parkinson’s disease. Variables associated with its occurrence in 203 patients. J Neural Transm 65: 285–302PubMedCrossRefGoogle Scholar
  82. Epelbaum J, Ruberg M, Moyse E, Javoy-Agid F, Dubois B, Agid Y (1986) Somatostatin in Parkinson’s disease. Brain Res 278: 376–397CrossRefGoogle Scholar
  83. Escourolle R, Recodo J de, Gray F (1971) Etude anatomo-pathologique des syndromes parkinsonism. In: Ajuriaguerra J, Gauthier G (eds) Monoamines et noyaux gris centraux. Masson, Geneve, pp 173–229Google Scholar
  84. Etienne P, Robitaille Y, Wood P, Gauthier S, Nair NPV, Quirion R (1986) Nucleus basalis neuronal loss, neuritic plaques and choline acetyl-transferase activity in advances Alzheimer’s disease. Neuroscience 19: 1279–1291PubMedCrossRefGoogle Scholar
  85. Ezrin-Waters C, Resch L (1986) The nucleus basalis of Meynert. Can J Neurol Sci 13: 8–14PubMedGoogle Scholar
  86. Fahn ST (1977) Secondary parkinsonism. In: Goldensohn ES, Appel SH (eds) Scientific approaches to clinical neurology. Lee and Febiger, Philadelphia, pp 1159–1189Google Scholar
  87. Fahn S, Libsch LR, Cutler RMA Monoamines in the human neostriatum: topographic distribution in normals und in Parkinson’s disease and their role in akinesia, rigiditgy, chorea, and tremor. J Neurol Sci 14: 427–455.Google Scholar
  88. Ferrante RJ, Kowall WW, Marint JB, Richardson EP (1985) Characteristics of a selectively spared subset of neurons in Huntington’s chorea (abstr). J Neuropathol Exp Neurol 44: 325CrossRefGoogle Scholar
  89. Fischer PA (ed) (1984) Parkinson plus. Zerebrale Polypathie beim Parkinson-Syndrom. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  90. Fishman EB, Siek GC, MacCallum RD, Bird ED (1986) Distribution of the molecular forms of acetylcholinesterase in human brain: alterations in dementia. Ann Neurol 19: 246–252PubMedCrossRefGoogle Scholar
  91. Foix C, Nicolesco J (1925): Les noyaux gris centraux et la région mésencéphalosous-optique. Masson, Paris Forno LS (1966) Pathology of parkinsonism. J Neurosurg Suppl 11: 266–271.Google Scholar
  92. Forno LS (1969) Concentric hyaline intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases); relationship in parkinsonism. J Am Geriatr Soc 17: 557–575PubMedGoogle Scholar
  93. Forno LS (1982) Pathology of Parkinson’s disease. In: Marsden CD, Gahn S (eds) Movement disorders. Butterworths, London, pp 25–30Google Scholar
  94. Forno LS (1986) The Lewy body in Parkinson’s disease. Adv Neurol 45: 35–43Google Scholar
  95. Forno LS, Alvord EC (1971) The pathology of parkinsonism. In: Markham CH (eds) Recent advances in Parkinson’s disease. Davis, Philadelphia, pp 120–130Google Scholar
  96. Forno LS, Norville RL (1981) Synaptic morphology in the human locus coeruleus. Acta Neuropathol (Berl) 53: 7–14CrossRefGoogle Scholar
  97. Forno LS, Barbour PJ, Norville RL (1978) Presenile dementia with Lewy bodies and neurofibrillary tangles. Arch Neurol 35: 816–822CrossRefGoogle Scholar
  98. Forno LS, Sternberger NR, Eng LF (1983) Immunocytochemical staining of neurofibrillary tangles and of the periphery of Lewy bodies with a monoclonal antibody to neurofilaments (abstr). J Neuropathol Exp Neurol 42: 342CrossRefGoogle Scholar
  99. Forno LS, Gardiner RE, Eng LF (1985 a) Somatostatin-like immunoreactivity in the human basal ganglia (abstr). J Neuropathol Exp Neurol 44: 326Google Scholar
  100. Forno LS, Sternberger LA, Sternberger NH, Strefling AM et al. (1985 b) Reaction of Lewy bodies with antibodies to phosphorylated and non-phosphorylated neurofilaments. Neurosci Lett 64: 253–258Google Scholar
  101. Forno LS, Langston JW, DeLanney LE, Irwin I, Ricaurte GA (1986) Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol 20: 449–455PubMedCrossRefGoogle Scholar
  102. Forno LS, Langston JW, DeLanney LE, Irwin I (1988) An electron microscopic study of MPTP-induced inclusion bodies in an old monkey. Brain Res 448: 150–157PubMedCrossRefGoogle Scholar
  103. Friedman A, Kang UJ, Tatemichi TK, Burke RE (1986) A case of parkinsonism following striatal lacunar infarction. J Neurol Neurosurg Psychiatry 49: 1087–1088PubMedCrossRefGoogle Scholar
  104. Fujimura M, Umbach J (1987) Pathological considerations between dementia, Parkinson’s disease and lesions of the reticular formation. Rev Neurol (Paris) 143: 108–114Google Scholar
  105. Gage FH, Bjorklund A, Isacson O, Brundin P (1986) Uses of neuronal transplantation in models of neurodegenerative disease. In: Das GD, Wallace RB (eds) Neural transplantation and regeneration proceedings in life sciences. Springer, Berlin Heidelberg New York Tokyo, pp 103–124CrossRefGoogle Scholar
  106. Galloway P, Perry G, Grundke-Iqbal I, Antili-Gambetti L, Gambetti P (1986) Lewy bodies share epitopes with neurofilaments, tubulin, and neurofibrillary tangles (abstr) Proc 10th Int Congr Neuropath, Stockholm, p 298Google Scholar
  107. Galloway PG, Perry G, Gambetti P (1987) Hirano body filaments contain actin and actin-associated proteins. J Neuropathol Exp Neurol 46: 185–199PubMedCrossRefGoogle Scholar
  108. Galloway PG, Grundke-Iqbal I, Iqbal K, Perry G (1988) Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles. J Neuropathol Exp Neurol 47: 654–663PubMedCrossRefGoogle Scholar
  109. Gamboa ET, Wolf A, Yahr MD et al. (1974) Influenza virus antigen in postencephalitic parkinsonism brain. Detection by immunofluorescence. Arch Neurol 31: 228–232PubMedCrossRefGoogle Scholar
  110. Garcia de Yebenes J, Gervas J J, Iglesias J, Menaj et al. (1982) Biochemical finding in a case of parkinsonism secondary to brain tumor. Ann Neurol 11: 313–316Google Scholar
  111. Gaspar P, Gray F (1984) Dementia in idiopathic Parkinson’s disease. A neuropathological study of 32 cases. Acta Neuropathol (Berl) 64: 43–52CrossRefGoogle Scholar
  112. Gherardi R, Roudes B, Fleury J, Probst C et al. (1985) Parkinsonian syndrome and central nervous system lymphoma involving the substantia nigra. Acta Neuropathol (Berl) 65: 338–343CrossRefGoogle Scholar
  113. Gibb WRG (1986) Idiopathic Parkinson’s disease and the Lewy body disorders. Neuropathol Appl Neurobiol 12: 223–234PubMedCrossRefGoogle Scholar
  114. Gibb WRG (1988) The neuropathology of parkinsonian disorders. In: Jankovic J, Tolowa E (eds): Parkinson’s disease and movement disorders. Baltimore—Munich: Urban & Schwarzenberg, pp 205–223Google Scholar
  115. Gibb WRG, Lees AJ (1987) The progression of idiopathic Parkinson’s disease is not explained by age-related changes. Clinical and pathological comparisons with post-encephalitic parkinsonian syndrome. Acta Neuropathol (Berl) 73: 195–201CrossRefGoogle Scholar
  116. Gibb WRG, Lees AJ (1988) A comparison of clinical and pathological features of young- and old-onset Parkinson’s disease. Neurology 38: 1402–1406PubMedGoogle Scholar
  117. Gibson PH (1978) Light and electron microscopic observations on the relationship between Hirano bodies, neuron and glial perikarya in the human hippocampus. Acta Neuropathol (Berl) 42: 165–171CrossRefGoogle Scholar
  118. Gibson PH (1983) Form and distribution of senile plaque in silver impregnation sections in the brains of intellectually normal elderly people and people with Alzheimer-type dementia. Neuropathol Appl Neurobiol 9: 379–389PubMedCrossRefGoogle Scholar
  119. Goldman JE, Yon SH, Chiu FC, Peress NS (1983) Lewy bodies of Parkinson’s disease contain neurofilament antigens. Science 221: 1082–1084PubMedCrossRefGoogle Scholar
  120. Gräfe MR, Forno LS, Eng LF (1983) Substance P and metenkephalin immunoreactivity in Parkinson’s Huntington’s and Alzheimer’s disease (abstr). J Neuropathol Exp Neurol 42: 345CrossRefGoogle Scholar
  121. Gray F (1988) Neuropathologie des syndromes parkinsoniens. Rev Neurol (Paris) 144: 229–248Google Scholar
  122. Graybiel AM (1984) Neurochemically specified subsystems in the basal ganglia. In: Functions of the basal ganglia. Ciba Found Symp 107: 114–144Google Scholar
  123. Graybiel AM (1986) Neuropeptides in the basal ganglia. In: Martin JB, Barchas J (eds). Neuropeptides in neurologic and psychiatric disease. Raven, New York, pp 135–161Google Scholar
  124. Greenfield JG, Bosanquet FD (1953) The brainstem lesions in parkinsonism. J Neurol Neurosurg Psychiatry 16: 213–226PubMedCrossRefGoogle Scholar
  125. Grilia M, Henin D, Sazdovitch Y, Hauw JJ (1987) Clinicopathological correlation in 222 cases of parkinsonism syndrome (abstr). Neuropathol Appl Neurobiol 13: 614Google Scholar
  126. Growdon JH, Corkin S (1986) Cognitive impairment in Parkinson’s disease. Adv Neurol 45: 383–392Google Scholar
  127. Guiloff RJ, George RJ, Marsden CD (1980) Reversible supranuclear ophthalmoplegia associated with parkinsonism. J Neurol Neurosurg Psychiatry 43: 352–354Google Scholar
  128. Guttman M, Calne DB (1988) In vivo characterization of cerebral dopamine systems in human parkinsonism. In: Jankovic J, Tolosa E (eds) Parkinsons’ disease and movement disorders. Urban & Schwarzenberg: Baltimore—Munich, pp 49–58Google Scholar
  129. Hakim AM, Mathieson G (1979) Dementia in Parkinson disease: a neuropathology study. Neurology (NY) 20: 1209–1214Google Scholar
  130. Hallervorden J (1957) Paralysis agitans. In: Scholz W (ed) Handbuch der speziellen pathologischen Anatomie und Histologie, vol XIII/1A. Springer, Berlin Göttingen Heidelberg, pp 900–924Google Scholar
  131. Hartog-Jager WA (1969) Sphingomyelin in Lewy inclusion bodies in Parkinson’s disease. Arch Neurol 21: 615–619CrossRefGoogle Scholar
  132. Hartog-Jager WA, Bethlem J (1960) The distribution of Lewy bodies in the central and autonomic systems in idiopathy paralysis agitans. J Neurol Neurosurg Psychiatry 23: 283–290CrossRefGoogle Scholar
  133. Hassler R (1938) Zur Pathologie der Paralyse agitans und des postenzephalitischen Parkinsonism. J Psychol Neurol (Lpz) 48: 387–476Google Scholar
  134. Hassler R (1965) Extrapyramidal control of the speed of behaviour and its change by primary age processes. In: Welford AT, Birren JK (eds). Behavior, aging and the nervous System. Thomas, Springfield, pp 284–306Google Scholar
  135. Hedreen JC, Struble RG, Whitehouse PJ, Price DL (1984) Topography of the magnocellular basal forebrain system in human brain. J Neuropathol Exp Neurol 43: 1–21PubMedCrossRefGoogle Scholar
  136. Hefti F, Melamed E, Bhawan J, Wurtman RJ (1981) Long-term administration of L-dopa does not damage dopaminergic neurons in the mouse. Neurology (NY) 31: 1194–1195Google Scholar
  137. Heilig CW, Knopman DS, Mastri AR, Frey W (1985) Dementia without Alzheimer pathology. Neurology 35: 762–765PubMedGoogle Scholar
  138. Henderson Z (1987) A small proportion of cholinergic neurones in the nucleus basalis magnocellularis of ferret appear to stain positively for tyrosine hydroxylase. Brain Res 412: 363–369PubMedCrossRefGoogle Scholar
  139. Henderson Z, Greenfield SA (1987) Does the substantia nigra have cholinergic innervation? Neurosci Lett 73: 109–113PubMedCrossRefGoogle Scholar
  140. Heston LL (1981) Genetic studies of dementia. In: Mortimer A, Schulman LM (eds) Epidemiology of dementia. Oxford University Press, New York, pp 101–114Google Scholar
  141. Hirano A (1981) A guide to neuropathology. Igaku-Shoin. Tokyo New York Hirano A, Malamud N, Elisan TS, Kurland LT (1966) Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam. Further pathologic studies. Arch Neurol 15: 35–51Google Scholar
  142. Hirano A, Zimmerman HM (1962) Alzheimer’s neurofibrillary changes: a topographic study. Arch Neurol 7: 227–242PubMedCrossRefGoogle Scholar
  143. Hirano A, Malamud N, Kurland LT (1981) Parkinsonism-dementia complex, an endemic disease on the island of Guam. II.—Pathological features. Brain 84: 662–679CrossRefGoogle Scholar
  144. Hirano A, Llena J (1986) Neuropathological features of Parkinsonism dementia complex of Guam: reapraisal and comparative study with Alzheimer’s disease and Parkinson’s disease. Prog Neuropathol 6: 17–31Google Scholar
  145. Hirsch E, Ruberg M, Dardenne M, Portier MM, Javoy-Agid F, Bach JF, Agic Y (1985) Monoclonal antibodies raised against Lewy bodies in brains from subjects with Parkinson’s disease. Brain Res 345: 374–378PubMedCrossRefGoogle Scholar
  146. Hirsch EC, Graybiel AM, Duyckaerts C, Javoy-Agid F (1987) Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson’s disease and progressive supranuclear palsy. Proc Nat Acad Sci USA 84: 5976–5981PubMedCrossRefGoogle Scholar
  147. Hirsch E, Graybiel AM, Agid YA (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson’s disease. Nature 334: 345–348PubMedCrossRefGoogle Scholar
  148. Ho KC, Roessmann U, Straumfjord JV, Monroe G (1980) Analysis of brain weight. Pathol Lab Med 104: 635–639Google Scholar
  149. Hornykiewicz O (1982) Brain neurotransmitter changes in Parkinson’s disease. In: Marsden CD, Fahn S (eds) Movement disorders. Butterworth, London, pp 41–58Google Scholar
  150. Hornykiewicz O, Kish SJ (1984) Neurochemical basis of dementia in Parkinson’s disease. Can J Neurol Sci 11: 185–190PubMedGoogle Scholar
  151. Hornykiewicz O, Kish SJ (1986) Biochemical pathophysiology of Parkinson’s disease. Adv Neurol 45: 19–34Google Scholar
  152. Hubbard BM, Anderson JM (1985) Age related variations in the neurone content of the cerebral cortex in senile dementia of the Alzheimer type. Neuropathol Appl Neurobiol 11: 369–382PubMedCrossRefGoogle Scholar
  153. Huber SJ, Shuttleworth EC, Paulson GW (1986) Dementia in Parkinson’s disease. Arch Neurol 43: 987–990PubMedCrossRefGoogle Scholar
  154. Hudson AJ (1981) Amyotrophic lateral sclerosis and its association with dementia, parkinsonism, and other neurological disorders. A review. Brain 104: 217–247PubMedCrossRefGoogle Scholar
  155. Huhn B, Jakob H (1971) Traumatische Hirnstammläsionen mit vieljähriger Überlebensdauer. Beitrag zur Pathologie der Substantia nigra und der oralen Brückenhaube. Nervenarzt 41: 326–334Google Scholar
  156. Hunter S (1985) The rostral mesencephalon in Parkinson’s and Alzheimer’s disease. Acta Neuropathol (Berl) 68: 53–58CrossRefGoogle Scholar
  157. Hymann BT, vanHoesen GW, Damasio AR, Barned CL (1984) Alzheimer’s disease: cell specific pathology isolates the hippocampal formation. Science 225: 1168–1170CrossRefGoogle Scholar
  158. Ichimija Y, Arai H, Kosaka K, Iizuka R (1986) Morphological and biochemical changes in the cholinergic and monoaminergic system in Alzheimer-type dementia. Acta Neuropathol (Berl) 70: 112–116CrossRefGoogle Scholar
  159. Iizuka R, Hirayama K (1986) Dentato-rubro-pallido-luysian atrophy. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of Clinical Neurology, vol. 5 ( 49 ) Elsevier Scientific, Amsterdam New York: pp 437–443Google Scholar
  160. Íkeda K, Ikeda S, Yoshimura T, Kato H, Namba M (1978) Idiopathic parkinsonism with Lewy-type inclusions in cerebral cortex. A case report. Acta Neuropathol (Berl) 41: 165–168CrossRefGoogle Scholar
  161. Ingram VM, Koenig JH, Miller CH, Moore HE, Blanchard B, Perry DE (1987) The locus coeruleus: computer assisted 3-dimensional analysis of degeneration in Alzheimer’s and Down’s disease. In: Wurtman RJ, Corkin SH, Growden JH (eds) Alzheimer’s disease: advances in basic research and therapy. Center for Brain Science and Metabolism Charitable Trust, Cambridge, pp 435–440.Google Scholar
  162. Ishii T (1966) Distribution of Alzheimer’s neurofibrillary tangles in the brainstem and hypothalamus in senile dementia. Acta Neuropathol (Berl) 6: 181–187CrossRefGoogle Scholar
  163. Ishii T, Nakamura Y (1981) Distribution and ultrastructure of Alzheimer’s neurofibrillary tangles in postencephalitic parkinsonism of Economo type. Acta Neuropathol (Berl) 55: 59–62CrossRefGoogle Scholar
  164. Jacob H (1983) Klinische Neuropathologie des Parkinsonism. In: Gänshirt H, Berlit P, Haack G (eds) Pathophysiologic, Klinik und Therapie des Parkinsonism. Roche, Basel, pp 5–18Google Scholar
  165. Jacobs RW, Butcher LL (1986) Pathology of the basal forebrain in Alzheimer’s disease and other dementias. In: Scheibel AB, Wechsler AF (eds) The biological substrates of Alzheimer’s disease. Academic, Orlando, pp 87–100Google Scholar
  166. Jamada M, Mehraein P (1968) Verteilungsmuster der senilen Veränderungen im Gehirn. Arch Psychiatr Nervenkr 211: 308–324PubMedCrossRefGoogle Scholar
  167. Jankovic J (1988) Neural transplants in the treatment of Parkinson’s disease and other neurodegenerative disorders. In: Jankovic J, Tolosa E (eds) Parkinson’s disease and movement disorders. Urban & Schwarzenberg: Baltimore—Munich, pp 471–480Google Scholar
  168. Jankovic J, Kirkpatrick JB, Blomquist KA, Langlais PJ, Bird ED (1985) Late-onset Hallervorden-Spatz disease presenting as familial parkinsonism. Neurology (NY) 35: 227–234Google Scholar
  169. Javoy-Agid F, Agid Y (1980) Is the mesocortical dopaminergic system involved in Parkinson’s disease? Neurology (NY) 30: 1326–1330Google Scholar
  170. Javoy-Agid F, Ploska A, Agid Y (1981) Microtopography of tyrosine hydroxylase, glutamic acid decarboxylase, and choline acetyltransferase in the sustantia nigra and ventral tegmental area of control and parkinsonian brain. J Neurochem 37: 1218–1227PubMedCrossRefGoogle Scholar
  171. Javoy-Agid F, Ruberg M, Taquer H, Bobobza B, Agid Y (1984) Biochemical neuropathology of Parkinson’s disease. Adv Neurol 40: 189–197PubMedGoogle Scholar
  172. Javoy-Agid F, Ruberg M, Hirsch E, Cash R, Raisman R, Taquet H, Epelbaum J, Scatton B, Duyckaerts C, Agid Y (1986) Recent progress in the neurochemistry of Parkinson’s disease. In: Fahn S, Marsden CD, Jenner P, Teychenne P (eds) Recent developments in Parkinson’s disease. Raven, New York, pp 67–83Google Scholar
  173. Jellinger K (1973) Neuroaxonal dystrophy: its natural history and related disorders. Prog Neuropathol 2: 129–180Google Scholar
  174. Jellinger K (1974) Pathomorphologie des Parkinson-Syndroms. Aktuelle Neurol 1: 83–98Google Scholar
  175. Jellinger K (1977) Neuropathologie findings after neuroleptic long-term therapy. In: Shiraki H, Grcevic N (eds) Neurotoxicology. Raven, New York, pp 25–42Google Scholar
  176. Jellinger K ( 1986 a) Pathology of parkinsonism. In: Fahn S, Marsden CD, Jenner P, Teychenne R (eds) Recent developments in parkinsonism. Raven, New York, pp 33–66Google Scholar
  177. Jellinger K (1986 b) Overview of morphological changes in Parkinson’s disease. Adv Neurol 45:1–18Google Scholar
  178. Jellinger K ( 1986 c) Pallidal, pallidonigral, pallidoluysionigral degenerations. In: Vincken P, Bruyn GW, Klawans W (eds) Handbook of clinical neurology, vol 49. Elsevier Scientific Amsterdam, New York pp 445–463Google Scholar
  179. Jellinger K ( 1987 a) The pathology of parkinsonism. In Marsden CD, Fahn S (eds) Movements disorders 2. Butterworths, London pp 124–165Google Scholar
  180. Jellinger K (1987 b) Neuropathological substrates of Alzheimer’s disease and Parkinson’s disease. J Neural Transm [Suppl]. 24:109–129Google Scholar
  181. Jellinger K (1987 c) Quantitative changes in some subcortical nuclei in aging, Alzheimer’s disease and Parkinson’s disease. Neurobiol Aging 8: 556–561Google Scholar
  182. Jellinger K (1987 d) Pathologic correlates of dementia in Parkinson’s disease. Arch Neurol 44:692Google Scholar
  183. Jellinger K (1988) The pedunculopontine nucleus in Parkinson’s disease, supranuclear palsy and Alzheimer’s disease. J Neurol Neurosurg. Psychiat 51: 540–544PubMedCrossRefGoogle Scholar
  184. Jellinger K (1989) Morphologie des alternden Gehirns und der (prä)senilen Demenzen. In: Platt D, Oesterreich K (eds) Handbuch der Gerontologie, vol 5. Fischer, StuttgartGoogle Scholar
  185. Jellinger K, Riederer P (1984) Dementia in Parkinson’s disease and (pre)senile dementia of Alzheimer type: morphological aspects and changes in the intracerebral MAO activity. Adv Neurol 40: 199–210PubMedGoogle Scholar
  186. Jellinger K, Riederer P, Tomonaga M (1980) Progressive supranuclear palsy: clinico-pathological and biochemical studies. J Neural Transm 16: 111–128Google Scholar
  187. Jorgensen OS, Reynolds GP, Riederer P, Jellinger K (1982) Parkinson’s disease putamen: normal concentration of synaptic membrane marker antigens. J Neural Transm 54: 171–179PubMedCrossRefGoogle Scholar
  188. Joynt RJ, McNeill TH (1984) Neuropeptides in aging and dementia. Peptides (Fayetteville) 5 (Suppl 1): 269–274CrossRefGoogle Scholar
  189. Kahn J, Anderton BH, Gibb WRG, Lees FR, Wells CD, Marsden D (1985) Neuronal filaments in Alzheimer’s Pick’s and Parkinson’s diseases. N Engl J Med 313: 520–521PubMedCrossRefGoogle Scholar
  190. Kato T, Hirano A, Winberg MN, Jacobs AK (1986) Spinal cord lesions in progressive supranuclear palsy: some new observations. Acta Neuropathol (Berl) 71: 11–14CrossRefGoogle Scholar
  191. Katzman R (1986) Alzheimer’s disease. N Engl J Med 324:964–972CrossRefGoogle Scholar
  192. Khachaturian ZS (1975) Diagnosis of Alzheimer’s disease. Arch Neurol 42: 1097–1105Google Scholar
  193. Kidd M (1964) Alzheimer’s disease. An electron microscopic study. Brain 87: 307–320PubMedCrossRefGoogle Scholar
  194. Kimula Y, Utsuyama M, Yoshimura M, Tomonaga M (1983) Element analysis of Lewy and adrenal bodies in Parkinson’s disease by electron probe microanalysis. Acta Neuropathol (Berl) 59: 233–236CrossRefGoogle Scholar
  195. Kish S J, Shannak K, Hornykiewicz O (1988) Uneven patterns of dopamin loss in the striatum of patients with idiopathic Parkinsons’ disease. New Engl J Med 318: 876–878PubMedCrossRefGoogle Scholar
  196. Klaue R (1940) Parkinsonsche Krankheit (Paralysis agitans) und postenzephalitischer Parkinsonismus. Versuch einer klinisch-anatomischen Differentialdiagnose. Arch Psychiatr Nervenkr 111: 251–321CrossRefGoogle Scholar
  197. Klawans HL, Lupton M, Simon L (1976) Calcification of the basal ganglia as a cause of levodopa resistant parkinsonism. Neurology (NY) 26: 221–225Google Scholar
  198. Koeppen AH, Barron KD, Cox GL (1971) Striato-nigral degeneration. Acta Neuropathol (Berl) 9: 10–19CrossRefGoogle Scholar
  199. Kosaka K (1978) Lewy bodies in cerebral cortex. Report of three cases. Acta Neuropathol (Berl) 42: 127–134CrossRefGoogle Scholar
  200. Kosaka K, Oyanagi S, Matsushita M, Hori A, Iwase S (1977) Multiple system degeneration involving thalamus, reticular formation, pallido-nigral, pallido-luysian, and dentatorubral system. Acta Neuropathol (Berl) 39: 89–95CrossRefGoogle Scholar
  201. Kosaka K, Matsushita M, Oyanagi S, Uchiyama S, Iwase S (1981) Pallido-nigral-luysial atrophy with massive appearance of corpora amylacea. Acta Neuropathol (Berl) 53: 169–171CrossRefGoogle Scholar
  202. Kosaka K, Yoshimura M, Ikeda K, Budka H (1984) Diffuse type of Lewy body disease. Clin Neuropathol 3: 185–192PubMedGoogle Scholar
  203. Kuzuhara S, Mori H, Izumiyama N, Yoshimura M, Ihara Y (1988) Lewy bodies are ubiquinated. A light and electron microscopic immunocytochemical study. Acta Neuropathol (Berl) 75: 345–353CrossRefGoogle Scholar
  204. Lange HN, Bogerts B (1982) Postencephalitic and idiopathic parkinsonism. Quantitative change of tel-, di-, mesencephalon and basal ganglia (abstr). Neuroscience (Suppl 17 ): 127.Google Scholar
  205. Langston JW, Forno LS (1978) The hypothalamus in Parkinson’s disease. Ann Neurol 3: 129–133PubMedCrossRefGoogle Scholar
  206. Lapresle J, Fardeau M (1967) The central nervous system and carbon monoxide poisoning. II. Anatomical study of brain lesions following intoxication with carbon monoxide (22 cases). Prog Brain Res 24: 31–74PubMedCrossRefGoogle Scholar
  207. Leestma JE, Andrews JM (1969) The fine structure of the Marinesco body. Arch Pathol 88: 431–436PubMedGoogle Scholar
  208. Leverenz J, Sumi SM (1986) Parkinson’s disease in patients with Alzheimer’s disease. Arch Neurol 43: 662–664PubMedCrossRefGoogle Scholar
  209. Lewis PD (1971) Parkinsonism-neuropathology. Br Med J [Clin Res] 3: 690–697CrossRefGoogle Scholar
  210. Lewy FH (1913) Zur pathologischen Anatomie der Paralyse agitans. Dtsch Z Nervenheilk 50: 50–55Google Scholar
  211. Lhermitte J, Kraus WM, McAlpine D (1927) Etude des produits de désintégration et des depots du globus pallidus dans un cas de syndrome parkinsonien. Rev Neurol (Paris) 1: 326–361Google Scholar
  212. Lieberman AM, Dziatolowski M, Kupersmith M, Serby B, Boodgeld A, Korbin J, Goldstein MA (1979) Dementia in Parkinson’s disease. Ann Neurol 6: 355–359PubMedCrossRefGoogle Scholar
  213. Lindenberg R (1964) Die Schädigungsmechanismen der Substantia nigra bei Hirntraumen und das Problem des posttraumatischen Parkinsonismus. Dtsch Z Nervenheilk 185: 637–663CrossRefGoogle Scholar
  214. Llorens-Cortex C, Javoy-Agid F, Agid Y, Taquet H, Schwartz JC (1984) Enkephalinergic markers in substantia nigra and caudate nucleus from parkinsonian subjects. J Neurochem 43: 874–877CrossRefGoogle Scholar
  215. Lockhart MP, Gibson CJ, Ball MJ (1984) Topographical loss of locus coeruleus cells in Alzheimer’s disease. Soc Neurosci Abstr 10: 995Google Scholar
  216. Mann DMA, Yates PO (1983 a) Pathological basis for neurotransmitter changes in Parkinson’s disease. Neuropathol Appl Neurobiol 9: 3–19Google Scholar
  217. Mann DMA, Yates PO (1983 b) Possible role of neuromelanin in the pathogenesis of Parkinson’s disease. Mech Ageing Dev 21: 193–203Google Scholar
  218. Mann DMA, Yates PO, Hawkes J (1983) The pathology of the human locus coeruleus. Clin Neuropathol 2: 1–7PubMedGoogle Scholar
  219. Mann DMA, Yates PO, Marcyniuk B (1984) Changes in nerve cells of the nucleus basalis of Meynert in Alzheimer’s disease and their relationship to aging and to the accumulation of lipofuscin pigment. Mech Ageing Dev 25: 189–204PubMedCrossRefGoogle Scholar
  220. Mann DMA, Yates PO, Marcyniuk B (1985) Correlation between senile plaque and neurofibrillary tangle counts in the cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer’s disease. Neurosci Lett 56: 51–55PubMedCrossRefGoogle Scholar
  221. Mann DMA, Tücken CM, Yates PO (1987 a) The topographic distribution of senile plaques and neurofibrillary tangles in the brains of non-demented persons of different ages. Neuropathol Appl Neurobiol 13: 123–139Google Scholar
  222. Mann DMA, Yates PO, Marcyniuk B (1987 b) Dopaminergic neurotransmitter systems in Alzheimer’s disease and Down’s syndrome at middle age. J Neurol Neurosurg Psychiatry 50: 341–344Google Scholar
  223. Marcyniuk B, Mann DMA, Yates PO (1986) Loss of nerve cells from locus coeruleus in Alzheimer’s disease is topographically arranged. Neurosci Lett 64: 247–252PubMedCrossRefGoogle Scholar
  224. Martin JP (1965) The globus pallidus in post-encephalitic parkinsonism. J Neurol Sci 2: 344–365PubMedCrossRefGoogle Scholar
  225. Martin WRW, Adam MJ, Bergstrom M, Ammann W, Harrop R et al. (1986) In vivo study of DOPA metabolism in parkinson’s disease. In: Fahn S, Marsden CD, Jenner P, Teychenne P (eds) Recent development in Parkinson’s disease. Raven, New York, pp 97–102Google Scholar
  226. Martinez AJ, Utterback RA (1973) Unilateral Parkinson’s disease, clinical and neuropathologic findings. Neurology (Minneap) 23: 164–170Google Scholar
  227. Mata M, Dorovini-Zis K, Wilson M, Young AB (1983) A new form of familial Parkinson-dementia syndrome: clinical and pathologic findings. Neurology (CI) 33: 1439–1443Google Scholar
  228. Matzuk MM, Saper CB (1985) Preservation of hypothalamic dopaminergic neurons in Parkinson’s disease. Ann Neurol 18: 552–555PubMedCrossRefGoogle Scholar
  229. Mayer JM, Mikol J, Haguenau M, Dellanave J, Bepin B (1986) Familial juvenile parkinsonism with multiple systems degenerations. A clinicopathological study. J Neurol Sci 72: 91–101PubMedCrossRefGoogle Scholar
  230. Mayeux R, Stern Y (1983) Intellectual dysfunction and dementia in Parkinson disease. In: Mayeux R, Rosen WG (eds): The dementias. Raven New YorkGoogle Scholar
  231. Mayeux R, Stern V, Cote L, Williams JBW (1984) Altered serotonin metabolism in depressed patients with Parkinson’s disease. Neurology (CI) 34: 642–646Google Scholar
  232. Mayeux R, Stern Y, Rosenstein Y et al. (1988) An estimate of the prevalence of dementia in idiopathic Parkinson’s disease. Arch Neurol 45: 260–262PubMedCrossRefGoogle Scholar
  233. McGeer PI, McGeer EG (1976) Enzymes associated with the metabolism of catecholamines, acetylcholine and GABA in human controls and patients with Parkinson’s disease and Huntington’s chorea. J Neurochem 26: 65–76PubMedGoogle Scholar
  234. McGeer PL, McGeer EG, Suzuki J (1984) Aging, Alzheimer’s disease, and the cholinergic system of the basal forebrain. Neurology (CI) 34: 741–745Google Scholar
  235. McGeer PL, Itagaki S, Boyes BE, McGeer EG (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson’s and Alzheimer’s disease brains. Neurology 38: 1285–1291PubMedGoogle Scholar
  236. Mesulam MM, Mufson EJ (1984) Neuronal inputs into the nucleus basalis of the substantia innominata (Ch 4) in the rhesus monkey. Brain 107: 253–274PubMedCrossRefGoogle Scholar
  237. Miller C, Haugh M, Kahn J, Anderson B (1986) The cytoskeleton and neurofibrillary tangles in Alzheimer’s disease. Trends Neurosci 9: 76–81CrossRefGoogle Scholar
  238. Mizusawa H, Yen SH, Hirano A (1989) Grumose degeneration of the dentate nucleus in progressive supranuclear palsy Acta Neuropathol 77 (in press)Google Scholar
  239. Mizutani T, Oda M, Abe H, Fukuda S, Oikawa H, Kosaka K (1983) Hereditary multi-systemic degeneration with unusual combination of cerebellopetal, dentato-rubral, and nigro-subthalamo-pallidal degeneration. Clin Neuropathol 2: 147–153PubMedGoogle Scholar
  240. Molsa PK, Martilla RJ, Rinne UK (1984) Extrapyramidal signs in Alzheimer’s disease. Neurology (CI) 34: 1114–1116Google Scholar
  241. Mori H, Yoshimura M, Tomonaga H, Yamanouchi H (1986) Progressive supranuclear palsy with Lewy bodies. Acta Neuropathol (Berl) 71: 344–346CrossRefGoogle Scholar
  242. Mori H, Kondo J, Ihara Y (1987) Ubiquitin is a component of paired helical filaments in Alzheimer’s disease. Science 235: 1641–1644PubMedCrossRefGoogle Scholar
  243. Morimura Y, Hirano Y, Llena JF (1985) Electron microscopic observations of the nucleus basalis Meynert in human autopsy cases. Acta Neuropathol (Berl) 68: 130–137CrossRefGoogle Scholar
  244. Morris JC, Drazner M, Fulling K, Berg L (1987) Parkinsonism in senile dementia of the Alzheimer type. In: Wurtman RJ, Corkin SJ, Growden JH (eds) Alzheimer’s disease: advances in basic research and therapies. Center for Brain Science and Metabolism Charitable Trust, Cambridge, pp 499–504Google Scholar
  245. Morrison JH, Scherr S, Lewis DA, Campbell MJ, Bloom FE (1986) The laminar and regional distribution of somatostatin and neuritic disconnection syndrome. In Scheibel AB, Wechsler AF (eds) The biological substrates of Alzheimer’s disease. Academic, Orlando, pp 115–131Google Scholar
  246. Mortimer JA, Pirozzlo FF, Hansch EC, Webster DD (1982) Relationship of motor symptoms to intellectual deficits in Parkinson’s disease. Neurology (NY) 32: 133–137Google Scholar
  247. Mouchet P, Manier M, Dietl M, Feuerstein C, Berod A, Arluison A, Denorys L, Thibaut J (1986) Immunohistochemical study of catecholaminergic cell bodies in the rat spinal cord. Brain Res Bull 16: 341–353PubMedCrossRefGoogle Scholar
  248. Mountjoy CA, Rossor MN, Iversew LI, Roth M (1984): Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia. Brain 107: 507–518PubMedCrossRefGoogle Scholar
  249. Nagatsu T, Oka K, Yamamoto T, Matusui H et al. (1981) Catecholaminergic enzymes in Parkinson’s disease and related extrapyramidal diseases. In: Riederer P, Usdin E (eds) Transmitter biochemistry of human tissue. Macmillan, London, pp 291–302Google Scholar
  250. Nakano I, Hirano A (1983) Neuron loss in the nucleus basalis of Meynert in Parkinson-dementia complex of Guam. Ann Neurol 13: 87–91PubMedCrossRefGoogle Scholar
  251. Nakano I, Hirano A (1984) Parkinson’s disease: neuron loss in the nucleus basalis without concomitant Alzheimer’s disease. Ann Neurol 15: 415–418PubMedCrossRefGoogle Scholar
  252. Nakashima S, Ikuta F (1984 a) Catecholamine neurons with Alzheimer’s neurofibrillary changes and alteration of tyrosine hydroxylase: immunohistochemical investigation of tyrosine hydroxylase. Acta Neuropathol (Berl) 64: 273–280Google Scholar
  253. Nakashima S, Ikuta F (1984 b) Tyrosin hydroxylase proteins in Lewy bodies of parkinsonism and senile brain. J Neurol Sci 66: 91–96Google Scholar
  254. Nakashima S, Kumanishi T, Ikuta F (1983) Immunohistochemistry on tyrosine hydroxylase in the substantia nigra of human autopsied cases. Brain Nerve 35: 1023–1029PubMedGoogle Scholar
  255. Nakazato X, Sasaki A, Hirato J, Ishida Y (1984) Immunohistochemical localization of neurofilament protein in neuronal degenerations. Acta Neuropathol (Berl) 64: 30–36CrossRefGoogle Scholar
  256. Narabayashi H, Yokochi M, Iizuka R, Nagatsu T (1986) Juvenile parkinsonism. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of clinical neurology, vol 49. Elsevier Scientific, Amsterdam New York, pp 153–165Google Scholar
  257. Neary D, Snoweden JS, Mann DMA et al. (1986) Alzheimer’s disease; a correlative study. J Neurol Neurosurg Psychiatry 49: 129–137Google Scholar
  258. Nieuwenhuys R (1985) Chemoarchitecture of the brain. Springer, Berlin Heidelberg New York, TokyoGoogle Scholar
  259. Ohama E, Ikuta F (1976) Parkinson’s disease. Distribution of Lewy bodies and mono-amine neuron system. Acta Neuropathol (Berl) 34: 311–319CrossRefGoogle Scholar
  260. Olszewski J, Baxter D (1982) Cytoarchitecture of the human brain stem, 2nd edn. Karger, Basle New YorkGoogle Scholar
  261. Oppenheimer N (1984) Diseases of the basal ganglia, cerebellum and motor neurons. In: Adams JH, Corsellis JAN, Duchen LW (eds) Greenfield’s neuropathology, 4th ed. Arnold, London, pp 698–747Google Scholar
  262. Oyanagi K, Nakashima S, Ikuta F, Honma Y (1986) An autopsy case of dementia and parkinsonism with severe degeneration exclusively in the substantia nigra. Acta Neuropathol (Berl) 71:Google Scholar
  263. Pakkenberg H, Brody H (1965) The number of nerve cells in the substantia nigra in paralysis agitans. Acta Neuropathol (Berl) 5: 320–324CrossRefGoogle Scholar
  264. Palmer AM, Procter AW, Stratman GC, Bowen DM (1986) Excitatory amino acidreleasing and cholinergic neurones in Alzheimer’s disease. Neurosci Lett 66: 199–204PubMedCrossRefGoogle Scholar
  265. Pappola MA (1986) Lewy bodies of Parkinson’s disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments. Arch Pathol Lab Med 110: 1160–1163Google Scholar
  266. Parkes JSD, Marsden CD, Rees JE (1974) Parkinson’s disease, cerebral arteriosclerosis and senile dementia: clinical features and response to levodopa. J Med 4: 93: 49–61Google Scholar
  267. Parkinson J (1817) An essay on the shaking palsy. Willingham and Rowland LondonGoogle Scholar
  268. Parnitzke KH, Peiffer J (1956) Zur Klinik der pathologischen Anatomie der chronischen Braunsteinvergiftung. Arch Psychiat Nervenkr 192: 405–427CrossRefGoogle Scholar
  269. Pearce GW (1979) The neuropathology of parkinsonism. In: Smith WT, Canavagh JB (eds) Recent advances in neuropathology, vol I. Churchill-Livingstone, London, pp 299–320Google Scholar
  270. Pearce J (1974) The extrapyramidal disorder of Alzheimer’s disease. Eur Neurol 12: 94–103PubMedCrossRefGoogle Scholar
  271. Pearson J (1983) Neurotransmitter immunocytochemistry in the study of human development, anatomy and pathology. Prog Neuropathol 5: 41–97Google Scholar
  272. Pearson RCA, Esiri MM, Hiorns RW, Woldock GK, Powell TPS (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer’s disease. Proc Natl Acad Sci USA 82: 4531–4534PubMedCrossRefGoogle Scholar
  273. Pearson RCA, Powell TPS (1987) Anterograde vs retrograde degeneration of the nucleus basilis medialis in Alzheimer’s disease. J Neurol Transm Suppl 24: 139–146Google Scholar
  274. Pearson RCA, Sofroniew MV, Cuello AC et al. (1983) Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer’s type demonstrated by immunohistochemical staining for choline acetyltransferase. Brain Res 289: 375–379PubMedCrossRefGoogle Scholar
  275. Pearson RCA, Esiri MM, Hions RW, Waldeck GK, Powell TPS (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer’s disease. Proc Natl Acad Sci USA 82: 4531–4534PubMedCrossRefGoogle Scholar
  276. Pendlebury WV, Perl DL (1984) Nucleus basalis of Meynert: severe cell loss in Parkinson’s disease without dementia (abstr). Ann Neurol 16: 124Google Scholar
  277. Perl DP, Pendlebury WV, Bird FD (1984) Detailed neuropathologic evaluation of banked brain specimens submitted with a clinical diagnosis of Alzheimer’s disease. In: Wurtman RJ, Corkin SH, Growden JH (eds) Proc, 3rd meeting of the Int study group on the treatment of memory disorders associated with aging, p 463Google Scholar
  278. Perry EK, Curtis M, Dick DJ, Candy JM, Atack JH, Bloxham CA, Blessed G, Fairburn A, Tomlinson BE, Perry RH (1985) Cholinergic correlates of cognitive impairment in Parkinson’s disease: comparison with Alzheimer’s disease. J Neurol Neurosurg Psychiatry 48: 413–421PubMedCrossRefGoogle Scholar
  279. Perry EK, Perry RH, Smith CJ, Dick DJ, Candy JM, Edwardson JA, Fairbairn A, Blessed JG (1987) Nicotinic receptor abnormalities in Alzheimer’s and Parkinson’s diseases. J Neurol Neurosurg Psychiatry 50: 806–809PubMedCrossRefGoogle Scholar
  280. Perry G, Manetto V, Autilio-Gambetti L, Gambetti P (1987 a) Straight filaments of Alzheimer neurofibrillary tangles (abstr). J Neuropathol Exp Neurol 46: 334Google Scholar
  281. Perry G, Friedman R, Shaw G, Chau V (1987b) Ubiquitinis detected in neurofibrillary tanges and senile plaque neurites of Alzheimer disease brains. Proc Natl Acad Sci USA 84: 3033–3036PubMedCrossRefGoogle Scholar
  282. Perry RH, Candy H, Perry EK, Irving D, Blessed C et al. (1983 a) Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus basalis of Meynert in Alzheimer’s disease. Neurosci Lett 33: 311–315Google Scholar
  283. Perry RH, Tomlinson BE, Candy JM, Blessed G et al. (1983 b) Cortical cholinergic deficit in mentally impaired Parkinsonian patients. Lancet 2: 789–790Google Scholar
  284. Perry RH, Perry EK, Smith CJ, Xuereb JH, Irving D, Whitford CA, Candy JM, Cross AJ (1987) Cortical neuropathological and neurochemical substrates of Alzheimer’s and Parkinson’s disease. J Neurol Transm [Suppl] 24: 131–136Google Scholar
  285. Perry TL, Bratty PLA, Hansen S et al. (1975) Hereditary mental depression and parkinsonism with taurine deficiency. Arch Neurol 32: 108–113PubMedCrossRefGoogle Scholar
  286. Peterson C, Kress V, Vallee R, Goldman JE (1988) High molecular weight microtubule-associated proteins bind to actin lattices (Hirano bodies). Acta Neuropathol (Berl) 77Google Scholar
  287. Poewe W, Gerstenbrand F (1986) Klinische Klassifikation des Parkinson-Syndroms: Subtypen und Übergänge zu Multi-System-Atrophien. In: Schnaberth G, Auff E (eds) Das Parkinson-Syndrom. Roche, Vienna; pp 39–46Google Scholar
  288. Popovitch ER, Wisniewski HM, Kaufman MA, Grundke-Iqbal I, Yen GY (1987) Young adult form of dementia with neurofibrillary changes and Lewy bodies. Acta Neuropathol (Berl) 47–104Google Scholar
  289. Price DL, Whitehouse PJ, Struble RG et al. (1983) Basal forebrain cholinergic neurons and neuritic plaques in primate brains. In: Katzman R (ed) Biological aspects of Alzheimer’s Disease. Cold Spring Harbor, Banbury report, vol 15. New York, pp 65–77Google Scholar
  290. Price DL, Whitehouse PJ, Struble RG (1986) Cellular pathology in Alzheimer’s and Parkinson’s disease. Trends Neurosci 9: 29–33CrossRefGoogle Scholar
  291. Purdy A, Hahn A, Barnett HJM, Bratty P (1979) Familial fatal parkinsonism with alveolar hypoventilation and mental depression. Ann Neurol 6: 523–531PubMedCrossRefGoogle Scholar
  292. Quinn NP, Rossor MN, Marsden CD (1986) Dementia and Parkinson’s disease. Pathological and neurochemical considerations. Br Med Bull 42: 86–96PubMedGoogle Scholar
  293. Rail D, Scholtz C, Swash M (1981) Post-encephalitic parkinsonism: current experience. J Neurol Neurosurg Psychiatry 44: 670–676PubMedCrossRefGoogle Scholar
  294. Rajput AH, Rozdilsky B, Hornykiewicz O, Shannak K et al. (1982) Reversible drug-induced Parkinsonism. Clinicopathologic study of two cases. Arch Neurol 39: 644–646PubMedCrossRefGoogle Scholar
  295. Rasooft CS, Selkoe DJ (1985) Recognition of Pick bodies by antibodies to neurofibrillary tangles in Alzheimer’s disease. N Engl J Med 310: 700–705Google Scholar
  296. Rasool CS, Svendsen CN, Selkoe DJ (1986) Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer’s disease. Ann Neurol 20: 482–488PubMedCrossRefGoogle Scholar
  297. Richardson EP (1965) Remarks on the pathology of Parkinson’s disease. In: Barbeau A, Doshay LJ, Spiegel EA (eds) Parkinson’s disease: trends in research and treatment. Grune and Stratton, New York, pp 63–68Google Scholar
  298. Richardson EP (1986) Editorial. Parkinson’s disease. Ann Neurol 20: 447–448PubMedCrossRefGoogle Scholar
  299. Riederer P, Wuketich S (1976) Time course of striatonigral degeneration in Parkinson’s disease. J Neural Transm 38: 277–301PubMedCrossRefGoogle Scholar
  300. Riederer P, Birkmayer W, Seeman D, Wuketich S (1977) Brain noradrenalin and 3-methoxy-4-hydroxy-phenylglycol in Parkinson’s syndrome. J Neural Transm 41: 241–251PubMedCrossRefGoogle Scholar
  301. Riederer P, Sofie E, Rausch WD, Kruzik P, Youdim MBH (1985) Dopaminforschung heute und morgen—L-Dopa in der Zukunft. In: Riederer P, Umek H (eds) L-Dopa-Substitution der Parkinson-Krankheit. Geschichte — Gegenwart — Zukunft. Springer, Vienna New York, pp 127–144Google Scholar
  302. Riederer P, Rausch WD, Schmidt B et al. (1988) Biochemical fundamentals of Parkinson’s disease. Mount Sinai J Med 55: 21–28Google Scholar
  303. Rogers JD, Brogan D, Mirra SS (1985) The nucleus basalis of Meynert in neurological disease: a quantitative morphological study. Ann Neurol 17: 163–170PubMedCrossRefGoogle Scholar
  304. Rojas G, Asenhjo A, Chiorino R, Aranda L, Rocamora R, Donosa P (1965) Cellular and subcellular structure of the ventrolateral nucleus of thalamus in Parkinson’s disease: deposits of iron. Confin Neurol 26: 362–376PubMedGoogle Scholar
  305. Rosenberg N (1984) Joseph disease, an autosomal motor system degeneration. Adv Neurol 41: 179–194PubMedGoogle Scholar
  306. Rosenblum WI, Ghatak NR (1979) Lewy bodies in the presence of Alzheimer’s disease. Arch Neurol 36: 170–171PubMedCrossRefGoogle Scholar
  307. Rossor MN, Svedsen C, Hunt SP, Mountjoy CG, Roth M, Iversen LL (1984) The substantia innominata in Alzheimer’s disease: a histochemical and biochemical study of cholinergic marker enzymes. Neurosci Lett 28: 217–222CrossRefGoogle Scholar
  308. Roy S, Wolman L (1969) Ultrastructural observations in parkinsonism. J Pathol 99: 39–44PubMedCrossRefGoogle Scholar
  309. Rudelli RD, Ambler MW, Wisniewski HM (1984) The morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon. Acta Neuropathol (Berl) 64: 273–281CrossRefGoogle Scholar
  310. Rutledge JN, Hilal SK, Silver AJ, Defendini R, Fahn S (1987) Study of movement disorders and brain iron by MR. Am J Roentgenol 149: 365–379Google Scholar
  311. Sabuncu N (1969) Quantitative Untersuchungen am Pallidum beim Parkinsonsyndrom. Dtsch Z Nervenheilk 196: 40–48Google Scholar
  312. Saper CB, German DC, White CL (1985) Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer’s type. Possible role in cell loss. Neurology (NY) 35: 1089–1095Google Scholar
  313. Scarnati E, Gasbarri A, Campana E, Pacitti C (1987) The organization of nucleus tegmenti pedunculopontine neurons projecting to basal ganglia and thalamus. Neurosci Lett 79: 11–16PubMedCrossRefGoogle Scholar
  314. Scatton B, Dennis T, Lheureux R, Montofort J, Duyckaerts C, Javoy K, Agid F (1986) Degeneration of noradrenergic and serotonergic but not dopaminergic neurons in the lumbar spinal cord of parkinsonian patients. Brain Res 380: 181–185PubMedCrossRefGoogle Scholar
  315. Schmitt HP, Emser W, Heimes C (1984) Familial occurrence of amyotrophic lateral sclerosis, parkinsonism and dementia. Ann Neurol 16: 642–648PubMedCrossRefGoogle Scholar
  316. Schneider E, Becker H, Fischer PA et al. (1979) The course of brain atrophy in Parkinson’s disease. Arch Psychiat Nervenkrankh 227: 89–95CrossRefGoogle Scholar
  317. Schochet SS, Wyatt S, McCormick WF (1970) Intracytoplasmic acidophiliac granules in the substantia nigra. Arch Neurol 22: 550–555PubMedCrossRefGoogle Scholar
  318. Schoene WC (1985) Diseases of the mesencephalon involving the substantia nigra and related systems of neurons. In: Davis RL, Robertson DH (eds) Textbook of neuropathology. Williams and Wilkins, Baltimore, pp 798–804Google Scholar
  319. Schwab R, England AD (1968) Parkinson syndromes due to various specific causes. In: Vinken P, Bruyn GW (eds) Handbook of clinical neurology, vol 6. North-Holland, Amsterdam, pp 227–247Google Scholar
  320. Scitelberger F (1986) Neuroaxonal dystrophy: its relation to aging and neurological diseases. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of clinical neurology, vol 5 ( 49 ) Elsevier Scientific, Amsterdam, New York: pp 391–415Google Scholar
  321. Sima AAF, Clark AW, Sternberger NA, Sternberger LA (1986) Lewy body dementia without Alzheimer changes. Can J Neurol Sci 13: 490–497PubMedGoogle Scholar
  322. Simchowicz T (1911) Histologische Studien über die senile Demenz. Histol Histopath Arb 4: 267–444Google Scholar
  323. Sparks DL, Markesberry WR, Slevin JT (1986) Alzheimer’s disease: monoamines and spiperone binding reduced in nucleus basalis. Ann Neurol 19: 602–604Google Scholar
  324. Spencer PS, Nunn PB, Hugon JS (1986) Motoneuron disease of Guam: possible role of a food neurotoxin. Lancet 1: 965PubMedCrossRefGoogle Scholar
  325. Sroka H, Elizan TS, Yahr MD, Binger A, Mendazu MR (1981) Organic mental syndrome and confusional states in Parkinson’s disease. Arch Neurol 38: 339–342PubMedCrossRefGoogle Scholar
  326. Stadlan EM, Duvoisin R, Yahr MD (1966) The pathology of parkinsonism. Proc, 5th Int Congr Neuropathol, ICS 100. Excerpta Medica, Amsterdam, pp 569–571Google Scholar
  327. Steele JC, Richardson JC, Olszewski J (1964) Progressive supranuclear palsy. Arch Neurol 10: 333–359PubMedCrossRefGoogle Scholar
  328. Stockhausen P, Braak H (1984) Morphological changes of the isocortex in morbus Parkinson. Clin Neuropathol 3: 206–209PubMedGoogle Scholar
  329. Struble RG, Cork LC, Whitehouse PJ et al. (1982) Cholinergic innervation in neuritic plaques. Science 216: 413–415PubMedCrossRefGoogle Scholar
  330. Struble RG, Powers RE, Casanova MF, Kitt CA, O’Connor DT, Price DL (1985) Multiple transmitter-specific markers in senile plaque in Alzheimer’s disease (abstr). J Neuropathol Exp Neurol 44: 325CrossRefGoogle Scholar
  331. Sudhaker S, Rajput AH, Rozdilsky B, Uitti RJ (1987) A clinicopathologic study of neurofibrillary tangles in Parkinsonism. Neurology 37 (Suppl l): 278–279Google Scholar
  332. Sugimura K, Yamasaki Y, Ando K (1977) Parkinson’s disease accompanied by dementia. A case of concurrent Parkinson’s and Alzheimer’s diseases. Rinsho Shin Keigaku 12: 513–519Google Scholar
  333. Sulkova R, Haltia M, Paltau A et al. (1983) Accuracy of clinical diagnosis in primary degenerative dementia. Correlation with neuropathological findings. J Neurol Neurosurg Psychiatry 46: 9–13CrossRefGoogle Scholar
  334. Taban CH, Bouras C, Constantinidis J (1984) Substance P like immunoreactivity in the substantia nigra in one case of Huntington’s chorea and in one case of Parkinson’s disease compared to normal brain. In: Tagliavini LF, Pilleri G (eds) Brain pathology, vol 1. pp 219–228Google Scholar
  335. Tabaton M, Schenone A, Romagnoli P, Mancardi GL (1985) A quantitative and ultra-structural study of substantia nigra and nucleus centralis superior in Alzheimer’s disease. Acta Neuropathol (Berl) 68: 218–223CrossRefGoogle Scholar
  336. Tagliavini F, Pilleri G (1983) Basal nucleus of Meynert. A neuropathological study in Alzheimer’s disease, simple senile dementia, Pick’s disease and Huntington’s chorea. J Neurol Sci 62: 243–260PubMedCrossRefGoogle Scholar
  337. Tagliavini F, Pilleri G (1984) The basal nucleus of Meynert in cerebral aging and degenerative dementias. In: Tagliavini F, Pilleri G (eds) Brain pathology, vol 1. Bern pp 181–218Google Scholar
  338. Tagliavini F, Pilleri G, Bouras C, Constantinidis J (1984a) The nucleus basal of Meynert in idiopathic Parkinson’s disease. Acta Neurol Scand 69: 20–28CrossRefGoogle Scholar
  339. Tagliavini F, Pilleri G, Bouras C, Constantinidis J (1984b) The basal nucleus of Meynert in patients with progressive supranuclear palsy. Neurosci Lett 44: 37–42PubMedCrossRefGoogle Scholar
  340. Takahashi K, Nakashima R, Takao T, Nakamura H (1977) Pallido-nigro-luysian atrophy associated with degeneration of the centrum medianum. Acta Neuropathol (Berl) 37: 81–85CrossRefGoogle Scholar
  341. Takauchi S, Mizumara T, Miyoshi K (1983) Unusual paired helical filaments in progressive supranuclear palsy. Acta Neuropathol (Berl) 59: 225–228CrossRefGoogle Scholar
  342. Takeda S, Ohama E, Izumo S et al. (1982) Substantia nigra and locus coeruleus in Parkinson-dementia cemplex of Guam and OPCA. In: Sciteiberger F, Lassmann H, Jellinger K (eds) Abstracts of the IXth int congr neuropathol, Vienna, Wiener Medizinische Akademie, pp 115Google Scholar
  343. Takei Y, Mirra SS (1973) Striatonigral degeneration, a form of multisystem atrophy with clinical parkinsonism. Prog Neuropathol 2: 217–251Google Scholar
  344. Tellez-Nagel I, Wisniewski HM (1973) Ultrastructure of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome. Arch Neurol 29: 324–327PubMedCrossRefGoogle Scholar
  345. Tenovuo O, Rinne UK, Viljanen MK (1984) Substance P immunoreactivity in the post-mortem Parkinsonian brain. Brain Res 303: 113–116PubMedCrossRefGoogle Scholar
  346. Terry RD (1985) Alzheimer’s disease. In: Davis RD, Robertson DM (eds) Textbook of 110 neuropathology. Williams and Wilkins, Baltimore, pp 824–841Google Scholar
  347. Tohgi H (1977) Arteriosclerotic parkinsonism: a reassessment. 11th world congr neurol, ICS 427 Excerpta Medica, Amsterdam, p 200Google Scholar
  348. Tolosa ES, Santamaria J (1984) Parkinsonism and basal ganglia infarcts. Neurology (CI) 34: 1516–1518Google Scholar
  349. Tomlinson BE, Corsellis JAN (1984) Ageing and the dementias. In: Adams JH, Corsellis JAN, Duchen LW (eds) Greenfield’s neuropathology, 4th edn. Arnold, London, pp 951–1025Google Scholar
  350. Tomlinson BE, Irving D, Blessed G (1981) Cell loss in the locus coeruleus in senile dementia of the Alzheimer type. J Neurol Sci 49: 419–428PubMedCrossRefGoogle Scholar
  351. Tomonaga M (1981) Neurofibrillary tangles and Lewy bodies in the locus coeruleus neurons of the aged brain. Acta Neuropathol (Berl) 53: 165–168CrossRefGoogle Scholar
  352. Tomonaga M (1983) Neuropathology of the locus coeruleus: a semiquantitative study. J Neurol 230: 231–240PubMedCrossRefGoogle Scholar
  353. Torack RM, Morris JC (1988) The association of ventral tegmental area histopathology with adult dementia. Arch Neurol 45: 497–501PubMedCrossRefGoogle Scholar
  354. Trétiakoff C (1919) Contribution à l’étude de l’anatomie pathologique du locus niger. Thesis, University of ParisGoogle Scholar
  355. Uhl GR, McKinney M, Hedreen JC, White CL, Coyle JT, Whitehouse PJ, Price DL (1982) Dementia pugilistica: loss of basal forebrain cholinergic neurons and cortical cholinergic markers. Ann Neurol 12: 99Google Scholar
  356. Uhl GR, Hedreen JC, Price DL (1985) Parkinson’s disease: loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesions. Neurology 35: 1215–1218PubMedGoogle Scholar
  357. Uhl GR, Hackney GO, Torchia M, Stranov V, Tourtellotte WW, Whitehouse PJ, Vinh Tran, Strittmacher S (1986) Parkinson’s disease. Nigral receptor changes support peptidergic role in nigrostriatal modulation. Ann Neurol 20: 194–203PubMedCrossRefGoogle Scholar
  358. Uitti RJ, Rajput AH, Ashenhust EM, Rozdilsky B (1985) Cyanide-induced parkinsonism: a clinico pathologic study. Neurology (NY) 35: 921–925Google Scholar
  359. Van Bogaert L (1956) Sur le parkinsonism saturnien avec paralysie de movements oculaires associées. Etude anatomique. Mschr Psychiatr Neurol 131: 73–88CrossRefGoogle Scholar
  360. Wakabayashi K, Takahashi H, Takeda S et al. (1988) Parkinson’s disease: the presence of Lewy bodies in Auerbach’s and Meissner’s plexuses. Acta Neuropathol (Berl.) 76: 217–221CrossRefGoogle Scholar
  361. Whitehouse PJ (1986) The concept of subcortical and cortical dementia: another look. Ann Neurol 19: 1–6PubMedCrossRefGoogle Scholar
  362. Whitehouse PJ, Hendreen JC, White CL, Price DL (1983) Basal forebrain neurons in the dementia of Parkinson’s disease. Ann Neurol 13: 243–248PubMedCrossRefGoogle Scholar
  363. Wilcock GK, Esiri MM (1982) Plaques and dementia: a quantitative study. J Neurol Sci 56: 343–356PubMedCrossRefGoogle Scholar
  364. Wilkening G, Vernier VG, Arthaud LE, Treacy G, Kenney JP, Nickolson VJ, Clark R, Smith DH, Boswell G (1986) A parkinson-like neurologic deficit in primates is caused by a novel 4-substituted piperidine. Brain Res 368: 239–246PubMedCrossRefGoogle Scholar
  365. Willis GL (1987) Amine accumulation in Parkinson’s disease and other disorders. Neurosci Biobehavior Rev 11: 97–105CrossRefGoogle Scholar
  366. Wisniewski HM, Merz GS (1985) Neuropathology of the aging brain and dementia of Alzheimer type. In: Haitz CH, Samorajski T (eds) Aging 2000; our health care destiny, Vol 1. Biomedical issue. Springer, Berlin Heidelberg New York, pp 231–243Google Scholar
  367. Wisniewski HM, Wen GY (1985) Substructures of paired helical filaments from Alzheimer neurofibrillary tangles. Acta Neuropathol (Berl) 66: 173–176CrossRefGoogle Scholar
  368. Wisniewski HM, Terry RD, Hirano A (1970) Neurofibrillary pathology. J Neuropathol Exp Neurol 29: 163–176PubMedCrossRefGoogle Scholar
  369. Wisniewski K, Jervis GA, Moretz RC, Wisniewski HM (1979) Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia. Ann Neurol 5: 288–294PubMedCrossRefGoogle Scholar
  370. Wisniewski K, Wisniewski HM, Wen GY (1985) Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome. Ann Neurol 17: 278–282PubMedCrossRefGoogle Scholar
  371. Wuketich ST, Riederer P, Jellinger K, Ambrozi L (1980) Quantitative dissection of human brain areas. J Neural Transm [Suppl] 16: 53–67Google Scholar
  372. Xuereb JHM, Perry RH, Irving D (1987) The dementia in Parkinson’s disease (abstr). Neuropathol Appl Neurobiol 13: 231.Google Scholar
  373. Yagishita S, Itoh Y, Amano N, Nakano T (1979) Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy. Acta Neuropathol (Berl) 48: 27–30CrossRefGoogle Scholar
  374. Yagishita S, Oto Y, Wang N, Amano N (1981) Reapprasial of the fine structure of Alzheimer’s neurofibrillary tangles. Acta Neuropathol (Berl) 54: 239–245CrossRefGoogle Scholar
  375. Yahr MD, Wolf A, Antunes JL, Miyoshi K, Duffy P (1972) Autopsy findings in parkinsonism following treatment with levodopa. Neurology (Minneap) 22 (Suppl II): 56–65Google Scholar
  376. Yamada M, Mehraein P (1977) Verteilungsmuster der senilen Veränderungen in den Hirnstammkernen. Folia Psychiatr Neurol Jpn 31: 219PubMedGoogle Scholar
  377. Yamada M, Ohno S, Okayasu I, Okeda R, Hatakeyama S, Watanabe H, Ushio K, Tsukagoshi H (1986) Chronic manganese poisoning: a neuropathological study with determination of manganese distribution. Acta Neuropathol (Berl) 70: 273–277CrossRefGoogle Scholar
  378. Yamamoto T, Hirano A (1985 a) Nucleus raphe dorsalis in Alzheimer’s disease; neurofibrillary tangles and loss of neurons. Ann Neurol 17: 573–577Google Scholar
  379. Yamamoto T, Hirano A (1985 b) Nucleus raphe dorsalis in Parkinson’s dementia complex of Guam. Acta Neuropathol (Berl) 67: 296–299Google Scholar
  380. Yen SH, Horoupian DS, Terry RD (1983) Immunocytochemical comparison of neurofibrillary palsy, and postencephalitic parkinsonism. Ann Neurol 13: 172–175PubMedCrossRefGoogle Scholar
  381. Yen SH, Dickson DW, Peterson C, Goldman JE (1986) Cytoskeletal abnormalities in neuropathology. Prog Neuropathol 6: 63–90Google Scholar
  382. Yokochi M, Narabayashi H, Ilzuka R, Nagatsu T (1984) Juvenile parkinsonism—some clinical, pharmacological and neuropathological aspects. Adv Neurol 40: 407–413PubMedGoogle Scholar
  383. Yoshimura M (1983) Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”. J Neurol 229: 17–32PubMedCrossRefGoogle Scholar
  384. Yoshimura N, Yoshimura I, Kudo H, Asada M, Hayashi S, Fukushima Y, Sato T (1989) Juvenile Parkinson’s disease with widespread Lewy bodies in the cerebral cortex. Acta Neuropathol (Berl) 77:Google Scholar
  385. Younkin SG, Goodridge B, Lockett G, Usiak M, Younkin LH (1986) Morphometry of cholinergic neurons in Alzheimer’s disease (abstr). J Neuropathol Exp Neurol 45: 341CrossRefGoogle Scholar
  386. Yuen P, Baxter DW (1963) The morphology of Marinesco bodies (paranucleolar corpuscles) in the melanin-pigmented nuclei of the brain stem. J Neurol Neurosurg Psychiatry 26: 178–183PubMedCrossRefGoogle Scholar
  387. Zech M, Bogerts B (1985) Methionine, enkephalin and substance P in the basal ganglia of schizophrenics; a quantitative immunohistochemical comparison with Huntington and Parkinson patients. Acta Neuropathol (Berl) 68: 32–38CrossRefGoogle Scholar
  388. Zetusky WJ, Jankovic J, Pirozzolo FJ (1985) The heterogeneity of Parkinson disease: clinical and prognostic implications. Neurology (NY) 35: 522–526Google Scholar
  389. Zweig RM, Whitehouse PJ, Casanova MF, Walker LC, Jankel WR, Pride CL (1987) Loss of pedunculopontine neurons in progressive supranuclear palsy. Ann Neurol 22: 18–25PubMedCrossRefGoogle Scholar
  390. Zweig RM, Rose CA, Hedren IC et al. (1988) The neuropathology of aminergic nuclei in Alzheimer’s disease. Ann Neurol 24: 233–242PubMedCrossRefGoogle Scholar

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  • K. Jellinger

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